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Net Loss Per Ordinary Share - Calculation of Basic and Diluted Net Loss Per Share (Detail) - USD ($)
$ / shares in Units, shares in Thousands, $ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Numerator:        
Net loss $ (59,882) $ (17,701) $ (108,625) $ (53,085)
Denominator        
Weighted-average ordinary shares outstanding (in shares) 39,824 38,073 39,257 36,922
Net loss per share        
Basic and diluted net loss per share (in dollars per share) $ (1.50) $ (0.46) $ (2.77) $ (1.44)