Income Taxes (Tables)

12 Months Ended

Dec. 31, 2014

Income Taxes

Schedule of reconciliation of income taxes computed using the U.S. federal statutory rate to that reflected in operations

	Year Ended December 31, 2014			Year Ended December 31, 2013			Year Ended December 31, 2012
Income tax benefit using U.S. federal statutory rate		34.00	%		34.00	%		34.00	%
State income taxes, net of federal benefit		5.28	%		5.28	%		5.42	%
Research and development tax credits		1.75	%		2.31	%		0.00	%
Permanent items		(0.55	)%		(1.09	)%		(2.78	)%
Foreign differential		(1.59	)%		—%			—%
Other adjustments (state)		(0.03	)%		—%			—%
Change in the valuation allowance		(38.86	)%		(40.50	)%		(36.64	)%
		—	%		—	%		—	%

Schedule of principal components of deferred tax assets

        The principal components of our deferred tax assets are as follows (in thousands):

	2014			2013
Deferred Tax Assets:
Net operating loss carryforwards		26,133			12,939
Tax credit carryforwards		1,689			823
Accrued Expenses		655			190
Stock based compensation		5,591			1,602
Intangibles		2,536			1,954
Other		305			160
Gross deferred tax assets		36,909			17,668
Valuation allowance		(36,909	)		(17,668	)
Net deferred tax assets		—			—