Stock-Based Compensation (Tables)

3 Months Ended

Mar. 31, 2020

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

Schedule of Stock-Based Compensation Expense Related to Equity Awards Granted to Employees and Consultants

The following table sets forth stock-based compensation expense related to equity awards granted to employees and consultants for all periods presented (in thousands):

	Three Months Ended March 31,
	2020		2019
Research and development	$	5,192	$	2,963
Selling, general and administrative		5,560		4,018
Total	$	10,752	$	6,981

Summary of Stock Option and Other Equity Award Activity Under Plans

The following summarizes option and other equity award activity under the 2012 Equity Incentive Plan and 2015 Stock Option and Incentive Plan: 

	Shares Subject to			Weighted Average
	Outstanding Options			Exercise Price per Share
Balance at December 31, 2019		4,574,158		$	31.81
Options granted		801,937			70.08
Options exercised		(107,870	)		16.88
Options canceled/forfeited		(27,486	)		44.50
Balance at March 31, 2020		5,240,739			37.91
	Shares Subject to			Weighted Average
	Outstanding Awards			Grant Date Fair Value
Balance at December 31, 2019		741,096		$	46.59
RSUs awarded		333,324			70.09
RSUs released		(125,243	)		43.19
RSUs forfeited		(8,004	)		47.68
Balance at March 31, 2020		941,173			55.36