Income Taxes (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Income Taxes [Line Items]
Income Tax Expense (Benefit)	$ 700	$ 700	$ 752
Operating Loss Carryforwards	$ 106,600,000
Operating Loss Carry forwards Expiration Date1	Approximately $25.7 million of the NOL will expire between 2023 and 2033 and $70.8 million of the NOL will expire 2034 through 2037. Pursuant to the Tax Cuts and Jobs Act of 2017, NOL's generated in 2018 and subsequent years have an unlimited carryforward therefore the 2018 NOL of $10.1 million can be carried forward indefinitely. The research and development credits will begin to expire in 2033 through 2038.
Tax Credit Carryforward, Amount	$ 2,300,000
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent	21.00%	34.00%	34.00%
Deferred Tax Assets, Valuation Allowance	$ 33,493,680	$ 30,813,270
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount	2,700,000	5,100,000
Operating Loss Carry forwards Limitations On Use Amount	1,100,000
Operating Loss Carry forwards Pre-ownership Change Amount	20,200,000
Operating Loss Forgive Pre-ownership Change Amount	5,500,000
Tax Credit Carryforward Pre-ownership Change Amount	1,200,000
Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount		$ 13,240,342	$ 0
Scenario, Plan [Member]
Income Taxes [Line Items]
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent	21.00%
U.S. Federal [Member]
Income Taxes [Line Items]
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent		34.00%
U.S. Federal [Member] | Research and Development Expense [Member]
Income Taxes [Line Items]
Tax Credit Carryforward, Description	expire in 2033 through 2038.
State And Local [Member]
Income Taxes [Line Items]
Operating Loss Carryforwards	$ 100,200,000
Operating Loss Carry forwards Expiration Date1	Approximately $194,000 of the Company's state NOL expires in 2019, $37.5 million expires between 2020 and 2029, and $62.4 million will expire in 2030 through 2033. The state research and development credits expire in 2023 through 2032.
State And Local [Member] | Research and Development Expense [Member]
Income Taxes [Line Items]
Tax Credit Carryforward, Amount	$ 1,100,000
Tax Credit Carryforward, Description	expire in 2023 through 2032.
Domestic Tax Authority [Member]
Income Taxes [Line Items]
Operating loss carry forwards non expire date	Pursuant to the Tax Cuts and Jobs Act of 2017, NOL’s generated in 2018 and subsequent years have an unlimited carryforward therefore the 2018 NOL of $10.1 million can be carried forward indefinitely.