The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC Common Stock 00287Y109   308,852 2,072 SH   SOLE   308,852 0 0
ACADIA PHARMACEUTICALS INC Common Stock 004225108   340,797 16,353 SH   SOLE   340,797 0 0
ACTIVISION BLIZZARD INC Common Stock 00507V109   4,962,390 53,000 SH   SOLE   4,962,390 0 0
AGILENT TECHNOLOGIES INC Common Stock 00846U101   296,435 2,651 SH   SOLE   296,435 0 0
ALNYLAM PHARMACEUTICALS INC Common Stock 02043Q107   328,698 1,856 SH   SOLE   328,698 0 0
ARGENX SE - ADR ADR 04016X101   626,828 1,275 SH   SOLE   626,828 0 0
ASCENDIS PHARMA - ADR ADR 04351P101   215,840 2,305 SH   SOLE   215,840 0 0
ASTRAZENECA PLC-SPONS ADR ADR 046353108   663,453 9,797 SH   SOLE   663,453 0 0
BECTON DICKINSON AND CO Common Stock 075887109   357,547 1,383 SH   SOLE   357,547 0 0
BEIGENE LTD-ADR ADR 07725L102   751,857 4,180 SH   SOLE   751,857 0 0
BIOMARIN PHARMACEUTICAL INC Common Stock 09061G101   240,046 2,713 SH   SOLE   240,046 0 0
CENTENE CORP Common Stock 15135B101   275,107 3,994 SH   SOLE   275,107 0 0
CIGNA CORP Common Stock 125523100   244,018 853 SH   SOLE   244,018 0 0
DAIICHI SANKYO CO LTD Common Stock J11257102   19,897,676 4,846 SH   SOLE   19,897,676 0 0
DANAHER CORP Common Stock 235851102   701,627 2,828 SH   SOLE   701,627 0 0
ELEVANCE HEALTH INC Common Stock 036752103   519,456 1,193 SH   SOLE   519,456 0 0
ELI LILLY & CO Common Stock 532457108   1,260,107 2,346 SH   SOLE   1,260,107 0 0
GENMAB A/S Common Stock K3967W102   978,120 390 SH   SOLE   978,120 0 0
GRUPO FINANCIERO GALICIA-ADR ADR 399909100   159,210 12,200 SH   SOLE   159,210 0 0
HUMANA INC Common Stock 444859102   405,271 833 SH   SOLE   405,271 0 0
INCYTE CORP Common Stock 45337C102   719,641 12,457 SH   SOLE   719,641 0 0
INTUITIVE SURGICAL INC Common Stock 46120E602   629,300 2,153 SH   SOLE   629,300 0 0
ITAU UNIBANCO HLDNG-PREF ADR ADR 465562106   143,760 26,771 SH   SOLE   143,760 0 0
JACOBS SOLUTIONS INC Common Stock 46982L108   270,816 1,984 SH   SOLE   270,816 0 0
LITHIUM IONIC CORP Common Stock 53680V107   6,112,294 3,056,147 SH   SOLE   6,112,294 0 0
MARKET VECTORS GOLD MINERS ETP 92189F106   688,439 25,583 SH   SOLE   688,439 0 0
MERCADOLIBRE INC Common Stock 58733R102   18,940,859 14,939 SH   SOLE   18,940,859 0 0
MERCK & CO. INC. Common Stock 58933Y105   637,775 6,195 SH   SOLE   637,775 0 0
MOLINA HEALTHCARE INC Common Stock 60855R100   299,364 913 SH   SOLE   299,364 0 0
NU HOLDINGS LTD/CAYMAN ISL-A Common Stock G6683N103   11,394,006 1,571,587 SH   SOLE   11,394,006 0 0
OI SA-ADR ADR 670851500   978 575,000 SH   SOLE   978 0 0
OSISKO MINING INC Common Stock 688281104   4,920,000 2,000,000 SH   SOLE   4,920,000 0 0
PFIZER INC Common Stock 717081103   284,963 8,591 SH   SOLE   284,963 0 0
REGENERON PHARMACEUTICALS Common Stock 75886F107   674,004 819 SH   SOLE   674,004 0 0
SBERBANK PJSC - SPONSORED ADR ADR 80585Y308   7,248 160,000 SH   SOLE   7,248 0 0
SEAGEN INC Common Stock 81181C104   3,733,416 17,598 SH   SOLE   3,733,416 0 0
SHELL PLC-ADR ADR 780259305   255,911 3,975 SH   SOLE   255,911 0 0
SIGMA LITHIUM CORP Common Stock 826599102   17,991,548 554,610 SH   SOLE   17,991,548 0 0
SPINNOVA OYJ Common Stock X84439102   111,982 34,089 SH   SOLE   111,982 0 0
SPROTT PHYSICAL URANIUM TRUS Closed-End Fund 85210A104   9,272,000 400,000 SH   SOLE   9,272,000 0 0
STONECO LTD-A Common Stock G85158106   16,602,637 1,556,011 SH   SOLE   16,602,637 0 0
STRYKER CORP Common Stock 863667101   494,619 1,810 SH   SOLE   494,619 0 0
TELECOM ARGENTINA SA-SP ADR ADR 879273209   179,625 37,500 SH   SOLE   179,625 0 0
THERMO FISHER SCIENTIFIC INC Common Stock 883556102   951,093 1,879 SH   SOLE   951,093 0 0
UBS AG-REG Common Stock H42097107   264,322 10,723 SH   SOLE   264,322 0 0
UNITEDHEALTH GROUP INC Common Stock 91324P102   1,581,140 3,136 SH   SOLE   1,581,140 0 0
VERTEX PHARMACEUTICALS INC Common Stock 92532F100   520,567 1,497 SH   SOLE   520,567 0 0
VINCI PARTNERS INVESTMENTS-A Common Stock G9451V109   166,770 16,350 SH   SOLE   166,770 0 0
XP INC - CLASS A Common Stock G98239109   25,975,345 1,126,913 SH   SOLE   25,975,345 0 0
YPF S.A.-SPONSORED ADR ADR 984245100   187,425 15,300 SH   SOLE   187,425 0 0
HESS CORP Common Stock 42809H107   174,000 2,400 SH Put SOLE   174,000 0 0
SIGMA LITHIUM CORP Common Stock 826599102   340,000 2,000 SH Put SOLE   340,000 0 0
XP INC - CLASS A Common Stock G98239109   44,625 1,050 SH Put SOLE   44,625 0 0