Basis of Presentation and Significant Accounting Policies (Tables)

3 Months Ended

Mar. 31, 2018

Revenue Initial Application Period Cumulative Effect Transition [Line Items]

Summary of Cash Balance Affected due to Implementation of ASU 2016-18

The following table summarizes the cash balances that were affected due to the Company’s implementation of ASU 2016-18 (in thousands):

Condensed Consolidated Statement of Cash Flows

	March 31, 2018		December 31, 2017		March 31, 2017		December 31, 2016
	As Revised		As Revised		As Revised		As Revised
Cash and cash equivalents	$	183,865	$	224,571	$	135,594	$	135,797
Restricted cash – noncurrent		286		286		259		259
Total cash, cash equivalents and restricted cash	$	184,151	$	224,857	$	135,853	$	136,056

Accounting Standards Update 2014-09

Revenue Initial Application Period Cumulative Effect Transition [Line Items]

Summary of Financial Statement Line Items Affected due to Implementation of Topic 606

The following tables summarize the financial statement line items that were affected due to the Company’s implementation of ASC 606 (in thousands, except for share and per share amounts):

Condensed Consolidated Balance Sheet

	As of December 31, 2017
	As Originally Reported			Effect of Change			As Revised
Deferred revenue - current	$	22,500		$	11,058		$	33,558
Accumulated deficit	$	(123,797	)	$	(11,058	)	$	(134,855	)

Condensed Consolidated Statement of Operations and Comprehensive Loss

	Three Months Ended March 31, 2017
	As Originally Reported			Effect of Change			As Revised
Collaboration and license revenue	$	5,625		$	(3,215	)	$	2,410
Operating expenses:
Research and development		11,917			—			11,917
General and administrative		5,476			—			5,476
Total operating expenses		17,393			—			17,393
Loss from operations		(11,768	)		(3,215	)		(14,983	)
Interest and other income, net		221			—			221
Net loss		(11,547	)		(3,215	)		(14,762	)
Other comprehensive loss		(55	)		—			(55	)
Comprehensive loss		(11,602	)		(3,215	)		(14,817	)
Net loss attributable to common stockholders	$	(11,547	)	$	(3,215	)	$	(14,762	)
Net loss per share attributable to common stockholders,    basic and diluted	$	(0.37	)	$	(0.10	)	$	(0.47	)
Weighted average number of shares used to compute net loss    per share attributable to common stockholders, basic and diluted		31,089,310			31,089,310			31,089,310

Condensed Consolidated Statement of Cash Flows

	Three Months Ended March 31, 2017
	As Originally Reported			Effect of Change			As Revised
Net loss	$	(11,547	)	$	(3,215	)	$	(14,762	)
Adjustments to reconcile net loss to net cash used in operating activities:
Deferred revenue	$	(5,625	)	$	3,215		$	(2,410	)
Cash, cash equivalents and restricted cash, beginning of period	$	135,797		$	259		$	136,056
Cash, cash equivalents and restricted cash, end of period	$	135,594		$	259		$	135,853