10-Q

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q



(Mark One)
	x	QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2015



	o	TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission file number: 001-35890

OVASCIENCE, INC.

(Exact name of registrant as specified in its charter)



	Delaware		45-1472564
	(State or other jurisdiction of incorporation or organization)		(I.R.S. Employer Identification No.)
			(I.R.S. Employer Identification No.)



9 4th Avenue
Waltham, Massachusetts		02451
(Address of principal executive offices)		(Zip Code)

617-500-2802

(Registrant’s telephone number, including area code)

215 First Street, Suite 240

Cambridge, Massachusetts 02142

(Former name, former address and former fiscal year, if changed since last report)

Indicate by check mark whether the registrant: (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes x No o

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yes x No o

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):



Large accelerated filer o		Accelerated filer x

Non-accelerated filer o		Smaller reporting company o
(Do not check if a smaller reporting company)

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes o

No x

As of November 3, 2015, there were 27,278,284 shares of the registrant’s Common Stock, par value $0.001 per share, outstanding.

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OVASCIENCE, INC.

Quarterly Report on Form 10-Q

For the Quarterly Period Ended September 30, 2015

INDEX



		Page

	Part I. Financial Information

Item 1.	Financial Statements (Unaudited)	3

	Condensed Consolidated Balance Sheets	3

	Condensed Consolidated Statements of Operations and Comprehensive Loss	4

	Condensed Consolidated Statements of Cash Flows	5

	Notes to Unaudited, Condensed Consolidated Financial Statements	6

Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	13

Item 3.	Quantitative and Qualitative Disclosures About Market Risk	20

Item 4.	Controls and Procedures	21

	Part II. Other Information

Item 1.	Legal Proceedings	21

Item 1A.	Risk Factors	22

Item 6.	Exhibits	22

Signatures

Exhibit Index

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Part I. Financial Information

Item 1. Financial Statements

OvaScience, Inc.

Condensed Consolidated Balance Sheets

(Unaudited)

(In thousands, except share and per share data)



	As of September 30,			As of December 31,
	2015			2014
Assets
Current assets:
Cash and cash equivalents	$	50,842		$	6,414
Short-term investments	90,830			53,817
Prepaid expenses and other current assets	3,541			1,647
Restricted cash	109			—
Total current assets	145,322			61,878
Property and equipment, net	6,717			3,367
Investment in joint venture	241			—
Restricted cash	527			197
Other long-term assets	—			130
Total assets	$	152,807		$	65,572
Liabilities and stockholders’ equity
Current liabilities:
Accounts payable	$	4,156		$	2,520
Accrued expenses and other current liabilities	5,707			7,654
Total current liabilities	9,863			10,174
Other non-current liabilities	358			73
Total liabilities	10,221			10,247

Stockholders’ equity:
Preferred stock, $0.001 par value; 5,000,000 shares authorized, no shares issued and outstanding	—			—
Common stock, $0.001 par value; 100,000,000 shares authorized; 27,276,410 and 24,413,666 shares issued at September 30, 2015 and December 31, 2014, respectively; 27,276,410 and 24,084,637 shares outstanding at September 30, 2015 and December 31, 2014, respectively	27			24
Additional paid-in capital	289,947			150,025
Accumulated other comprehensive loss	(72		)	(26		)
Accumulated deficit	(147,316		)	(94,698		)
Total stockholders’ equity	142,586			55,325
Total liabilities and stockholders’ equity	$	152,807		$	65,572

See accompanying notes.

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OvaScience, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(Unaudited)

(In thousands, except per share data)



	Three Months Ended September 30,						Nine Months Ended September 30,
	2015			2014			2015			2014
Revenues	$	75		$	—		$	120		$	—
Costs and expenses:
Costs of revenues	940			—			1,091			—
Research and development	3,998			5,325			13,766			14,511
Selling, general and administrative	12,909			7,074			37,022			15,133
Total costs and expenses	17,847			12,399			51,879			29,644
Loss from operations	(17,772		)	(12,399		)	(51,759		)	(29,644		)
Interest income (expense), net	141			(25		)	286			(109		)
Other income, net	25			24			31			38
Loss from equity method investment	(316		)	(523		)	(1,176		)	(915		)
Net loss	$	(17,922	)	$	(12,923	)	$	(52,618	)	$	(30,630	)
Net loss per share—basic and diluted	$	(0.66	)	$	(0.54	)	$	(1.95	)	$	(1.38	)
Weighted average number of shares used in net loss per share—basic and diluted	27,267			23,766			27,020			22,192
Net loss	$	(17,922	)	$	(12,923	)	$	(52,618	)	$	(30,630	)
Other comprehensive loss:
Unrealized (losses) gains on available-for-sale securities	22			(16		)	(46		)	(34		)
Comprehensive loss	$	(17,900	)	$	(12,939	)	$	(52,664	)	$	(30,664	)

See accompanying notes.

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OvaScience, Inc.

Condensed Consolidated Statements of Cash Flows

(Unaudited)

(In thousands)



	Nine Months Ended September 30,
	2015			2014
Cash flows from operating activities:
Net loss	$	(52,618	)	$	(30,630	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	748			262
Amortization of premium on debt securities	792			638
Stock-based compensation expense	14,417			6,035
Net loss on equity method investment	1,176			915
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,894		)	(798		)
Accounts payable	(139		)	1,893
Accrued expenses and other non-current liabilities	(1,449		)	1,621
Net cash used in operating activities	(38,967		)	(20,064		)
Cash flows from investing activities:
Investment in joint venture	(1,500		)	(1,500		)
Purchases of property, plant and equipment	(2,323		)	(1,469		)
Maturities of short-term investments	41,104			16,820
Sales of short-term investments	3,117			6,418
Purchases of short-term investments	(82,072		)	(57,603		)
Increase in restricted cash	(439		)	(109		)
Net cash used in investing activities	(42,113		)	(37,443		)
Cash flows from financing activities:
Net proceeds from the issuance of common stock	124,063			51,554
Issuances of common stock under benefit plans, net of withholding taxes paid	1,445			—
Net cash provided by financing activities	125,508			51,554
Net increase (decrease) in cash and cash equivalents	44,428			(5,953		)
Cash and cash equivalents at beginning of period	6,414			18,078
Cash and cash equivalents at end of period	$	50,842		$	12,125

See accompanying notes.

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OvaScience, Inc.

Notes to Unaudited, Condensed Consolidated Financial Statements

1. Organization and basis of presentation

OvaScience, Inc., incorporated on April 5, 2011 as a Delaware corporation, is a global fertility company developing proprietary potential treatments for female infertility based on scientific discoveries about the existence of egg precursor, or EggPC^SM, cells. As used in these condensed consolidated financial statements, the terms “OvaScience,” “the Company,” “we,” “us,” and “our” refer to the business of OvaScience, Inc. and its wholly owned subsidiaries. Our operations to date have been limited to organizing and staffing our company, business planning, raising capital, acquiring and developing our technology, identifying potential fertility treatments, developing the AUGMENT^SM treatment, launching the AUGMENT treatment in select international in vitro fertilization (IVF) clinics, researching and developing the OvaPrime^SM treatment and the OvaTure^SM treatment, and determining the regulatory and development path for our fertility treatments. We have commenced our planned principal operations but have not generated any significant revenues to date.

We are subject to a number of risks similar to other life science companies, including, but not limited to, the need to obtain adequate additional funding, possible failure to provide our treatments to IVF clinics to gain clinical experience in select countries outside of the United States, the need to obtain marketing approval for certain of our treatments, competitors developing new technological innovations, the need to successfully commercialize and gain market acceptance of our treatments and protection of proprietary technology. If we do not successfully commercialize our treatments, we will be unable to generate treatment revenue or achieve profitability. As of September 30, 2015 we had an accumulated deficit of approximately $147.3 million.

Liquidity

We have incurred annual net operating losses in each year since our inception. We have generated limited treatment revenues related to our primary business purpose and have financed our operations primarily through private placements of our preferred stock and public sales of our common stock. We have launched one fertility treatment, the AUGMENT treatment, in select international IVF clinics and have two potential treatments in development. We have devoted substantially all of our financial resources and efforts to the launch of the AUGMENT treatment, raising capital, and research and development. We expect to continue to incur significant expenses and operating losses for at least the next several years.

2. Basis of presentation and significant accounting policies

Unaudited interim financial data

The accompanying unaudited condensed consolidated balance sheet as of September 30, 2015, the statements of operations and comprehensive loss for the three and nine months ended September 30, 2015 and 2014, and the statements of cash flows for the nine months ended September 30, 2015 and 2014, and the related interim information contained within the notes to the financial statements, have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission for interim financial information. Accordingly, they do not include all of the information and the notes required by U.S. generally accepted accounting principles for complete financial statements. In the opinion of management, the unaudited interim financial statements reflect all adjustments, consisting of normal and recurring adjustments, necessary for the fair presentation of our financial position at September 30, 2015, results of our operations for the three and nine months ended September 30, 2015 and 2014 and our cash flows for the nine months ended September 30, 2015 and 2014. The results for the three and nine months ended September 30, 2015 are not necessarily indicative of future results.

Principles of consolidation

These condensed consolidated financial statements include the accounts of OvaScience and the accounts of our wholly-owned subsidiaries. All intercompany transactions have been eliminated in consolidation.

Use of estimates

These condensed consolidated financial statements are presented in conformity with U.S. generally accepted accounting principles, which require management to make estimates and assumptions that affect the amounts reported in the condensed consolidated financial statements and accompanying notes. Actual results could differ from such estimates.

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Selling, general and administrative costs

We expense selling, general and administrative costs as incurred. Selling, general and administrative costs consist of ongoing costs to run our daily operations and internal costs to support the international launch of the AUGMENT^SM treatment.

Net loss per share

Basic and diluted net loss per common share is calculated by dividing net loss by the weighted average number of shares outstanding during the period. Potentially dilutive shares, including outstanding stock options and unvested restricted stock, are only included in the calculation of diluted net loss per share when their effect is dilutive.

The amounts in the table below were excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in thousands):



	As of September 30,
	2015	2014
Outstanding stock options and restricted stock units	4,765	2,970
Unvested Founders’ stock	—	494
Total	4,765	3,464

Summary of significant accounting policies

Our other significant accounting policies are described in Note 2, “Summary of Significant Accounting Policies,” in our Annual Report on Form 10-K for the year ended December 31, 2014.

3. OvaXon joint venture

In December 2013, we entered into a joint venture with Intrexon Corporation (“Intrexon”) to leverage Intrexon’s synthetic biology technology platform and OvaScience’s technology relating to EggPC cells to focus on developing significant improvements in human and animal health. We and Intrexon formed OvaXon, LLC (“OvaXon”) to conduct the joint venture. Each party contributed $1.5 million of cash to OvaXon, each has a 50% equity interest and research and development costs and profits will be split accordingly. Each party will also have 50% control over OvaXon and any disputes between us and Intrexon will be resolved through arbitration, if necessary.

We have recorded losses from equity method investments related to OvaXon of $0.3 million and $1.2 million for the three and nine months ended September 30, 2015, respectively. We have recorded losses from equity method investments related to OvaXon of $0.5 million and $0.9 million for the three and nine months ended September 30, 2014, respectively. Each party contributed an additional $1.5 million during the nine months ended September 30, 2015.

We consider OvaXon a variable interest entity. OvaXon does not have a primary beneficiary as both we and Intrexon have equal ability to direct the activities of OvaXon through membership in a Joint Steering Committee and an Intellectual Property Committee and 50% voting rights. OvaXon has been accounted for under the equity method and is not consolidated. This analysis and conclusion will be updated annually to reflect any changes in ownership or control over OvaXon.

4. Fair value

The fair value of our financial assets and liabilities reflects our estimate of amounts that we would have received in connection with the sale of such assets or paid in connection with the transfer of such liabilities in an orderly transaction between market participants at the measurement date. In connection with measuring the fair value of our assets and liabilities, we seek to maximize the use of observable inputs (market data obtained from independent sources) and to minimize the use of unobservable inputs (our assumptions about how market participants would price assets and liabilities). We use the following fair value hierarchy to classify assets and liabilities based on the observable inputs and unobservable inputs we used to value our assets and liabilities:


•	Level 1—quoted prices (unadjusted) in active markets for identical assets or liabilities.

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•	Level 2—quoted prices for similar assets and liabilities in active markets or inputs that are observable for the asset or liability, either directly or indirectly through market corroboration, for substantially the full term of the financial instrument.


•	Level 3—unobservable inputs based on our assumptions used to measure assets and liabilities at fair value.

For fixed income securities, we reference pricing data supplied by our custodial agent and nationally known pricing vendors, using a variety of daily data sources, largely readily-available market data and broker quotes. The prices provided by third-party pricing services are validated by reviewing their pricing methods and obtaining market values from other pricing sources. After completing these validation procedures, we did not adjust or override any fair value measurements provided by the pricing services as of September 30, 2015 or December 31, 2014.

We review investments for other-than-temporary impairment whenever the fair value of an investment is less than the amortized cost and evidence indicates that an investment’s carrying amount is not recoverable within a reasonable period of time. To determine whether an impairment is other-than-temporary, we consider the intent to sell, or whether it is more likely than not that we will be required to sell the investment before recovery of the investment’s amortized cost basis. Evidence considered in this assessment includes reasons for the impairment, compliance with our investment policy, the severity and the duration of the impairment and changes in value subsequent to period end. As of September 30, 2015 and December 31, 2014, there were no investments with a fair value that was significantly lower than the amortized cost basis.

The following tables provide our assets and liabilities that are measured at fair value on a recurring basis as of September 30, 2015 and December 31, 2014 (in thousands):



Description	Balance as of September 30, 2015		Level 1		Level 2		Level 3
Assets:
Cash and money market funds	$	50,842	$	50,842	$	—	$	—
Corporate debt securities (including commercial paper)	90,830		—		90,830		—
Total assets	$	141,672	$	50,842	$	90,830	$	—



Description	Balance as of December 31, 2014		Level 1		Level 2		Level 3
Assets:
Cash and money market funds	$	6,414	$	6,414	$	—	$	—
Corporate debt securities (including commercial paper)	53,817		—		53,817		—
Total assets	$	60,231	$	6,414	$	53,817	$	—

Cash and cash equivalents, prepaid expenses, accounts payable and accrued expenses are carried at amounts that approximate fair value due to their short-term maturities.

5. Cash, cash equivalents and short-term investments

The following tables summarize our cash, cash equivalents and short-term investments at September 30, 2015 and December 31, 2014 (in thousands):

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September 30, 2015	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Cash and money market funds	$	50,842	$	—	$	—		$	50,842
Corporate debt securities	0		0		0			0
Due in one year or less	59,695		7		(50		)	59,652
Due in two years or less	31,207		7		(36		)	31,178
Total	$	141,744	$	14	$	(86	)	$	141,672
Reported as:
Cash and cash equivalents	$	50,842	$	—	$	—		$	50,842
Short-term investments	90,902		14		(86		)	90,830
Total	$	141,744	$	14	$	(86	)	$	141,672



December 31, 2014	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Value
Cash and money market funds	$	6,414	$	—	$	—		$	6,414
Corporate debt securities	0		0		0			0
Due in one year or less	53,843		2		(28		)	53,817
Total	$	60,257	$	2	$	(28	)	$	60,231
Reported as:
Cash and cash equivalents	$	6,414	$	—	$	—		$	6,414
Short-term investments	53,843		2		(28		)	53,817
Total	$	60,257	$	2	$	(28	)	$	60,231

At September 30, 2015 and December 31, 2014 we held 27 and 32 debt securities that had been in an unrealized loss position for less than 12 months, respectively. We held no investments that had been in a continuous unrealized loss position for 12 months or longer. At September 30, 2015 and December 31, 2014 the aggregate fair value of these securities was $54.8 million and $44.2 million, respectively. We evaluated our securities for other-than-temporary impairments based on quantitative and qualitative factors, and we considered the decline in market value for the 27 debt securities as of September 30, 2015 to be primarily attributable to current economic and market conditions. We will likely not be required to sell these securities, and we do not intend to sell these securities before the recovery of their amortized cost bases, which recovery is expected within the next 12 months. Based on our analysis, we do not consider these investments to be other-than-temporarily impaired as of September 30, 2015.

As of September 30, 2015, we held $15.0 million in financial institution debt securities and other corporate debt securities located in Canada, the United Kingdom and Australia. As of December 31, 2014, we held $7.5 million in financial institution debt securities and other corporate debt securities located in Canada, the United Kingdom, and France. Based on our analysis, we do not consider these investments to be other-than-temporarily impaired as of September 30, 2015.

We had immaterial realized gains and no realized losses or other-than-temporary impairments on our short-term investments for the three and nine months ended September 30, 2015. We had no realized gains or losses or other-than-temporary impairments on our short-term investments for the three months ended September 30, 2014 and immaterial realized gains and no losses or other-than-temporary impairments on our short-term investments for the nine months ended September 30, 2014.

6. Property and equipment

Property and equipment and related accumulated depreciation are as follows (in thousands):

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	As of September 30,			As of December 31,
	2015			2014
Laboratory equipment	$	6,033		$	4,093
Furniture	451			207
Computer equipment	189			7
Leasehold improvements	1,927			198
Total property and equipment, gross	8,600			4,505
Less: accumulated depreciation	(1,883		)	(1,138		)
Total property and equipment, net	$	6,717		$	3,367

We recorded depreciation and amortization expense of $0.3 million and $0.7 million for the three and nine months ended September 30, 2015, respectively. We recorded depreciation and amortization expense of $0.1 million and $0.3 million for the three and nine months ended September 30, 2014, respectively.

7. Common stock

In January 2015, we issued and sold in an underwritten public offering an aggregate of 2,645,000 shares of our common stock at $50 per share, which included 345,000 shares that represented the full exercise of an option to purchase additional shares granted to the underwriters in connection with the offering. The shares included in this offering were registered under the Securities Act of 1933, as amended, or the Securities Act, pursuant to a registration statement on Form S-3 (File No. 333-200040) that the Securities and Exchange Commission declared effective on November 21, 2014. The offering resulted in $124.1 million of net proceeds, after deducting underwriting discounts and commissions and other offering expenses payable by us.

In March 2014, we issued and sold in a public offering an aggregate of 5,518,630 shares of our common stock at $10.00 per share, which included 518,630 shares that represented the partial exercise of an overallotment option granted to the underwriters in connection with the offering. The shares included in this offering were registered under the Securities Act of 1933, as amended, pursuant to a registration statement Form S-3 (File No. 333-190939) that the Securities and Exchange Commission declared effective on September 10, 2013. The offering resulted in $51.7 million of net proceeds, after deducting underwriting discounts and commissions and other offering expenses payable by us.

8. Stock-based compensation

Founders’ stock

A summary of our Founders’ stock activity and related information is as follows:



	Shares
Unvested at December 31, 2014	329,021
Granted	—
Vested	(164,515	)
Unvested at March 31, 2015	164,506
Granted	—
Vested	(164,506	)
Unvested at June 30, 2015	—
Granted	—
Vested	—
Unvested at September 30, 2015	—

We record stock-based compensation expense for the common stock subject to repurchase based on the grant date intrinsic value for employees and the vesting date intrinsic value for non-employees. All of the restricted shares were issued at fair value.

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Stock options

A summary of our stock option activity and related information is as follows:



	Shares		Weighted average exercise price per share		Weighted Average Remaining contractual Term (years)	Aggregate intrinsic value (in thousands)
Outstanding at December 31, 2014	3,628,628		$	16.01	9.11	$	102,355
Granted	1,710,100		34.38
Exercised	(199,305	)	8.04
Forfeited / Cancelled	(405,301	)	30.05
Outstanding at September 30, 2015	4,734,122		21.78		8.80	1,239
Exercisable at September 30, 2015	1,164,333		10.49		7.87	1,050
Vested and expected to vest at September 30, 2015	3,942,778		21.19		8.75	1,199

The total intrinsic value (the amount by which the fair market value exceeded the exercise price) of stock options exercised was $0.1 million and $6.6 million for the three and nine months ended September 30, 2015, respectively. The total intrinsic value of stock options exercised was $0.2 million and $1.8 million for the three and nine months ended September 30, 2014, respectively.

The fair value of each stock-based option award is estimated on the grant date using the Black-Scholes option pricing model using the following assumptions:



	Three months ended September 30,		Nine months ended September 30,
	2015	2014	2015	2014
Risk-free interest rate	1.7%	2.1%	1.6% - 2.3%	1.6% - 2.1%
Dividend yield	—	—	—	—
Volatility	72%	84%	72% - 75%	76% - 84%
Expected term (years)	6.1	6.1	5.3 - 9.9	5.3 - 6.1

As of September 30, 2015, we had approximately $40.0 million of total unrecognized compensation cost, net of estimated forfeitures, related to unvested stock options, which we expect to recognize over a weighted-average period of 3.1 years.

During the three months ended September 30, 2015, a senior executive resigned from employment with us. In connection with the separation, all unvested stock options were forfeited. As a result of the forfeiture, we reversed $0.9 million, net, of stock-based compensation expense during the three months ended September 30, 2015.

During the three and nine months ended September 30, 2015, we granted options to purchase 284,500 and 1,710,100 shares of our common stock at weighted average grant date fair values of $10.71 and $21.79 per share, respectively, and with weighted average exercise prices of $16.58 and $34.38 per share, respectively. During the three and nine months ended September 30, 2014, we granted options to purchase 284,000 and 1,451,598 shares of our common stock at weighted average grant date fair values of $11.42 and $7.27 per share, respectively, and with weighted average exercise prices of $15.67 and $10.34 per share, respectively.

Restricted stock units

We granted restricted stock units (“RSUs”) to our Chief Executive Officer in December 2014 and 2012. The RSUs issued at each date included a service-based award that vests evenly over eight quarters and a performance-based award that vests in two one-year tranches upon the achievement of certain performance conditions for the respective year, as determined by our board of directors. The grant date fair value of the service-based awards is based on the closing price of our common stock on the award date and the stock-based compensation expense for these service-based awards are recognized on a straight-line basis over the vesting period. The grant date fair value of the performance-based awards is based on the closing price of our common stock on the date that the performance criteria is established for each tranche and communicated to our Chief

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Executive Officer and the stock-based compensation for these performance-based awards is recognized over the requisite service period.

The following table summarizes the December 9, 2014 award.



Award Type	Number of RSUs Granted	Grant Date Fair Value		RSUs Vested as of September 30, 2015
Service-based	30,902	$	32.36	11,588
Performance-based - Year 1	11,588	$	43.47	—
Performance-based - Year 2	11,588	$	—	—

The number of RSUs granted for the 2014 performance award is reflective of the maximum number of RSUs that can be earned, if the board of directors determines the performance criteria were achieved at 150%. On March 29, 2015 our board of directors established the 2015 performance criteria for the first tranche of the performance-based award and communicated the performance criteria to our Chief Executive Officer. The grant date stock price of these performance-based RSUs was $43.47 per share. As of September 30, 2015, we have determined that certain of the performance criteria are probable of achievement and we are recognizing the related expense for these awards over the requisite service period.

The following table summarizes the December 5, 2012 award.



Award Type	Number of RSUs Granted	Grant Date Fair Value		RSUs Vested as of September 30, 2015
Service-based	128,205	$	7.80	128,205
Performance-based - Year 1	32,052	$	10.00	19,230
Performance-based - Year 2	32,051	$	8.75	32,051

The number of RSUs granted for the 2012 performance award is reflective of the maximum number of RSUs that can be earned, if the board of directors determined the performance criteria were achieved at 100%. On March 20, 2013 our board of directors established the 2013 performance criteria for the first tranche of the performance-based award and communicated the performance criteria to our Chief Executive Officer. In December 2013, certain of the performance criteria were met resulting in a partial vesting of the first tranche award. On February 7, 2014 our board of directors established the 2014 performance criteria for the second tranche of the performance-based award and communicated the performance criteria to our Chief Executive Officer. In December 2014 our board of directors determined that all of the performance criteria had been met resulting in the full vesting of the second tranche award.

The following expense has been recorded for the RSUs.



	Expense Recorded in Three Months Ended September 30,				Expense Recorded in Nine Months Ended September 30,
	2015		2014		2015		2014
	(in 000s)				(in 000s)
December 9, 2014
Service-based	$	123	$	—	$	363	$	—
Performance-based	$	22	$	—	$	135	$	—
	$	145	$	—	$	498	$	—
December 5, 2012
Service-based	$	—	$	122	$	—	$	361
Performance-based	$	—	$	69	$	—	$	192
	$	—	$	191	$	—	$	553

As of September 30, 2015, we had approximately $0.7 million of total unrecognized compensation cost related to the 2014 awards, related to unvested restricted stock units, which we expect to recognize over a weighted-average period of 1.2 years.

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9. Commitments and Contingencies

In May 2015, we entered into a lease agreement for approximately 25,200 square feet of office and laboratory space in a building in Waltham, MA. The term of the lease commenced on June 1, 2015 and extends through November 2020, with an optional additional five year term extension. Future non-cancelable minimum annual lease payments under the lease are expected to be approximately $0.1 million remaining in 2015, $0.9 million in 2016 and 2017, $1.0 million in each of 2018 and 2019, and $0.9 million in 2020. The price per square feet reflected in these amounts is significantly less compared to our existing leases in Cambridge, MA. We have provided a security deposit in the form of a letter of credit in the amount of $0.4 million. The letter of credit is cash collateralized, which has been recorded as long-term restricted cash on the condensed consolidated balance sheet.

In connection with this lease, the landlord is providing a tenant improvement allowance of up to $1.2 million for the costs associated with the construction of tenant improvements for the leased facility. We will account for the allowance incurred as a lease incentive, which will be recorded as a reduction to rent expense over the lease term.

As a result, we have terminated one of our two existing leases in Cambridge, MA and expect to terminate the remaining lease in the fourth quarter of 2015.

Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

This Quarterly Report on Form 10-Q contains forward-looking statements that involve risks and uncertainties. The statements contained in this Quarterly Report on Form 10-Q that are not purely historical are forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Without limiting the foregoing, the words “may,” “shall,” “will,” “should,” “could,” “expects,” “plans,” “intends,” “anticipates,” “believes,” “estimates,” “predicts,” “potential,” “continue,” “target,” “goal”, “seek”, “likely,” “hope” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these words. All forward-looking statements included in this Quarterly Report on Form 10-Q are based on information available to us up to, and including, the date of this document, and we expressly disclaim any obligation to update any such forward-looking statements to reflect events or circumstances that arise after the date hereof. Our actual results could differ materially from those anticipated in these forward-looking statements as a result of certain important factors, including those set forth in this Item 2 — “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” as well as under the heading “Risk Factors” contained in Item 1A of our Annual Report on Form 10-K for the year ended December 31, 2014 and elsewhere in this Quarterly Report on Form 10-Q. You should carefully review those factors and also carefully review the risks outlined in other documents that we file from time to time with the Securities and Exchange Commission, or SEC.

Overview

OvaScience is a global fertility company focused on the discovery, development, and commercialization of new treatment options for women. The current standard of treatment for infertility is in vitro fertilization, or IVF. IVF, however, fails approximately 70% of the time. More women around the world are waiting later in life to start families but unfortunately, fertility decreases as women age. A major cause of infertility, especially in older women, is poor egg health, which is linked to a reduction in the number of functioning mitochondria. Additionally, approximately 25-30% of women who undergo IVF cannot make eggs and some women are unwilling or unable to undergo the hormone stimulation needed to undergo IVF, such as women who have been diagnosed with cancer. Accordingly, women throughout the world are increasingly seeking new treatment options for infertility.

Our patented technology is based on egg precursor, or EggPC^SM, cells, which are immature egg cells found in the protective outer lining of a woman’s ovaries. These immature egg cells have the ability to grow into fresh, young, healthy eggs. The discovery of EggPC cells countered a long-held medical belief that women are born with a set number of eggs, thereby enabling our new fertility treatment options.

Our portfolio of fertility treatment options uses proprietary methods to identify and isolate EggPC cells from a woman’s ovarian tissue. By applying our EggPC technology platform in unique ways, we have commercialized one fertility treatment and are developing two additional fertility treatment options that are designed to improve egg health and revolutionize IVF.

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Our first commercial treatment, the AUGMENT^SM treatment, is specifically designed to improve egg health by supplementing a mitochondrial deficiency and may, in turn, improve IVF success rates. The AUGMENT treatment complements the existing standard of practice for an IVF cycle. With the AUGMENT treatment, energy-producing mitochondria from a woman’s own EggPC cells are added to the woman’s mature eggs during the IVF process to supplement the existing mitochondria. The early data presented by our partner clinics has been very encouraging. The AUGMENT treatment has been launched in select international IVF clinics. Most clinics begin offering the AUGMENT treatment through a preceptorship program, designed to allow the clinic to obtain patient experience and training before making it commercially available.

We anticipate that we will introduce the AUGMENT treatment into new international regions. The AUGMENT treatment is not available in the United States.

The OvaPrime^SM treatment is a potential fertility treatment that could enable a woman to increase her egg reserve. The OvaPrime treatment is designed to replenish a woman’s egg reserve by positioning a patient’s EggPC cells from the protective ovarian lining into the patient’s own ovaries where they may mature into fertilizable eggs. We reported large animal proof-of-concept studies in 2014 and plan to optimize the process and introduce the OvaPrime treatment to patients through a preceptorship program in at least one international region outside of the United States by the end of 2015.

The OvaTure^SM treatment is a potential next-generation IVF treatment that could help a woman produce healthy, young, fertilizable eggs without the need for hormone injections. The OvaTure treatment seeks to mature a woman’s own EggPC cells into eggs outside her body. This potential treatment may be an option for women with compromised eggs, who are unable to make eggs, or who may be unwilling or unable to undergo hormone hyperstimulation, such as women diagnosed with cancer. We established human preclinical proof-of-concept in 2014 by demonstrating that human EggPC cells can be matured into eggs outside of the body, and we plan to optimize the process and define the development pathway for the OvaTure treatment in 2015.

We believe our EggPC technology has the potential to make significant advances in the field of fertility because it is designed to address poor egg health and embryo quality due to age and other causes. We believe our EggPC technology could improve IVF by:

Increasing live birth rates and reducing the number of IVF cycles. By improving egg health, we believe we may increase the percentage of live births and reduce the number of IVF cycles required.

Reducing the incidence of multiple births. By generating higher quality eggs, we believe our EggPC technology may allow for the transfer of fewer embryos per IVF cycle and, as a result, lower the incidence of multiple births and the associated complications.

Lowering the overall cost of the IVF process. If we reduce the number of IVF cycles required for a live birth and the incidence of multiple births, we believe our fertility treatment options may also lower the overall costs associated with the IVF process.

Replenishing the ovary for women who make too few or no eggs. Our OvaPrime treatment is designed to replenish a woman’s egg reserve by transferring a patient’s EggPC cells from the protective ovarian lining into the patient’s own ovaries where they may mature into fertilizable eggs.

Reducing the need for hormonal hyperstimulation. We are designing our OvaTure treatment to mature EggPC cells into fertilizable eggs in vitro, or outside the body. If successful, the OvaTure treatment could reduce, or possibly eliminate, the need for hormonal hyperstimulation for the maturation of multiple oocytes prior to egg retrieval in the IVF process.

Developing new treatments for diseases. OvaXon^SM is a joint venture with Intrexon Corporation, or Intrexon, which is focused on developing significant improvements in human and animal health using our EggPC cell technology and Intrexon’s synthetic biology and high throughput platform for applications.

The AUGMENT Treatment

We have launched the AUGMENT treatment in select international IVF clinics and we anticipate that we will introduce the AUGMENT treatment into new international regions. The AUGMENT treatment is not available in the United States.

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An AUGMENT treatment cycle begins upon our receipt of the patient’s ovarian tissue after biopsy, which is obtained through a biopsy performed by the patient's doctor prior to hormone stimulation. Our proprietary process identifies and isolates the patient’s own EggPC cells, and then the patient’s own mitochondria from these EggPC cells are isolated. The patient’s own mitochondria are then injected into her egg at the time of intracytoplasmic sperm injection, or ICSI. We expect to receive payment before processing tissue and defer revenue until we deliver the mitochondria to the clinic, which is timed with the patient's standard IVF cycle and can stretch from 30 to120 days or more. Within certain of our programs, revenue recognition may be further deferred.

In August 2015, the first published analysis comparing the AUGMENT treatment to standard IVF within the same woman within the same cycle was included in the peer-reviewed Journal of Fertilization: In Vitro- IVF-Worldwide Reproductive Medicine, Genetic & Stem Cell Biology. The analysis demonstrated statistically significant higher rates of embryo selection and transfer with the AUGMENT treatment based on standard embryo quality measures, including preimplantation genetic diagnosis/screening, resulting in statistically significant higher rates of pregnancy. Positive patient experiences with the AUGMENT treatment were presented in June 2015 at a scientific symposium during the European Society of Human Reproduction and Embryology (ESHRE) annual meeting. All the clinics offering the AUGMENT treatment at that time reported improved pregnancy rates in patients with poor egg health and embryo quality and who had undergone multiple prior IVF cycles.

We have established our international headquarters in the United Kingdom to coordinate our international commercial efforts. We recently announced that we are expanding the availability of the AUGMENT treatment to two new regions. We continue to target major international regions for the AUGMENT treatment that combine elements of the following key criteria:

•Key opinion leaders

•High volume IVF clinics

•High quality IVF labs

•Out-of-pocket pay and high average cost per cycle

•Potential for reimbursement by healthcare providers

•Donor egg restrictions

On September 28, 2015, we announced that we do not expect to meet the 1,000 AUGMENT treatment cycles goal for 2015. The AUGMENT treatment patient experience has been positive and we have built strong technical operations, quality and manufacturing; however, we are continuing to enhance our commercial operations and infrastructure to optimize for commercial success. Evolving market dynamics in the fertility space, including recent merger and acquisition activities at the key commercial IVF clinics where the AUGMENT treatment is offered, have hindered our ability to drive major volume, including previously anticipated uptake from reimbursement. Our ability to achieve further growth will depend on continued use of the AUGMENT treatment in our partner clinics in new and existing regions.

We continue to explore the optimal business model for the AUGMENT treatment based on our initial commercial experience. We plan to:


•	pursue broader use, including first line treatment for various egg health and male factor indications;


•	pursue reimbursement for the AUGMENT treatment in regions where traditional IVF is covered, while continuing to focus on out-of-pocket pay opportunities;


•	review the optimal manufacturing model(s) in certain regions, while continuing to utilize onsite manufacturing, to handle demand resulting from expanded indications, ongoing publication of patient experience and broad geographic expansion; and


•	continue to optimize commercial operations and logistics.

Critical Accounting Policies and Significant Judgments and Estimates

The discussion and analysis of our financial condition and results of operations is based on our condensed consolidated financial statements, which have been prepared in accordance with U.S. generally accepted accounting principles. The preparation of our condensed consolidated financial statements requires us to make judgments, estimates and assumptions that affect the amounts reported in the condensed consolidated financial statements and accompanying notes. We evaluate our estimates, on an ongoing basis, including those related to accrued expenses and assumptions in the valuation of stock-based compensation. We base our estimates on historical experience and on various other assumptions that we believe to be reasonable in the circumstances. Actual results could differ from those estimates.

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Refer to Part II, Item 7, “Management’s Discussion and Analysis of Financial Condition and Results of Operations” of our Annual Report on Form 10-K for the year ended December 31, 2014 for a discussion of our critical accounting policies and estimates.

There were no significant changes to our critical accounting policies and estimates in the nine months ended September 30, 2015.

We have irrevocably elected not to follow the extended transition period available to emerging growth companies provided for in Section 7(a)(2)(B) of the Securities Act for complying with new or revised accounting standards.

Results of Operations

The following table summarizes our results of operations for the three and nine months ended September 30, 2015 and 2014, together with the change in these items in thousands of dollars and as a percentage:



	Three Months Ended,					2015 / 2014 Comparison					Nine Months Ended					2015 / 2014 Comparison
	September 30,					Increase / (Decrease)					September 30,					Increase / (Decrease)
	2015		2014			$			%		2015		2014			$			%
Revenues	$	75	$	—		$	75		100	%	$	120	$	—		$	120		100	%
Costs of revenues	940		—			940			100	%	1,091		—			1,091			100	%
Research and development expenses	3,998		5,325			(1,327		)	(25	)%	13,766		14,511			(745		)	(5	)%
Selling, general and administrative expenses	12,909		7,074			5,835			82	%	37,022		15,133			21,889			145	%
Interest income (expense), net	141		(25		)	166			(664	)%	286		(109		)	395			(362	)%
Other income, net	25		24			1			4	%	31		38			(7		)	(18	)%
Loss from equity method investment	316		523			(207		)	(40	)%	1,176		915			261			29	%
Net Loss	$	17,922	$	12,923		$	4,999		39	%	$	52,618	$	30,630		$	21,988		72	%

Revenues

We commenced our first commercial AUGMENT treatment in December 2014 and have recorded $75,000 and $120,000 of treatment revenues in the three and nine months ended September 30, 2015, respectively. During the three and nine months ended September 30, 2015, we continued to transition certain of our partner clinics to commercial centers and, as anticipated, began performing limited commercial AUGMENT treatment cycles, for which we received cash and expect to recognize the associated revenue over the coming quarters. The AUGMENT treatment cycle begins upon our receipt of the patient’s tissue after biopsy. We expect to receive payment before processing tissue and defer treatment revenues until we deliver the mitochondria to the clinic. Based on our experiences to date, the period from receipt of the patient’s tissue to recording revenue is expected to range between 30 and 120 days, the typical timeframe required to perform an IVF cycle. Within certain of our programs, revenue recognition may be further deferred. We did not have significant revenue or deferred revenue in the first nine months of 2015. Our ability to generate additional revenue in the near-term will depend on continued use of the AUGMENT treatment in our partner clinics in new and existing regions.

Costs of Revenues

Costs of revenues for the three and nine months ended September 30, 2015 were $0.9 million and $1.1 million, respectively. To provide our AUGMENT treatment we establish laboratories and hire scientific personnel to process the patient tissue. Therefore, we expect the cost of processing an AUGMENT treatment to decline as these fixed costs will be allocated over a larger number of treatments as we continue our commercial launch. Our costs of revenues include the cost of processing patient tissue that corresponds to treatment revenues for the reporting period. In addition, in the third quarter we recorded a charge of $0.4 million related to the write-off of supplies due to expire prior to commercial use as a result of lower than expected AUGMENT treatment cycles. We recorded revenues related to the AUGMENT treatment and corresponding costs of revenues during the three and nine months ended September 30, 2015. We did not have costs of revenues in the three or nine months ending September 30, 2014.

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Research and Development Expense

The $1.3 million, or 25%, decrease in our research and development expense for the three months ended September 30, 2015 as compared to the three months ended September 30, 2014 was primarily attributable to:


•	A decrease of $0.8 million related to the stock-based compensation expense recorded in the prior year, including $1.1 million for Founders' stock, which was fully expensed in the first quarter of 2015 and will not recur offset by $0.3 million of additional expense driven by the hiring of additional personnel.


•	A decrease of $0.4 million in certain collaboration agreements and research grants, which expired prior to the current period.

The $0.7 million, or 5%, decrease in our research and development expense for the nine months ended September 30, 2015 as compared to the nine months ended September 30, 2014 was primarily attributable to:


•	A decrease of $0.8 million in license fees, resulting from a decrease of $1.0 million for the milestone that became due upon completion of our public offering in the first quarter of 2014, which was offset by $0.2 million for a milestone incurred as a result of our first commercial AUGMENT treatment in the first quarter of 2015.


•	A decrease of $0.4 million related to various legal, travel and laboratory expenses as we transitioned our first

fertility treatment to commercial from research and development during the second half of 2014.


•	A decrease of $0.3 million in employee salaries and compensation as certain costs have transitioned to selling, general and administrative expense with the commercial launch of the AUGMENT treatment.


•	A decrease of $0.3 million in certain collaboration agreements and research grants, which expired prior to the current period.


•	An increase of $1.1 million in stock-based compensation expense driven by the hiring of additional personnel.

We expect research and development expense to increase if our programs successfully advance. We do not believe that the historical costs are indicative of the future costs associated with these programs nor do they represent what any other future treatment program we initiate may cost. Due to the variability in the length of time and scope of activities necessary to develop a fertility treatment and uncertainties related to cost estimates and our ability to commercialize and/or obtain marketing approval for our treatments, accurate and meaningful estimates of the total costs required to bring our treatments to market are not available.

Additionally, because of the risks inherent in discovery and development, we cannot reasonably estimate or know:


•	The nature, timing and estimated costs of the efforts necessary to complete the development of our programs;


•	The anticipated completion dates of these programs; or


•	The period in which material net cash inflows are expected to commence, if at all, from the programs described above and any potential future treatments.

Selling, General and Administrative Expense

Selling, general and administrative costs consist of ongoing costs to run our operations and continue to support the expanding international availability of the AUGMENT treatment. The $5.8 million, or 82%, increase in selling, general and administrative expense for the three months ended September 30, 2015 as compared to the three months ended September 30, 2014 was primarily due to:


•	An increase of $2.6 million for employee compensation and related benefits, including stock-based compensation expense driven by the hiring of additional personnel.


•	An increase of $2.6 million to support our international growth and continued commercial development of the AUGMENT treatment including increases of $1.4 million in consulting, legal and marketing expenses, and $1.2 million in specific AUGMENT commercialization costs.


•	An increase of $0.4 million in facilities expenses.


•	An increase of $0.2 million in accounting, tax and other expenses.

The $21.9 million, or 145%, increase in selling, general and administrative expense for the nine months ended September 30, 2015 as compared to the nine months ended September 30, 2014 was primarily due to:

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•	An increase of $11.3 million for employee compensation and related benefits, including stock-based compensation expense driven by the hiring of additional personnel.


•	An increase of $9.3 million to support our international growth and continued commercial development of the AUGMENT treatment including increases of $4.0 million in consulting, legal and marketing expenses, $2.8 million in specific AUGMENT commercialization costs, $1.6 million in travel and related costs, and $0.9 million associated with setting up labs at our partner clinics.


•	An increase of $0.7 million in facilities expenses.


•	An increase of $0.6 million in accounting, tax and other expenses.

Interest Income (Expense), Net

Interest income, net was $0.1 million for the three months ended September 30, 2015 which included $0.1 million of interest income related to short-term investments. For the three months ended September 30, 2014, interest expense, net included $0.3 million of interest income offset by $0.3 million of short term investment amortization and interest expense incurred to record the final installment payment due to Intrexon at fair value.

Interest income, net was $0.3 million for the nine months ended September 30, 2015 which included $0.3 million of interest income related to short-term investments. Interest expense, net was $0.1 million for the nine months ended September 30, 2014 which included $0.8 million of interest income offset by $0.9 million of short term investment amortization and interest expense incurred to record the final installment payment due to Intrexon at fair value.

Loss from Equity Method Investment

Loss from equity method investment was $0.3 million and $1.2 million for the three and nine months ended September 30, 2015, respectively. Loss from equity method investment was $0.5 million and $0.9 million for the three and nine months ended September 30, 2014, respectively. These losses resulted from our OvaXon joint venture established in December 2013.

Liquidity and Capital Resources

Sources of Liquidity

We have generated limited AUGMENT treatment revenue to date. We have relied on the proceeds from sales of equity securities to fund our operations. Our short-term investments primarily trade in liquid markets, and the average days to maturity of our portfolio as of September 30, 2015 is less than twelve months. Because our fertility treatments are in various stages of development and the outcome of these efforts is uncertain, we cannot estimate the actual amounts necessary to successfully complete the development and commercialization of our treatments or whether or when we may achieve profitability.

Our significant capital resources are as follows (in thousands):



	September 30,		December 31,
	2015		2014
Cash, cash equivalents and short-term investments	$	141,672	$	60,231
Working capital	135,459		51,704



	Nine Months Ended September 30,
	2015		2014
Cash (used in) provided by:
Operating activities	(38,967	)	(20,064	)
Investing activities	(42,113	)	(37,443	)
Capital expenditures (included in investing activities above)	(2,323	)	(1,469	)
Financing activities	125,508		51,554

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Cash Flows

Cash used in operating activities in both of the periods presented was primarily driven by our net loss. Cash flows from operations can vary significantly due to various factors, including changes in the net loss and the timing of disbursements made for accounts payable and accruals.

Cash used in investing activities for the nine months ended September 30, 2015 included purchases of $82.1 million of short-term investments, capital expenditures of $2.3 million, a $1.5 million investment in a joint venture and a $0.4 million increase in restricted cash, which were offset by $41.1 million of proceeds from maturities of short-term investments and $3.1 million in sales of short-term investments. Capital expenditures in the nine months ended September 30, 2015 primarily consisted of laboratory equipment.

Cash used in investing activities for the nine months ended September 30, 2014 included purchases of $57.6 million of short-term investments, a $1.5 million investment in a joint venture and capital expenditures of $1.5 million, which were offset by proceeds from maturities of short-term investments of $16.8 million and $6.4 million in sales of short-term investments. Capital expenditures in the nine months ended September 30, 2014 primarily consisted of manufacturing equipment.

Net cash provided by financing activities for the nine months ended September 30, 2015 was primarily the result of an underwritten public offering of an aggregate of 2,645,000 shares of common stock at a price per share of $50.00 resulting in net proceeds of $124.1 million. Stock option exercises and issuances of common stock resulted in net proceeds of $1.4 million.

Net cash provided by financing activities for the nine months ended September 30, 2014 was primarily the result of an underwritten public offering of an aggregate of 5,518,630 shares of common stock at a price per share of $10.00 resulting in net proceeds of $51.7 million.

We may need substantial additional funds to support our planned operations and commercialization strategy. We expect our existing cash, cash equivalents and short-term investments of $141.7 million at September 30, 2015 will enable us to fund our current operating plan at least into 2017. We have based this estimate on assumptions that may prove to be wrong, and we could use our available capital resources sooner than we currently expect. Because of the numerous risks and uncertainties associated with the development and commercialization of our treatments, and the extent to which we may enter into collaborations with third parties for development and commercialization of our treatments, we are unable to estimate the amounts of increased capital outlays and operating expenses associated with completing the development of our current treatments in development. Our future capital requirements will depend on many factors, including:


•	our success in expanding to new partner clinics in other major regions of the world, transitioning partner clinics to commercial centers and significantly increasing the number of patients receiving the AUGMENT treatment;


•	our success in optimizing and introducing the OvaPrime treatment to international IVF clinics;


•	the costs associated with the expansion of foreign operations and building out our international commercial infrastructure, including establishing and staffing an international headquarters and other international subsidiaries;


•	the costs associated with establishing a domestic and international sales, marketing, manufacturing and distribution infrastructure to commercialize the AUGMENT treatment and any potential fertility treatment we successfully develop;


•	the pricing of the AUGMENT treatment and resulting revenues, as well as any future revenues we receive from our potential fertility treatments;


•	the costs of continuing the optimization of the OvaTure treatment and our success in defining a development pathway;


•	the costs of any clinical trials of potential fertility treatments;


•	the costs involved in collaborating with Intrexon through the OvaXon joint venture to develop significant improvements in human and animal health;

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•	any applicable regulatory process in the United States and abroad, including the premarketing and marketing approval requirements, to which any of our potential fertility treatments may be subject;


•	any regulatory or institutional review board review of our potential fertility treatments that are subject to such review;


•	preparing, filing and prosecuting patent applications, maintaining and enforcing our intellectual property rights and defending intellectual property-related claims;


•	establishing collaborations and partnerships on favorable terms, if at all; and


•	developing, acquiring or in-licensing other potential fertility treatments and technologies.

Until such time, if ever, as we can generate sufficient revenues from the AUGMENT treatment or our potential fertility treatments to become profitable, we expect to finance our cash needs through a combination of equity offerings, debt financings, collaborations, strategic alliances and licensing arrangements. We do not have any committed external source of funds. In addition, we may elect to raise additional funds even before we need them if the conditions for raising capital are favorable. To the extent that we raise additional capital through the sale of equity or convertible debt securities, the ownership interest of our stockholders will be diluted, and the terms of these securities may include liquidation or other preferences that adversely affect the rights of common stockholders. Debt financing, if available, may involve agreements that include covenants limiting or restricting our ability to take specific actions, such as incurring additional debt, making capital expenditures or declaring dividends. If we raise additional funds through collaborations, strategic alliances or licensing arrangements with third parties, we may have to relinquish valuable rights to our technologies, future revenue streams, research programs or treatments or grant licenses on terms that may not be favorable to us. If we are unable to raise additional funds through equity or debt financings when needed, we may be required to delay, limit, reduce or terminate our fertility treatment development or future commercialization efforts or grant rights to develop and market treatments that we would otherwise prefer to develop and market ourselves.

Off-Balance Sheet Arrangements

We did not have during the periods presented, and we do not currently have, any off-balance sheet arrangements, as defined under SEC rules.

Contractual Obligations

There have been no material changes to our contractual obligations set forth under the heading “Management’s Discussion and Analysis of Financial Condition and Results of Operations — Contractual Obligations” in our Annual Report on Form 10-K for the year ended December 31, 2014, except for commitments resulting from our lease agreement as follows:

In May 2015, we entered into a lease agreement for approximately 25,200 square feet of office and laboratory space in a building in Waltham, MA. The term of the lease commenced on June 1, 2015 and extends through November 2020, with an optional additional five year term extension. Future non-cancelable minimum annual lease payments under the lease are expected to be approximately $0.1 million remaining in 2015, $0.9 million in 2016 and 2017, $1.0 million in each of 2018 and 2019, and $0.9 million in 2020. We have provided a security deposit in the form of a letter of credit in the amount of $0.4 million. The letter of credit is cash collateralized, which has been recorded as long-term restricted cash on the condensed consolidated balance sheet.

As a result, we have terminated one of our two existing leases in Cambridge, MA and expect to terminate the remaining lease in the fourth quarter of 2015.

Recently Adopted Accounting Standards

There are no recently issued accounting standards that have a material impact on us for the periods presented.

Item 3. Quantitative and Qualitative Disclosures About Market Risk

Our interest income is sensitive to changes in the general level of U.S. interest rates, particularly since a significant portion of our investments are in money market funds and corporate obligations. We do not enter into investments for trading or speculative purposes. We maintain our cash, cash equivalents and short-term investments with a high quality, accredited

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financial institution. Our marketable securities are subject to interest rate risk and will fall in value if market interest rates increase.

A hypothetical 100 basis point increase in interest rates would result in an approximately $0.6 million decrease in the fair value of our investments as of September 30, 2015, as compared to an approximately $0.2 million decrease as of December 31, 2014. We have the ability to hold our fixed income investments until maturity and, therefore, we do not expect our operating results or cash flows to be affected to any significant degree by the effect of a change in market interest rates on our investments.

Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures. Our management, with the participation of our principal executive officer and principal financial officer, evaluated the effectiveness of our disclosure controls and procedures as of September 30, 2015. The term “disclosure controls and procedures,” as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, means controls and other procedures of a company that are designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by a company in the reports that it files or submits under the Exchange Act is accumulated and communicated to the company’s management, including its principal executive and principal financial officers, as appropriate to allow timely decisions regarding required disclosure. Management recognizes that any controls and procedures, no matter how well designed and operated, can provide only reasonable assurance of achieving their objectives and management necessarily applies its judgment in evaluating the cost-benefit relationship of possible controls and procedures. Based on the evaluation of our disclosure controls and procedures as of September 30, 2015, our principal executive officer and principal financial officer concluded that, as of such date, our disclosure controls and procedures were effective at the reasonable assurance level.

Changes in Internal Controls. No change in our internal control over financial reporting occurred during the fiscal quarter ended September 30, 2015 that has materially affected, or is reasonably likely to materially affect, our internal control over financial reporting.

Part II. Other Information

Item 1. Legal Proceedings

On September 16, 2013, a purported shareholder class action, styled Meriam Ratner v. OvaScience, Inc., et al., was filed in the United States District Court for the District of Massachusetts, naming us and certain of our officers as defendants. The lawsuit alleges that we made material misrepresentations and/or omissions of material fact relating to the qualification of AUGMENT as a 361 HCT/P in our public disclosures during the period from February 25, 2013 through September 10, 2013, in violation of Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, and Rule 10b-5 promulgated thereunder. On February 2, 2014, we and certain of our officers, as defendants, filed a motion to dismiss with the District Court. On February 3, 2014, plaintiff Meriam Ratner voluntarily dismissed the suit without prejudice.

On June 6, 2014, this purported shareholder class action was re-filed by the plaintiff in the United States District Court for the District of Massachusetts, naming us and certain of our officers as defendants. The lawsuit includes the same allegations as were included in the action filed on September 16, 2013. The plaintiff filed an amended complaint on October 31, 2014. As amended, the complaint seeks certification of a class of purchasers of our stock during the period February 25, 2013 through September 10, 2013. The plaintiff seeks unspecified monetary damages on behalf of the putative class and an award of costs and expenses, including attorney’s fees. On December 16, 2014, we moved to dismiss the complaint. On September 28, 2015 the dismissal was granted by the court as matter of law and with prejudice.

On October 9, 2015, a purported class action lawsuit was filed in the Suffolk County Superior Court in the Commonwealth of Massachusetts against us, several of our officers and directors and certain of the underwriters from our January 2015 follow-on public offering of our common stock. The plaintiffs purport to represent those persons who purchased shares of our common stock pursuant or traceable to our January 2015 follow-on public offering. The plaintiffs allege, among other things, that the defendants made false and misleading statements and failed to disclose material information in the Company’s January 2015 Registration Statement and incorporated offering materials. Plaintiffs allege violations of Sections 11, 12 and 15 of the Securities Act of 1933, as amended, and seek, among other relief, unspecified compensatory damages, rescission, pre-and post-judgment interest and fees, costs and disbursements.

Table of Contents

We believe that the complaint is without merit and intend to defend against the litigation. There can be no assurance, however, that we will be successful. A resolution of this lawsuit adverse to the Company or the other defendants could have a material effect on our consolidated financial position and results of operations in the period in which the lawsuit is resolved. At present, we are unable to estimate potential losses, if any, related to the lawsuit.

We are not party to any other litigation in any court and management is not aware of any contemplated proceeding by any governmental authority against the Company.

Item 1A. Risk Factors

In addition to the other information set forth in this report, you should carefully consider the factors discussed in Part I, Item 1A. “Risk Factors” in our Annual Report on Form 10-K for the year ended December 31, 2014, which could materially affect our business, financial condition, or results of operations. Other than the addition of the following risk factor, there have been no material changes in or additions to the risk factors included in our Annual Report on Form 10-K for the year ended December 31, 2014.

We are currently subject to a securities class action lawsuit, the unfavorable outcome of which may have a material adverse effect on our financial condition, results of operations and cash flows.

In October 2015, a purported class action lawsuit was filed against us, certain of our executive officers, the members of our board of directors and certain of the underwriters from our January 2015 follow-on public offering of our common stock by investors alleging violations of the Securities Act of 1933, as amended. While we believe we have substantial legal and factual defenses to these claims in these lawsuits and we will vigorously defend the lawsuits, the outcome of litigation is difficult to predict and quantify, and the defense against such claims or actions can be costly and divert management resources. In connection with this lawsuit, we could incur substantial costs and such costs and any related settlements or judgments may not be covered by insurance.

Item 6. Exhibits

The exhibits filed as part of this Quarterly Report on Form 10-Q are set forth in the Exhibit Index and such Exhibit Index is incorporated herein by reference.

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Signatures

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.



	OVASCIENCE, INC.

	By:	/s/ Michelle Dipp, M.D., Ph.D.
		Name:	Michelle Dipp, M.D., Ph.D.
Date: November 5, 2015		Title:	Chief Executive Officer (Principal Executive Officer)


	By:	/s/ Jeffrey Young
		Name:	Jeffrey Young
Date: November 5, 2015		Title:	Chief Financial Officer (Principal Accounting and Financial Officer)

Table of Contents

Exhibit Index



Exhibit			Description
31.1			Certification of Principal Executive Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 by Principal Executive Officer.

31.2			Certification of Principal Financial Officer pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 by Principal Financial Officer.

32.1			Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, by Principal Executive Officer.

32.2			Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, by Principal Financial Officer.

101.INS			XBRL Instance Document

101.SCH			XBRL Taxonomy Extension Schema Document

101.CAL			XBRL Taxonomy Extension Calculation Linkbase Document

101.DEF			XBRL Taxonomy Extension Definition Linkbase Document

101.LAB			XBRL Taxonomy Extension Label Linkbase Document

101.PRE			XBRL Taxonomy Presentation Linkbase Document

Stock-based compensation - Founders' stock and stock options (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				9 Months Ended		12 Months Ended
	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014	Dec. 31, 2014
Additional disclosures
Stock-based compensation expense, reversed	$ 900
Founder
Shares
Unvested at the beginning of the period (in shares)	0	164,506	329,021		329,021
Granted (in shares)	0	0	0
Vested (in shares)	0	(164,506)	(164,515)
Unvested at the end of the period (in shares)	0	0	164,506		0		329,021
Stock options
Shares
Outstanding at the beginning of the period (in shares)			3,628,628		3,628,628
Granted (in shares)	284,500			284,000	1,710,100	1,451,598
Exercised (in shares)					(199,305)
Forfeited (in shares)					(405,301)
Outstanding at the end of the period (in shares)	4,734,122				4,734,122		3,628,628
Exercisable at the end of the period (in shares)	1,164,333				1,164,333
Vested and expected to vest at the end of the period (in shares)	3,942,778				3,942,778
Weighted average exercise price per share
Outstanding at the beginning of the period (in dollars per share)			$ 16.01		$ 16.01
Granted (in dollars per share)	$ 16.58			$ 15.67	34.38	$ 10.34
Exercised (in dollars per share)					8.04
Forfeited (in dollars per share)					30.05
Outstanding at the end of period (in dollars per share)	21.78				21.78		$ 16.01
Exercisable at the end of the period (in dollars per share)	10.49				10.49
Vested and expected to vest at the end of the period (in dollars per share)	$ 21.19				$ 21.19
Weighted Average Remaining contractual Term (years)
Outstanding at the beginning of the period					8 years 9 months 18 days		9 years 1 month 10 days
Outstanding at the end of the period					8 years 9 months 18 days		9 years 1 month 10 days
Exercisable at the end of the period					7 years 10 months 13 days
Vested and expected to vest at the end of the period					8 years 9 months
Aggregate intrinsic value
Outstanding at the beginning of the period			$ 102,355		$ 102,355
Outstanding at the end of period	$ 1,239				1,239		$ 102,355
Exercisable at the end of period	1,050				1,050
Vested and expected to vest at the end of the period	$ 1,199				$ 1,199
Assumptions used to estimate fair value of each stock-based option award on the grant date using the Black-Scholes option pricing model
Dividend yield	0.00%			0.00%	0.00%	0.00%
Additional disclosures
Total intrinsic value of options exercised	$ 100			$ 200	$ 6,600	$ 1,800
Total unrecognized compensation cost, net of estimated forfeitures, related to unvested stock options and restricted stock units	$ 40,000				$ 40,000
Weighted average period for recognition of compensation cost related to unvested stock awards					3 years 35 days
Weighted average grant date fair value (in dollars per share)	$ 10.71			$ 11.42	$ 21.79	$ 7.27
Stock options \| Minimum
Assumptions used to estimate fair value of each stock-based option award on the grant date using the Black-Scholes option pricing model
Risk-free interest rate					1.60%	1.60%
Volatility					72.00%	76.00%
Expected term (years)					5 years 3 months 18 days	5 years 3 months 18 days
Stock options \| Maximum
Assumptions used to estimate fair value of each stock-based option award on the grant date using the Black-Scholes option pricing model
Risk-free interest rate	1.70%			2.10%	2.30%	2.10%
Volatility	72.00%			84.00%	75.00%	84.00%
Expected term (years)	6 years 1 month 6 days			6 years 1 month 6 days	9 years 10 months 24 days	6 years 1 month 6 days

Common stock (Details) - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended		9 Months Ended
	Jan. 31, 2015	Mar. 31, 2014	Sep. 30, 2015	Sep. 30, 2014
Equity [Abstract]
Common stock issued (in shares)	2,645,000	5,518,630
Common stock issue price (in dollars per share)	$ 50	$ 10.00
Shares issued upon full exercise of options granted to underwriters (in shares)	345,000
Net proceeds from secondary public offering	$ 124,100	$ 51,700	$ 124,063	$ 51,554
Number of shares represents partial exercise of overallotment option granted to underwriters (in shares)		518,630

Stock-based compensation - Restricted stock units (Details) - Restricted stock units $ / shares in Units, $ in Thousands			1 Months Ended	3 Months Ended		9 Months Ended
	Dec. 09, 2014 tranche $ / shares shares	Dec. 05, 2012 tranche $ / shares shares	Dec. 31, 2012	Sep. 30, 2015 USD ($)	Sep. 30, 2014 USD ($)	Sep. 30, 2015 USD ($) shares	Sep. 30, 2014 USD ($)
Additional disclosures
Total unrecognized compensation cost, net of estimated forfeitures, related to unvested stock options and restricted stock units \| $				$ 700		$ 700
Weighted average period for recognition of compensation cost related to unvested stock awards						1 year 2 months 12 days
CEO \| December 9, 2014 Award
Stock-based compensation
Expense recorded at end of period \| $				145	$ 0	$ 498	$ 0
Additional disclosures
Minimum percentage required to satisfy a performance criteria	150.00%
Granted (in dollars per share) \| $ / shares	$ 43.47
CEO \| December 5, 2012 Award
Stock-based compensation
Expense recorded at end of period \| $				$ 0	191	$ 0	553
Additional disclosures
Minimum percentage required to satisfy a performance criteria				100.00%		100.00%
Service-based \| CEO
Additional disclosures
Vesting period	24 months		24 months
Service-based \| CEO \| December 9, 2014 Award
Stock-based compensation
Number of RSUs Granted	30,902
Grant Date Fair Value \| $ / shares	$ 32.36
Vested (in shares)	11,588
Expense recorded at end of period \| $				$ 123	0	$ 363	0
Service-based \| CEO \| December 5, 2012 Award
Stock-based compensation
Number of RSUs Granted		128,205
Grant Date Fair Value \| $ / shares		$ 7.80
Vested (in shares)						128,205
Expense recorded at end of period \| $				0	122	$ 0	361
Performance-based - Year 1 \| CEO \| December 9, 2014 Award
Stock-based compensation
Number of RSUs Granted	11,588
Grant Date Fair Value \| $ / shares	$ 43.47
Performance-based - Year 1 \| CEO \| December 5, 2012 Award
Stock-based compensation
Number of RSUs Granted		32,052
Grant Date Fair Value \| $ / shares		$ 10.00
Vested (in shares)						19,230
Performance-based - Year 2 \| CEO \| December 9, 2014 Award
Stock-based compensation
Number of RSUs Granted	11,588
Grant Date Fair Value \| $ / shares	$ 0.00
Performance-based - Year 2 \| CEO \| December 5, 2012 Award
Stock-based compensation
Number of RSUs Granted		32,051
Grant Date Fair Value \| $ / shares		$ 8.75
Vested (in shares)						32,051
Performance based restricted stock units \| CEO
Additional disclosures
Number of tranches \| tranche	2	2
Vesting period	1 year		1 year
Performance based restricted stock units \| CEO \| December 9, 2014 Award
Stock-based compensation
Expense recorded at end of period \| $				22	0	$ 135	0
Performance based restricted stock units \| CEO \| December 5, 2012 Award
Stock-based compensation
Expense recorded at end of period \| $				$ 0	$ 69	$ 0	$ 192

Commitments and Contingencies (Details) $ in Millions	1 Months Ended
Commitments and Contingencies (Details) $ in Millions	May. 31, 2015 USD ($) ft² lease	Sep. 30, 2015 USD ($)
Commitments and Contingencies Disclosure [Abstract]
Square footage of office and laboratory space \| ft²	25,200
Optional additional extension of lease	5 years
Future minimum payments due, remainder of fiscal year		$ 0.1
Future minimum payments, due in two years		0.9
Future minimum payments, due in three years		0.9
Future minimum payments, due in four years		1.0
Future minimum payments, due in five years		1.0
Future minimum payments, due thereafter		$ 0.9
Security deposit	$ 0.4
Improvement allowance	$ 1.2
Number of terminated leases \| lease	1
Number of leases in Cambridge, MA \| lease	2

OvaXon joint venture	9 Months Ended
OvaXon joint venture	Sep. 30, 2015
Equity Method Investments and Joint Ventures [Abstract]
OvaXon joint venture	OvaXon joint venture In December 2013, we entered into a joint venture with Intrexon Corporation (“Intrexon”) to leverage Intrexon’s synthetic biology technology platform and OvaScience’s technology relating to EggPC cells to focus on developing significant improvements in human and animal health. We and Intrexon formed OvaXon, LLC (“OvaXon”) to conduct the joint venture. Each party contributed $1.5 million of cash to OvaXon, each has a 50% equity interest and research and development costs and profits will be split accordingly. Each party will also have 50% control over OvaXon and any disputes between us and Intrexon will be resolved through arbitration, if necessary. We have recorded losses from equity method investments related to OvaXon of $0.3 million and $1.2 million for the three and nine months ended September 30, 2015, respectively. We have recorded losses from equity method investments related to OvaXon of $0.5 million and $0.9 million for the three and nine months ended September 30, 2014, respectively. Each party contributed an additional $1.5 million during the nine months ended September 30, 2015. We consider OvaXon a variable interest entity. OvaXon does not have a primary beneficiary as both we and Intrexon have equal ability to direct the activities of OvaXon through membership in a Joint Steering Committee and an Intellectual Property Committee and 50% voting rights. OvaXon has been accounted for under the equity method and is not consolidated. This analysis and conclusion will be updated annually to reflect any changes in ownership or control over OvaXon.



Date:	November 5, 2015

		/s/ Michelle Dipp, M.D., Ph.D.
		Michelle Dipp, M.D., Ph.D.
		Chief Executive Officer
		(Principal executive officer)

Cash, cash equivalents and short-term investments - Summary (Details) - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	$ 141,744	$ 60,257
Gross Unrealized Gains	14	2
Gross Unrealized Losses	(86)	(28)
Fair Value	141,672	60,231
Cash and money market funds
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	50,842	6,414
Gross Unrealized Gains	0	0
Gross Unrealized Losses	0	0
Fair Value	50,842	6,414
Corporate debt securities due in one year or less
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	59,695	53,843
Gross Unrealized Gains	7	2
Gross Unrealized Losses	(50)	(28)
Fair Value	59,652	53,817
Corporate debt securities, due in two years or less
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	31,207
Gross Unrealized Gains	7
Gross Unrealized Losses	(36)
Fair Value	31,178
Cash and cash equivalents
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	50,842	6,414
Gross Unrealized Gains	0	0
Gross Unrealized Losses	0	0
Fair Value	50,842	6,414
Short-term investments
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	90,902	53,843
Gross Unrealized Gains	14	2
Gross Unrealized Losses	(86)	(28)
Fair Value	$ 90,830	$ 53,817

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014
Current assets:
Cash and cash equivalents	$ 50,842	$ 6,414
Short-term investments	90,830	53,817
Prepaid expenses and other current assets	3,541	1,647
Restricted cash	109	0
Total current assets	145,322	61,878
Property and equipment, net	6,717	3,367
Investment in joint venture	241	0
Restricted cash	527	197
Other long-term assets	0	130
Total assets	152,807	65,572
Current liabilities:
Accounts payable	4,156	2,520
Accrued expenses and other current liabilities	5,707	7,654
Total current liabilities	9,863	10,174
Other non-current liabilities	358	73
Total liabilities	10,221	10,247
Stockholders’ equity:
Preferred stock, $0.001 par value; 5,000,000 shares authorized, no shares issued and outstanding	0	0
Common stock, $0.001 par value; 100,000,000 shares authorized; 27,276,410 and 24,413,666 shares issued at September 30, 2015 and December 31, 2014, respectively; 27,276,410 and 24,084,637 shares outstanding at September 30, 2015 and December 31, 2014, respectively	27	24
Additional paid-in capital	289,947	150,025
Accumulated other comprehensive loss	(72)	(26)
Accumulated deficit	(147,316)	(94,698)
Total stockholders’ equity	142,586	55,325
Total liabilities and stockholders’ equity	$ 152,807	$ 65,572

Organization and basis of presentation	9 Months Ended
Organization and basis of presentation	Sep. 30, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and basis of presentation	Organization and basis of presentation OvaScience, Inc., incorporated on April 5, 2011 as a Delaware corporation, is a global fertility company developing proprietary potential treatments for female infertility based on scientific discoveries about the existence of egg precursor, or EggPC^SM, cells. As used in these condensed consolidated financial statements, the terms “OvaScience,” “the Company,” “we,” “us,” and “our” refer to the business of OvaScience, Inc. and its wholly owned subsidiaries. Our operations to date have been limited to organizing and staffing our company, business planning, raising capital, acquiring and developing our technology, identifying potential fertility treatments, developing the AUGMENT^SM treatment, launching the AUGMENT treatment in select international in vitro fertilization (IVF) clinics, researching and developing the OvaPrime^SM treatment and the OvaTure^SM treatment, and determining the regulatory and development path for our fertility treatments. We have commenced our planned principal operations but have not generated any significant revenues to date. We are subject to a number of risks similar to other life science companies, including, but not limited to, the need to obtain adequate additional funding, possible failure to provide our treatments to IVF clinics to gain clinical experience in select countries outside of the United States, the need to obtain marketing approval for certain of our treatments, competitors developing new technological innovations, the need to successfully commercialize and gain market acceptance of our treatments and protection of proprietary technology. If we do not successfully commercialize our treatments, we will be unable to generate treatment revenue or achieve profitability. As of September 30, 2015 we had an accumulated deficit of approximately $147.3 million. Liquidity We have incurred annual net operating losses in each year since our inception. We have generated limited treatment revenues related to our primary business purpose and have financed our operations primarily through private placements of our preferred stock and public sales of our common stock. We have launched one fertility treatment, the AUGMENT treatment, in select international IVF clinics and have two potential treatments in development. We have devoted substantially all of our financial resources and efforts to the launch of the AUGMENT treatment, raising capital, and research and development. We expect to continue to incur significant expenses and operating losses for at least the next several years.

Basis of presentation and significant accounting policies (Details) - shares shares in Thousands	9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014
Net loss per share
Amount excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in shares)	4,765	3,464
Outstanding stock options and restricted stock units
Net loss per share
Amount excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in shares)	4,765	2,970
Unvested Founders’ stock
Net loss per share
Amount excluded from the calculation of diluted net loss per share, prior to the use of the treasury stock method, due to their anti-dilutive effect (in shares)	0	494

Fair value (Details) - Fair value measurements on a recurring basis - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014
Assets:
Total	$ 141,672	$ 60,231
Level 1
Assets:
Total	50,842	6,414
Level 2
Assets:
Total	90,830	53,817
Cash and money market funds
Assets:
Total	50,842	6,414
Cash and money market funds \| Level 1
Assets:
Total	50,842	6,414
Corporate debt securities (including commercial paper)
Assets:
Total	90,830	53,817
Corporate debt securities (including commercial paper) \| Level 2
Assets:
Total	$ 90,830	$ 53,817

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Sep. 30, 2015	Dec. 31, 2014
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	27,276,410	24,413,666
Common stock, shares outstanding	27,276,410	24,084,637

Document and Entity Information - shares	9 Months Ended
Document and Entity Information - shares	Sep. 30, 2015	Nov. 03, 2015
Document and Entity Information
Entity Registrant Name	OvaScience, Inc.
Entity Central Index Key	0001544227
Document Type	10-Q
Document Period End Date	Sep. 30, 2015
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Current Reporting Status	Yes
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		27,278,284
Document Fiscal Year Focus	2015
Document Fiscal Period Focus	Q3

Common stock	9 Months Ended
Common stock	Sep. 30, 2015
Equity [Abstract]
Common stock	Common stock In January 2015, we issued and sold in an underwritten public offering an aggregate of 2,645,000 shares of our common stock at $50 per share, which included 345,000 shares that represented the full exercise of an option to purchase additional shares granted to the underwriters in connection with the offering. The shares included in this offering were registered under the Securities Act of 1933, as amended, or the Securities Act, pursuant to a registration statement on Form S-3 (File No. 333-200040) that the Securities and Exchange Commission declared effective on November 21, 2014. The offering resulted in $124.1 million of net proceeds, after deducting underwriting discounts and commissions and other offering expenses payable by us. In March 2014, we issued and sold in a public offering an aggregate of 5,518,630 shares of our common stock at $10.00 per share, which included 518,630 shares that represented the partial exercise of an overallotment option granted to the underwriters in connection with the offering. The shares included in this offering were registered under the Securities Act of 1933, as amended, pursuant to a registration statement Form S-3 (File No. 333-190939) that the Securities and Exchange Commission declared effective on September 10, 2013. The offering resulted in $51.7 million of net proceeds, after deducting underwriting discounts and commissions and other offering expenses payable by us.

OvaXon joint venture (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended
OvaXon joint venture (Details) - USD ($) $ in Thousands	Dec. 31, 2013	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014
OvaXon joint venture
Amount contributed	$ 1,500
Equity interest	50.00%
Percentage of ownership control with disputes resolved through arbitration	50.00%
Loss from equity method investment		$ (316)	$ (523)	$ (1,176)	$ (915)
Additional contribution in joint venture				$ 1,500	$ 1,500
Voting rights				50.00%
Intrexon
OvaXon joint venture
Amount contributed	$ 1,500
Equity interest	50.00%
Percentage of ownership control with disputes resolved through arbitration	50.00%

Basis of presentation and significant accounting policies (Policies)	9 Months Ended
	Sep. 30, 2015
Accounting Policies [Abstract]
Principles of consolidation	Principles of consolidation These condensed consolidated financial statements include the accounts of OvaScience and the accounts of our wholly-owned subsidiaries. All intercompany transactions have been eliminated in consolidation.
Use of estimates	Use of estimates These condensed consolidated financial statements are presented in conformity with U.S. generally accepted accounting principles, which require management to make estimates and assumptions that affect the amounts reported in the condensed consolidated financial statements and accompanying notes. Actual results could differ from such estimates.
Selling, general and administrative costs	Selling, general and administrative costs We expense selling, general and administrative costs as incurred. Selling, general and administrative costs consist of ongoing costs to run our daily operations and internal costs to support the international launch of the AUGMENT^SM treatment.
Net loss per share	Net loss per share Basic and diluted net loss per common share is calculated by dividing net loss by the weighted average number of shares outstanding during the period. Potentially dilutive shares, including outstanding stock options and unvested restricted stock, are only included in the calculation of diluted net loss per share when their effect is dilutive.

Commitments and Contingencies	9 Months Ended
Commitments and Contingencies	Sep. 30, 2015
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies In May 2015, we entered into a lease agreement for approximately 25,200 square feet of office and laboratory space in a building in Waltham, MA. The term of the lease commenced on June 1, 2015 and extends through November 2020, with an optional additional five year term extension. Future non-cancelable minimum annual lease payments under the lease are expected to be approximately $0.1 million remaining in 2015, $0.9 million in 2016 and 2017, $1.0 million in each of 2018 and 2019, and $0.9 million in 2020. The price per square feet reflected in these amounts is significantly less compared to our existing leases in Cambridge, MA. We have provided a security deposit in the form of a letter of credit in the amount of $0.4 million. The letter of credit is cash collateralized, which has been recorded as long-term restricted cash on the condensed consolidated balance sheet. In connection with this lease, the landlord is providing a tenant improvement allowance of up to $1.2 million for the costs associated with the construction of tenant improvements for the leased facility. We will account for the allowance incurred as a lease incentive, which will be recorded as a reduction to rent expense over the lease term. As a result, we have terminated one of our two existing leases in Cambridge, MA and expect to terminate the remaining lease in the fourth quarter of 2015.

Organization and basis of presentation (Details) $ in Thousands	Sep. 30, 2015 USD ($) treatment	Dec. 31, 2014 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accumulated deficit \| $	$ (147,316)	$ (94,698)
Number of treatments	1
Potential treatments in development	2

Cash, cash equivalents and short-term investments - Narrative (Details) $ in Thousands	Sep. 30, 2015 USD ($) investment	Dec. 31, 2014 USD ($) investment
Schedule of Available-for-sale Securities [Line Items]
Debt securities in an unrealized position for less than 12 months \| investment	27	32
Aggregate fair value of securities in an unrealized loss position for less than 12 months	$ 54,800	$ 44,200
Number of securities that declined in market value \| investment	27
Securities held	$ 141,744	60,257
Debt securities
Schedule of Available-for-sale Securities [Line Items]
Securities held	$ 15,000	$ 7,500

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2015	Sep. 30, 2014
Cash flows from operating activities:
Net loss	$ (52,618)	$ (30,630)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	748	262
Amortization of premium on debt securities	792	638
Stock-based compensation expense	14,417	6,035
Net loss on equity method investment	1,176	915
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,894)	(798)
Accounts payable	(139)	1,893
Accrued expenses and other non-current liabilities	(1,449)	1,621
Net cash used in operating activities	(38,967)	(20,064)
Cash flows from investing activities:
Investment in joint venture	(1,500)	(1,500)
Purchases of property, plant and equipment	(2,323)	(1,469)
Maturities of short-term investments	41,104	16,820
Sales of short-term investments	3,117	6,418
Purchases of short-term investments	(82,072)	(57,603)
Increase in restricted cash	(439)	(109)
Net cash used in investing activities	(42,113)	(37,443)
Cash flows from financing activities:
Net proceeds from the issuance of common stock	124,063	51,554
Issuances of common stock under benefit plans, net of withholding taxes paid	1,445	0
Net cash provided by financing activities	125,508	51,554
Net increase (decrease) in cash and cash equivalents	44,428	(5,953)
Cash and cash equivalents at beginning of period	6,414	18,078
Cash and cash equivalents at end of period	$ 50,842	$ 12,125

Property and equipment (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
Property and equipment (Details) - USD ($) $ in Thousands	Sep. 30, 2015	Sep. 30, 2014	Sep. 30, 2015	Sep. 30, 2014	Dec. 31, 2014
Property and equipment
Property and equipment, gross	$ 8,600		$ 8,600		$ 4,505
Less: accumulated depreciation	(1,883)		(1,883)		(1,138)
Property and equipment, net	6,717		6,717		3,367
Depreciation and amortization expense	300	$ 100	748	$ 262
Laboratory equipment
Property and equipment
Property and equipment, gross	6,033		6,033		4,093
Furniture
Property and equipment
Property and equipment, gross	451		451		207
Computer equipment
Property and equipment
Property and equipment, gross	189		189		7
Leasehold improvements
Property and equipment
Property and equipment, gross	$ 1,927		$ 1,927		$ 198