Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in the following Registration Statements:           

1. Registration Statement (Form F-3 No. 333-236064) of Can-Fite Biopharma Ltd.,

2. Registration Statement (Form F-3 No. 333-276000) of Can-Fite Biopharma Ltd.,

3. Registration Statement (Form F-3 No. 333-274316) of Can-Fite Biopharma Ltd.,

4. Registration Statement (Form F-3 No. 333-262055) of Can-Fite Biopharma Ltd., and

5. Registration Statement (Form S-8 No. 333-271384) pertaining to the 2013 Global Incentive Option Scheme of Can-Fite Biopharma Ltd.

6. Registration Statement (Form S-8 No. 333-227753) pertaining to the 2003 Israeli Share Option Plan and 2013 Global Incentive Option Scheme of Can-Fite Biopharma Ltd.

of our report dated March 28, 2024, with respect to the consolidated financial statements of Can-Fite Biopharma Ltd. included in this Annual Report (Form 20-F) of Can-Fite Biopharma Ltd. for the year ended December 31, 2023.

Tel-Aviv, Israel
March 28, 2024 /s/ Kost Forer Gabbay & Kasierer
A Member of EY Global