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Accrued Expenses (Details) - USD ($)
$ in Thousands
Dec. 31, 2015
Dec. 31, 2014
Payables and Accruals [Abstract]    
Compensation and related benefits $ 2,237 $ 2,753
Development, site costs, and contract manufacturing 734 2,567
Legal, audit and tax services 1,540 829
Consulting 813 793
Other expenses 2,242 712
Accrued expenses $ 7,566 $ 7,654