Exhibit 32.2

Certification

Pursuant to the requirement set forth in Section 906 of the Sarbanes-Oxley Act of 2002, Karen A. Schoenbaum hereby certifies as follows:

1. She is the duly appointed Chief Financial Officer of CU Bancorp, a California state chartered banking corporation (the “Bank”).

2. Based on her knowledge, the Company’s Quarterly Report on Form 10-Q for the period ended March 31, 2014, and to which this Certification is attached as Exhibit 32.2 (the “Periodic Report”), fully complies with the requirements of section 13(a) or section 15(d) of the Securities Exchange Act of 1934 and the information contained in the Periodic Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

IN WITNESS WHEREOF, the undersigned has set his hand hereto as of this 9th day of May 2014.

/s/    KAREN A. SCHOENBAUM        

Karen A. Schoenbaum

Executive Vice President and Chief Financial Officer