The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y909 3,493 369 SH Call DFND 1 0 369 0
ABEONA THERAPEUTICS INC COM 00289Y107 187 12,998 SH   DFND 1 0 12,998 0
ACCELERON PHARMA INC COM 00434H908 215 55 SH Call DFND 1 0 55 0
ACCELERON PHARMA INC COM 00434H108 338 8,646 SH   DFND 1 0 8,646 0
ACCELERON PHARMA INC COM 00434H958 2,049 524 SH Put DFND 1 0 524 0
ACHAOGEN INC COM 004449904 923 713 SH Call DFND 1 0 713 0
ACHAOGEN INC COM 004449954 1,819 1,405 SH Put DFND 1 0 1,405 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 729 1,997,700 SH   DFND 1 0 1,997,700 0
ADOMANI INC COM COM 00726A100 995 843,407 SH   DFND 1 0 843,407 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U908 548 944 SH Call DFND 1 0 944 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 1,154 198,964 SH   DFND 1 0 198,964 0
AFFIMED INC COM N01045108 787 425,463 SH   DFND 1 0 425,463 0
AKEBIA THERAPEUTICS INC COM 00972D105 975 102,338 SH   DFND 1 0 102,338 0
ALEXION PHARMACEUTICALS INC COM 015351959 1,070 96 SH Put DFND 1 0 96 0
ALEXION PHARMACEUTICALS INC COM 015351909 6,610 593 SH Call DFND 1 0 593 0
ALKERMES PLC SHS G01767955 910 157 SH Put DFND 1 0 157 0
ALKERMES PLC SHS G01767905 3,918 676 SH Call DFND 1 0 676 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 1,370 11,500 SH   DFND 1 0 11,500 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 2,978 250 SH Put DFND 1 0 250 0
AMARIN CORP PLC ADR 023111206 61 20,300 SH   DFND 1 0 20,300 0
AMARIN CORP PLC ADR 023111956 334 1,109 SH Put DFND 1 0 1,109 0
AMARIN CORP PLC ADR 023111906 2,504 8,319 SH Call DFND 1 0 8,319 0
AMICUS THERAPEUTICS INC COM 03152W109 976 64,910 SH   DFND 1 0 64,910 0
AMICUS THERAPEUTICS INC COM 03152W959 1,504 1,000 SH Put DFND 1 0 1,000 0
AMICUS THERAPEUTICS INC COM 03152W909 1,512 1,005 SH Call DFND 1 0 1,005 0
AMPLIPHI BIOSCIENCES CORP COM 03211P301 907 831,961 SH   DFND 1 0 831,961 0
AMYRIS INC COM 03236M950 1,887 2,821 SH Put DFND 1 0 2,821 0
APPLIED DNA SCIENCES INC *W 03815U110 162 648,824 SH   DFND 1 0 648,824 0
APPLIED DNA SCIENCES INC COM 03815U201 654 454,381 SH   DFND 1 0 454,381 0
APRICUS BIOSCIENCES INC COM 03832V307 731 1,800,000 SH   DFND 1 0 1,800,000 0
AQUABOUNTY TECHNOLOGIES INC COM 03842K200 0 113 SH   DFND 1 0 113 0
ARCADIA BIOSCIENCES INC COM 039014204 3,611 150,376 SH   DFND 1 0 150,376 0
ASTRAZENECA PLC ADR 046353958 29,305 8,380 SH Put DFND 1 0 8,380 0
ASTRAZENECA PLC ADR 046353908 51,214 14,645 SH Call DFND 1 0 14,645 0
AURIS MEDICAL HOLDING AG COM H0381L104 549 342,989 SH   DFND 1 0 342,989 0
AVEO PHARMACEUTICALS INC COM 053588909 2,486 8,571 SH Call DFND 1 0 8,571 0
AXSOME THERAPEUTICS INC COM 05464T104 199 81,159 SH   DFND 1 0 81,159 0
BENITEC BIOPHARMA LTD *W 082053117 21 87,693 SH Call DFND 1 0 87,693 0
BIO PATH HOLDINGS INC COM 09057N102 170 85,013 SH   DFND 1 0 85,013 0
BIOAMBER INC COM 09072Q106 368 7,819,887 SH   DFND 1 0 7,819,887 0
BIOCEPT INC COM 09072V204 27 92,374 SH   DFND 1 0 92,374 0
BIOGEN INC COM 09062X903 821 30 SH Call DFND 1 0 30 0
BIOGEN INC COM 09062X953 48,928 2,071 SH Put DFND 1 0 2,071 0
BIOGEN INC COM 09062X103 50,081 182,898 SH   DFND 1 0 182,898 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 70 22,323 SH   DFND 1 0 22,323 0
BRISTOL MYERS SQUIBB COM 110122108 1,474 23,312 SH   DFND 1 0 23,312 0
BRISTOL MYERS SQUIBB COM 110122958 1,777 281 SH Put DFND 1 0 281 0
CAN FITE BIOPHARMA LTD ADR 13471N102 1,768 1,228,091 SH   DFND 1 0 1,228,091 0
CELLECT BIOTECHNOLOGY LTD ADS 15116C102 1,557 243,980 SH   DFND 1 0 243,980 0
CELSION CORP COM 15117N503 828 369,860 SH   DFND 1 0 369,860 0
CHECK-CAP LTD COM M2361E112 39 75,280 SH   DFND 1 0 75,280 0
CHF SOLUTIONS INC COM 12542Q508 504 180,498 SH   DFND 1 0 180,498 0
CITIUS PHARMACEUTICALS INC COM 17322U207 1,988 641,201 SH   DFND 1 0 641,201 0
CYTORI THERAPEUTICS INC COM 23283K121 14 520,858 SH Call DFND 1 0 520,858 0
DBV TECHNOLOGIES SA ADS 23306J901 595 258 SH Call DFND 1 0 258 0
EDAP TMS SA ADR 268311107 141 60,600 SH   DFND 1 0 60,600 0
EDAP TMS SA ADR 268311957 234 1,008 SH Put DFND 1 0 1,008 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 317 32,190 SH   DFND 1 0 32,190 0
ELEVEN BIOTHERAPEUTICS INC COM 286221106 1,287 1,226,117 SH   DFND 1 0 1,226,117 0
ESPERION THERAPEUTICS INC COM 29664W105 1,361 18,823 SH   DFND 1 0 18,823 0
ESPERION THERAPEUTICS INC COM 29664W905 3,891 538 SH Call DFND 1 0 538 0
ESPERION THERAPEUTICS INC COM 29664W955 43,781 6,053 SH Put DFND 1 0 6,053 0
EYENOVIA INC COM 30234E104 908 97,770 SH   DFND 1 0 97,770 0
FIBROGEN INC COM 31572Q908 522 113 SH Call DFND 1 0 113 0
FUELCELL ENERGY INC COM 35952H502 158 91,400 SH   DFND 1 0 91,400 0
FUELCELL ENERGY INC COM 35952H952 570 3,297 SH Put DFND 1 0 3,297 0
GALECTIN THERAPEUTICS INC COM 363225952 100 210 SH Put DFND 1 0 210 0
GALECTIN THERAPEUTICS INC COM 363225202 680 143,400 SH   DFND 1 0 143,400 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 3,661 758 SH Call DFND 1 0 758 0
GLYCOMIMETICS INC COM 38000Q102 838 51,603 SH   DFND 1 0 51,603 0
HALOZYME THERAPEUTICS INC COM 40637H109 2 102 SH   DFND 1 0 102 0
HELIOS &MATHESON ANALYTICS INC COM 42327L950 581 2,054 SH Put DFND 1 0 2,054 0
HELIOS &MATHESON ANALYTICS INC COM 42327L200 706 249,294 SH   DFND 1 0 249,294 0
IMMUNOCELLULAR THERAPEUTICS *W 452536121 7 225,187 SH Call DFND 1 0 225,187 0
IMMUNOGEN INC COM 45253H951 173 164 SH Put DFND 1 0 164 0
INCYTE CORP COM 45337C102 6,821 81,861 SH   DFND 1 0 81,861 0
INCYTE CORP COM 45337C902 9,500 1,140 SH Call DFND 1 0 1,140 0
INCYTE CORP COM 45337C952 10,791 1,295 SH Put DFND 1 0 1,295 0
INPIXON COM 45790J305 394 366,925 SH   DFND 1 0 366,925 0
INSMED INC COM 457669307 300 13,300 SH   DFND 1 0 13,300 0
INSMED INC COM 457669957 1,223 543 SH Put DFND 1 0 543 0
INSPIREMD INC *W 45779A127 18 911,373 SH   DFND 1 0 911,373 0
INSPIREMD INC *W 45779A135 30 1,998,417 SH   DFND 1 0 1,998,417 0
INSPIREMD INC COM 45779A804 254 243,794 SH   DFND 1 0 243,794 0
INTERPACE DIAGNOSTICS GROUP COM 46062X204 812 919,854 SH   DFND 1 0 919,854 0
ISHARES RUSSELL 2000 ETF 464287905 37,958 2,500 SH Call DFND 1 0 2,500 0
ISHARES RUSSELL 2000 ETF 464287955 43,651 2,875 SH Put DFND 1 0 2,875 0
MANNKIND CORP COM 56400P706 228 1,000 SH Call DFND 1 0 1,000 0
MANNKIND CORP COM 56400P706 460 201,908 SH   DFND 1 0 201,908 0
MANNKIND CORP COM 56400P906 735 3,224 SH Put DFND 1 0 3,224 0
MARINUS PHARMACEUTICALS INC COM 56854Q901 172 451 SH Call DFND 1 0 451 0
MEDIGUS LTD ADR 58471G201 30 23,606 SH   DFND 1 0 23,606 0
MERCK & CO INC COM 58933Y105 374 6,864 SH   DFND 1 0 6,864 0
MERCK & CO INC COM 58933Y955 654 120 SH Put DFND 1 0 120 0
MERCK & CO INC COM 58933Y905 13,563 2,490 SH Call DFND 1 0 2,490 0
MICROBOT MED INC COM 59503A105 843 1,249,400 SH   DFND 1 0 1,249,400 0
NANOVIBRONIX INC COM 63008J108 408 85,791 SH   DFND 1 0 85,791 0
NEKTAR THERAPEUTICS COM 640268958 2,975 280 SH Put DFND 1 0 280 0
NEKTAR THERAPEUTICS COM 640268108 6,251 58,831 SH   DFND 1 0 58,831 0
NEKTAR THERAPEUTICS COM 640268908 7,704 725 SH Call DFND 1 0 725 0
NEUROMETRIX INC COM 641255708 1,002 710,389 SH   DFND 1 0 710,389 0
NOVAN INC COM 66988N106 1,597 545,149 SH   DFND 1 0 545,149 0
ODONATE THERAPEUTICS INC COM 676079106 15,552 734,272 SH   DFND 1 0 734,272 0
ONCOBIOLOGICS INC COM 68235M105 1,876 2,108,249 SH   DFND 1 0 2,108,249 0
ONCONOVA THERAPEUTICS INC *W 68232V116 196 654,019 SH   DFND 1 0 654,019 0
ONCONOVA THERAPEUTICS INC COM 68232V306 334 399,580 SH   DFND 1 0 399,580 0
OPGEN INC COM 68373L109 875 521,076 SH   DFND 1 0 521,076 0
OVASCIENCE INC COM 69014Q101 1,185 1,461,525 SH   DFND 1 0 1,461,525 0
PAVMED INC COM 70387R106 1,490 908,817 SH   DFND 1 0 908,817 0
PLURISTEM THERAPEUTICS INC COM 72940R952 17 122 SH Put DFND 1 0 122 0
PLURISTEM THERAPEUTICS INC COM 72940R102 38 27,640 SH   DFND 1 0 27,640 0
PRECIPIO INC COM 74019L107 411 764,411 SH   DFND 1 0 764,411 0
PROQR THERAPEUTICS N V SHS N71542109 529 172,160 SH   DFND 1 0 172,160 0
PROTHENA CORPORATION PLC SHS G72800908 74 240 SH Call DFND 1 0 240 0
PROTHENA CORPORATION PLC SHS G72800108 899 24,500 SH   DFND 1 0 24,500 0
PROTHENA CORPORATION PLC SHS G72800958 1,336 431 SH Put DFND 1 0 431 0
PTC THERAPEUTICS INC COM 69366J900 84 1,475 SH Call DFND 1 0 1,475 0
PULMATRIX INC COM 74584P103 554 1,087,507 SH   DFND 1 0 1,087,507 0
ROSETTA GENOMICS LTD SHS M82183209 383 934,608 SH   DFND 1 0 934,608 0
RXI PHARMACEUTICALS CORP *W 74979C121 88 196,522 SH   DFND 1 0 196,522 0
SANGAMO THERAPEUTICS INC COM 800677906 435 229 SH Call DFND 1 0 229 0
SANGAMO THERAPEUTICS INC COM 800677106 2,701 142,136 SH   DFND 1 0 142,136 0
SANGAMO THERAPEUTICS INC COM 800677956 6,433 3,386 SH Put DFND 1 0 3,386 0
SAREPTA THERAPEUTICS INC COM 803607950 6,579 888 SH Put DFND 1 0 888 0
SAREPTA THERAPEUTICS INC COM 803607900 17,285 2,333 SH Call DFND 1 0 2,333 0
SELLAS LIFE SCIENCES GROUP INC COM 81642T900 4 1,518 SH Call DFND 1 0 1,518 0
SELLAS LIFE SCIENCES GROUP INC COM 81642T100 1,067 309,207 SH   DFND 1 0 309,207 0
SENESTECH INC COM 81720R109 405 794,740 SH   DFND 1 0 794,740 0
SIGMA LABS INC *W 826598112 142 375,718 SH   DFND 1 0 375,718 0
SOLENO THERAPEUTICS COM 834203200 1,661 917,835 SH   DFND 1 0 917,835 0
SOLID BIOSCIENCES INC COM 83422E105 188 25,000 SH   DFND 1 0 25,000 0
SONOMA PHARMACEUTICALS INC COM 83558L105 255 69,200 SH   DFND 1 0 69,200 0
SOPHIRIS BIO INC COM 83578Q909 58 290 SH Call DFND 1 0 290 0
SOPHIRIS BIO INC COM 83578Q959 147 729 SH Put DFND 1 0 729 0
SPARK THERAPEUTICS INC COM 84652J903 5,161 775 SH Call DFND 1 0 775 0
SPARK THERAPEUTICS INC COM 84652J953 6,759 1,015 SH Put DFND 1 0 1,015 0
SPDR S&P 500 TR 78462F103 11,710 44,500 SH   DFND 1 0 44,500 0
SPDR S&P 500 TR 78462F953 259,650 9,867 SH Put DFND 1 0 9,867 0
SPDR S&P BIOTECH S&P BIOTECH 78464A950 9,843 1,122 SH Put DFND 1 0 1,122 0
STRATA SKIN SCIENCES INC COM 86272A206 368 315,745 SH   DFND 1 0 315,745 0
SUNESIS PHARMACEUTICALS INC COM 867328900 380 1,396 SH Call DFND 1 0 1,396 0
SUPERCONDUCTOR TECHNOLOGIES COM 867931503 693 735,880 SH   DFND 1 0 735,880 0
SYNERGY PHARMACEUTICALS INC COM 871639908 907 4,954 SH Call DFND 1 0 4,954 0
TRANSENTERIX INC COM 89366M951 124 728 SH Put DFND 1 0 728 0
TRANSENTERIX INC COM 89366M201 436 256,715 SH   DFND 1 0 256,715 0
UNUM THERAPEUTICS INC COM 903214104 2,917 262,595 SH   DFND 1 0 262,595 0
VERSARTIS INC COM 92529L902 3 200 SH Call DFND 1 0 200 0
VERSARTIS INC COM 92529L102 1,159 702,364 SH   DFND 1 0 702,364 0
VERTEX PHARMACEUTICALS INC COM 92532F900 861 1,315 SH Call DFND 1 0 1,315 0
VICAL INC. COM 925602203 87 59,832 SH   DFND 1 0 59,832 0
VISTAGEN THERAPEUTICS INC COM 92840H202 133 143,486 SH   DFND 1 0 143,486 0
VOLITIONRX LTD COM 928661107 32 13,167 SH   DFND 1 0 13,167 0
XENON PHARMACEUTICALS INC COM 98420N105 328 67,000 SH   DFND 1 0 67,000 0
ZOGENIX INC COM 98978L954 2,751 687 SH Put DFND 1 0 687 0
ZOGENIX INC COM 98978L904 16,256 4,059 SH Call DFND 1 0 4,059 0
ZOSANO PHARMA CORO COM 98979H202 1,178 233,779 SH   DFND 1 0 233,779 0