Organization - Additional Information (Detail) (USD $)
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1 Months Ended | 2 Months Ended | |||||
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Sep. 30, 2014
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Dec. 31, 2013
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Sep. 30, 2013
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Dec. 31, 2012
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Feb. 28, 2014
License
Roche
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May 31, 2014
Collaborative Arrangement
Roche
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Jul. 31, 2014
Underwritten Public And Over-Allotment Offering
Ordinary Shares
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Organization [Line Items] | |||||||
Accumulated deficit | $ 35,381,000 | $ 41,341,000 | |||||
Cash and cash equivalents | 306,153,000 | 176,677,000 | 101,859,000 | 124,860,000 | |||
Upfront payment pursuant to License Agreement | 30,000,000 | ||||||
Clinical milestone received | 15,000,000 | ||||||
Shares sold pursuant to underwritten public offering (in shares) | 5,462,500 | ||||||
Net proceeds from issuance of ordinary shares in underwritten public offering | $ 117,400,000 |