Revenue - Revenue by Major Species (Details) - USD ($) $ in Millions		12 Months Ended
		Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenue from External Customer [Line Items]
Revenues		$ 8,080	$ 7,776	$ 6,675
Operating Segments | United States Segment
Revenue from External Customer [Line Items]
Revenues		4,313	4,042	3,557
Operating Segments | International Segment
Revenue from External Customer [Line Items]
Revenues	[1]	3,681	3,652	3,035
Livestock
Revenue from External Customer [Line Items]
Revenues		2,791	3,005	2,940
Livestock | United States Segment
Revenue from External Customer [Line Items]
Revenues		972	1,052	1,166
Livestock | International Segment
Revenue from External Customer [Line Items]
Revenues		1,819	1,953	1,774
Companion Animal
Revenue from External Customer [Line Items]
Revenues		5,203	4,689	3,652
Companion Animal | United States Segment
Revenue from External Customer [Line Items]
Revenues		3,341	2,990	2,391
Companion Animal | International Segment
Revenue from External Customer [Line Items]
Revenues		1,862	1,699	1,261
Contract Manufacturing and Human Health Diagnostics [Member]
Revenue from External Customer [Line Items]
Revenues		$ 86	$ 82	$ 83

[1] Revenue denominated in euros was $774 million in 2022, $814 million in 2021 and $718 million in 2020.