Sanofi License and Collaboration Agreement - Changes in Contract Liabilities (Details) $ in Thousands	3 Months Ended
Mar. 31, 2018 USD ($)
Contract liabilities:
Deferred revenue, Balance at Beginning of Period	$ 33,558
Deferred revenue, Additions	0
Deferred revenue, Deductions	(5,331)
Deferred revenue, Balance at End of Period	$ 28,227

Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable, classified as current.

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 2
-URI http://asc.fasb.org/extlink&oid=82913815&loc=SL49130532-203044

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 45
-Paragraph 1
-URI http://asc.fasb.org/extlink&oid=82913815&loc=SL49130531-203044

Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 606
-SubTopic 10
-Section 50
-Paragraph 8
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=109196051&loc=SL49130549-203045

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Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant