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Net Loss Per Ordinary Share - Ordinary Shares Equivalent Not Included in Diluted Net Loss Per Share (Detail) - shares
shares in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Options to purchase ordinary shares [Member]        
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]        
Stock options to purchase ordinary shares not included in diluted net loss per share 4,608 4,121 4,608 4,121