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                              December 2, 2020

       Kevin J. Knopp
       Chief Executive Officer
       908 Devices Inc.
       645 Summer Street
       Boston, MA 02210

                                                        Re: 908 Devices Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed November 25,
2020
                                                            Amendment No. 1 to
Registration Statement on Form S-1
                                                            Filed December 1,
2020
                                                            File No. 333-250954

       Dear Mr. Knopp:

               We have reviewed your registration statement and have the
following comment. Please
       respond to this letter by amending your registration statement and
providing the requested
       information. If you do not believe our comment applies to your facts and
circumstances or do
       not believe an amendment is appropriate, please tell us why in your
response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to this comment, we may have additional comments.

       Registration Statement on Form S-1 filed November 25, 2020

       Description of Capital Stock
       Choice of Forum, page 143

   1.                                                   Refer to comment 13 of
our October 30, 2020 letter and your disclosure indicating your
                                                        Delaware Court of
Chancery forum selection provision does not apply to claims arising
                                                        under the Securities
Act or Exchange Act. Please revise Section 8 of of your amended and
                                                        restated by-laws filed
as Exhibit 3.5 to clearly state that this provision does not apply to
                                                        claims arising under
the Securities Act or Exchange Act. Additionally, Section 8 does not
                                                        reflect the federal
forum selection provision described on page 143. Please revise to
                                                        address this
inconsistency.
               We remind you that the company and its management are
responsible for the accuracy
       and adequacy of their disclosures, notwithstanding any review, comments,
action or absence of
       action by the staff.
 Kevin J. Knopp
908 Devices Inc.
December 2, 2020
Page 2

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

        You may contact Christine Torney at (202) 551-3652 or Brian Cascio at
(202) 551-
3676 if you have questions regarding the financial statements and related
matters. Please contact
Abby Adams at (202) 551-6902 or Christine Westbrook at (202) 551-5019 with any
other
questions.



                                                            Sincerely,
FirstName LastNameKevin J. Knopp
                                                            Division of
Corporation Finance
Comapany Name908 Devices Inc.
                                                            Office of Life
Sciences
December 2, 2020 Page 2
cc:       Michael J. Minihan, Esq.
FirstName LastName