As filed with the Securities and Exchange Commission on March 2, 2023
Registration No. 333-
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
SYROS PHARMACEUTICALS, INC.
(Exact Name of Registrant as Specified in Its Charter)
Delaware | 45-3772460 | |
(State or Other Jurisdiction of Incorporation or Organization) |
(I.R.S. Employer Identification No.) | |
35 CambridgePark Drive, 4th Floor Cambridge, Massachusetts |
02140 | |
(Address of Principal Executive Offices) | (Zip Code) |
2016 Employee Stock Purchase Plan
2022 Inducement Stock Incentive Plan
(Full Title of the Plan)
Nancy Simonian, M.D.
President and Chief Executive Officer
Syros Pharmaceuticals, Inc.
35 CambridgePark Drive, 4th Floor
Cambridge, Massachusetts
(Name and Address of Agent for Service)
(617) 744-1340
(Telephone Number, Including Area Code, of Agent for Service)
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of large accelerated filer, accelerated filer, smaller reporting company, and emerging growth company in Rule 12b-2 of the Exchange Act.
Large accelerated filer | ☐ | Accelerated filer | ☐ | |||
Non-accelerated filer | ☒ | Smaller reporting company | ☒ | |||
Emerging growth company | ☐ |
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
EXPLANATORY NOTE
This Registration Statement on Form S-8, relating to the 2016 Employee Stock Purchase Plan (the 2016 ESPP) of Syros Pharmaceuticals, Inc. (the Registrant) and the 2022 Inducement Stock Incentive Plan, as amended (the 2022 Inducement Plan), is being filed for the purpose of registering additional securities of the same class as other securities for which a Registration Statement on Form S-8 has previously been filed and is effective. Accordingly, this Registration Statement incorporates by reference the contents of the following Registration Statements on Form S-8 filed by the Registrant with the Securities and Exchange Commission (SEC) relating to the 2016 ESPP and the 2022 Inducement Plan, except in each case the contents of Item 8, Exhibits thereof, with respect to which the Exhibit Index immediately preceding the exhibits attached hereto is incorporated by reference.
SEC File No. | Date Filed with SEC | |
333-212363 | June 30, 2016 | |
333-216821 | March 20, 2017 | |
333-223574 | March 12, 2018 | |
333-230116 | March 7, 2019 | |
333-236895 | March 5, 2020 | |
333-253861 | March 4, 2021 | |
333-263555 | March 15, 2022 |
Item 8. | Exhibits. |
The following exhibits are incorporated herein by reference:
Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on this 2nd day of March, 2023.
SYROS PHARMACEUTICALS, INC. | ||
By: |
/s/ Nancy Simonian, M.D. | |
Nancy Simonian, M.D. | ||
President and Chief Executive Officer |
POWER OF ATTORNEY AND SIGNATURES
We, the undersigned officers and directors of Syros Pharmaceuticals, Inc., hereby severally constitute and appoint Nancy Simonian, M.D. and Jason Haas, and each of them singly, our true and lawful attorneys with full power to them, and each of them singly, to sign for us and in our names in the capacities indicated below, the registration statement on Form S-8 filed herewith and any and all subsequent amendments to said registration statement, and generally to do all such things in our names and on our behalf in our capacities as officers and directors to enable Syros Pharmaceuticals, Inc. to comply with the provisions of the Securities Act of 1933, as amended, and all requirements of the Securities and Exchange Commission, hereby ratifying and confirming our signatures as they may be signed by our said attorneys, or any of them, to said registration statement and any and all amendments thereto.
Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities and on the dates indicated.
Signature | Title | Date | ||
/s/ Nancy Simonian, M.D. Nancy Simonian, M.D. |
President, Chief Executive Officer and Director (principal executive officer) | March 2, 2023 | ||
/s/ Jason Haas Jason Haas |
Chief Financial Officer (principal financial officer and principal accounting officer) | March 2, 2023 | ||
/s/ Peter Wirth Peter Wirth |
Chair of the Board of Directors | March 2, 2023 | ||
/s/ Srinivas Akkaraju, M.D., Ph.D. Srinivas Akkaraju, M.D., Ph.D. |
Director | March 2, 2023 | ||
/s/ Mark J. Alles Mark J. Alles |
Director | March 2, 2023 | ||
/s/ Deborah Dunsire, M.D. Deborah Dunsire, M.D. |
Director | March 2, 2023 | ||
/s/ S. Gail Eckhardt, M.D. S. Gail Eckhardt, M.D. |
Director | March 2, 2023 | ||
/s/ Marsha H. Fanucci Marsha H. Fanucci |
Director | March 2, 2023 |
/s/ Andrew M. Oh Andrew M. Oh |
Director | March 2, 2023 | ||
/s/ Timothy T. Tyson Timothy T. Tyson |
Director | March 2, 2023 | ||
/s/ Richard. A. Young, Ph.D. Richard A. Young, Ph.D. |
Director | March 2, 2023 |
Exhibit 5.1
+1 617 526 6000 (t)
+1 617 526 5000 (f)
wilmerhale.com
March 2, 2023
Syros Pharmaceuticals, Inc.
35 CambridgePark Drive, 4th Floor
Cambridge, MA 02140
Re: | 2016 Employee Stock Purchase Plan |
2022 Inducement Stock Incentive Plan, as amended |
Ladies and Gentlemen:
We have assisted in the preparation of a Registration Statement on Form S-8 (the Registration Statement) to be filed with the Securities and Exchange Commission (the Commission) under the Securities Act of 1933, as amended (the Securities Act), relating to an aggregate of 952,631 shares of common stock, $0.001 par value per share (the Shares), of Syros Pharmaceuticals, Inc., a Delaware corporation (the Company), issuable under the Companys 2016 Employee Stock Purchase Plan and the Companys 2022 Inducement Stock Incentive Plan, as amended (collectively, the Plans).
We have examined the Certificate of Incorporation and By-Laws of the Company, each as amended and restated to date, and originals, or copies certified to our satisfaction, of all pertinent records of the meetings of the board of directors and stockholders of the Company, the Registration Statement, the Plans and such other documents relating to the Company as we have deemed material for the purposes of this opinion.
In our examination of the foregoing documents, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals, the conformity to original documents of all documents submitted to us as certified, photostatic or other copies, the authenticity of the originals of any such documents and the legal competence of all signatories to such documents.
We assume that the appropriate action will be taken, prior to the offer and sale of the Shares in accordance with the Plans, to register and qualify the Shares for sale under all applicable state securities or blue sky laws.
We express no opinion herein as to the laws of any state or jurisdiction other than the General Corporation Law of the State of Delaware.
It is understood that this opinion is to be used only in connection with the offer and sale of the Shares while the Registration Statement is in effect.
Please note that we are opining only as to the matters expressly set forth herein, and no opinion should be inferred as to any other matters.
Based on the foregoing, we are of the opinion that the Shares have been duly authorized for issuance and, when the Shares are issued and paid for in accordance with the terms and conditions of the Plans, the Shares will be validly issued, fully paid and nonassessable.
We hereby consent to the filing of this opinion with the Commission in connection with the Registration Statement in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act. In giving such consent, we do not hereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Commission.
March 2, 2023
Page 2
Very truly yours, |
/s/ Wilmer Cutler Pickering Hale and Dorr LLP |
WILMER CUTLER PICKERING HALE AND DORR LLP |
Exhibit 23.2
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2016 Employee Stock Purchase Plan and the 2022 Inducement Stock Incentive Plan of Syros Pharmaceuticals, Inc. of our report dated March 2, 2023, with respect to the consolidated financial statements of Syros Pharmaceuticals, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2022, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Boston, Massachusetts
March 2, 2023
Exhibit 107
Calculation of Filing Fee Tables
Form S-8
(Form Type)
Syros Pharmaceuticals, Inc.
(Exact Name of Registrant as Specified in its Charter)
Table 1Newly Registered Securities
Security Type |
Security Class Title |
Fee Calculation Rule |
Amount Registered (1) |
Proposed Maximum Offering Price Per Unit |
Maximum Offering Price |
Fee Rate |
Amount of Registration Fee | |||||||
Equity | Common Stock, $0.001 par value per share |
Other | 952,631 (2) | $3.63 (3) | $3,458,050.53 (3) | $110.20 per $1,000,000 |
$381.08 | |||||||
Total Offering Amounts | $3,458,050.53 | $381.08 | ||||||||||||
Total Fee Offsets | $ | |||||||||||||
Net Fee Due | $381.08 |
(1) | In accordance with Rule 416 under the Securities Act of 1933, as amended (the Securities Act), this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions. |
(2) | Consists of (i) 202,631 shares issuable under the 2016 Employee Stock Purchase Plan pursuant to such plans evergreen provision and (ii) 750,000 shares issuable under the 2022 Inducement Stock Incentive Plan, as amended. |
(3) | Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act, and based upon the average of the high and low prices of the registrants common stock as reported on the Nasdaq Global Select Market on February 27, 2023. |