UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a)

of the Securities Exchange Act of 1934

(Amendment No.        )

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¨ Definitive Proxy Statement

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¨  Soliciting Material Pursuant to §240.14a-12

Zoetis Inc.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

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Your Vote Counts! ZOETIS INC. ATTN: CORPORATE SECRETARY 10 SYLVAN WAY PARSIPPANY, NJ 07054 ZOETIS INC. Vote Virtually at the Annual Shareholder Meeting* May 19, 2022 8:00 AM, EDT Virtually at: www.virtualshareholdermeeting.com/ZTS2022 *Please check the meeting materials for any special requirements for meeting attendance. Smartphone users Point your camera here and vote without entering a control number V1.1 For complete information and to vote, visit www.ProxyVote.com Control # D66671-P65350-Z81660 Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 5, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. You invested in ZOETIS INC. and it’s time to vote! You have the right to vote on the proposals being presented at the Annual Shareholder Meeting. This is an important notice regarding the availability of proxy material for the Annual Shareholder Meeting to be held on May 19, 2022. 2022 Annual Shareholder Meeting Vote by May 18, 2022 11:59 PM EDT. For shares held in an employee stock or retirement benefit plan, vote by May 16, 2022 11:59 PM EDT.

THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming annual shareholder meeting. Please follow the instructions on the reverse side to vote these important matters. Vote at www.ProxyVote.com Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. Voting Items Board Recommends D66672-P65350-Z81660 1. Election of Directors Nominees: 1c. Michael B. McCallister 1a. Paul M. Bisaro 2. Advisory vote to approve our executive compensation. 1b. Frank A. D’Amelio 3. To approve an Amendment and Restatement of our 2013 Equity and Incentive Plan. 4. Ratification of appointment of KPMG LLP as our independent registered public accounting firm for 2022. 5. To approve an amendment to our Restated Certificate of Incorporation to eliminate supermajority voting provisions and certain provisions related to Pfizer Inc. 6. To approve an amendment to our Restated Certificate of Incorporation to declassify the Board of Directors. 7. Shareholder proposal regarding electing each director annually. NOTE: Such other business as may properly come before the Annual Shareholder Meeting or any adjournment thereof. For For For For For For For For Abstain