Exhibit 107

Calculation of Registration Fee

Form S-8

(Form Type)

Semler Scientific, Inc.

(Exact name of registrant as specified in its charter)

Newly Registered Securities

Security Type	Security Class Title	Fee Calculation Rule	Amount Registered(1)		Proposed Maximum Offering Price Per Share(2)		Maximum Aggregate Offering Price		Fee Rate		Amount of Registration Fee
Equity	Common Stock, $0.001 par value per share, 2014 Stock Incentive Plan	Rule 457(c) and Rule 457(h)		1,176,563	$	48.08	$	56,569,149.04	$	0.0000927	$	5,243.96

(1) Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement shall also cover any additional shares of the registrant’s common stock, $0.001 par value per share, which become issuable under the under the Semler Scientific, Inc. 2014 Stock Incentive Plan by reason of any stock dividend, stock split, recapitalization or any other similar transaction effected without the receipt of consideration that results in an increase in the number of the registrant’s outstanding shares of common stock.

(2) The price of $48.08 per share, which is the average of the high and low sale prices of the common stock on the Nasdaq Stock Market on March 4, 2022, is set forth solely for purposes of calculating the registration fee pursuant to Rules 457(c) and (h) of the Securities Act.