The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 2,665 27,559 SH   DFND 1 0 27,559 0
ABBVIE INC COM 00287Y909 242 25 SH Call DFND 1 0 25 0
ABBVIE INC COM 00287Y959 7,505 776 SH Put DFND 1 0 776 0
ACHILLION PHARMACEUTICALS INC COM 00448Q201 48 16,705 SH   DFND 1 0 16,705 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 286 992 SH Call DFND 1 0 992 0
ACHILLION PHARMACEUTICALS INC COM 00448Q951 50 174 SH Put DFND 1 0 174 0
ADVAXIS INC COM 007624908 77 270 SH Call DFND 1 0 270 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 1,050 300,000 SH   DFND 1 0 300,000 0
AETERNA ZENTARIS INC COM 007975902 33 138 SH Call DFND 1 0 138 0
AETERNA ZENTARIS INC COM 007975952 46 264 SH Put DFND 1 0 264 0
AGENUS INC COM 00847G905 932 2,860 SH Call DFND 1 0 2,860 0
AGENUS INC COM 00847G955 38 116 SH Put DFND 1 0 116 0
AIMMUNE THERAPEUTICS INC COM 00900T107 213 5,629 SH   DFND 1 0 5,629 0
AIMMUNE THERAPEUTICS INC COM 00900T957 840 222 SH Put DFND 1 0 222 0
ALEXION PHARMACEUTICALS INC COM 015351909 2,954 247 SH Call DFND 1 0 247 0
ALEXION PHARMACEUTICALS INC COM 015351959 1,148 96 SH Put DFND 1 0 96 0
ALKERMES PLC SHS G01767905 8,751 1,599 SH Call DFND 1 0 1,599 0
ALKERMES PLC SHS G01767955 1,281 234 SH Put DFND 1 0 234 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 2,446 19,250 SH   DFND 1 0 19,250 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q907 11,955 941 SH Call DFND 1 0 941 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 20,366 1,603 SH Put DFND 1 0 1,603 0
AMAG PHARMACEUTICALS INC COM 00163U106 1,575 118,864 SH   DFND 1 0 118,864 0
AMAG PHARMACEUTICALS INC COM 00163U906 733 553 SH Call DFND 1 0 553 0
AMAG PHARMACEUTICALS INC COM 00163U956 2,414 1,822 SH Put DFND 1 0 1,822 0
AMARIN CORPORATION PLC ADR 023111906 970 2,418 SH Call DFND 1 0 2,418 0
AMICUS THERAPEUTICS INC COM 03152W909 14,924 10,371 SH Call DFND 1 0 10,371 0
AMICUS THERAPEUTICS INC COM 03152W959 2,878 2,000 SH Put DFND 1 0 2,000 0
AMYRIS INC COM 03236M950 94 250 SH Put DFND 1 0 250 0
ANTHERA PHARMACEUTICALS INC COM 03674U950 109 658 SH Put DFND 1 0 658 0
APPLIED DNA SCIENCES INC *W 03815U110 244 642,289 SH   DFND 1 0 642,289 0
APPLIED DNA SCIENCES INC COM 03815U201 1,482 932,350 SH   DFND 1 0 932,350 0
ARCA BIOPHARMA INC COM 00211Y407 138 100,000 SH   DFND 1 0 100,000 0
ASTRAZENECA PLC ADR 046353908 51,863 14,946 SH Call DFND 1 0 14,946 0
ASTRAZENECA PLC ADR 046353958 26,063 7,511 SH Put DFND 1 0 7,511 0
AVEO PHARMACEUTICALS INC COM 053588909 34 122 SH Call DFND 1 0 122 0
AXOVANT SCIENCES LTD COM G0750W104 608 115,462 SH   DFND 1 0 115,462 0
AXOVANT SCIENCES LTD COM G0750W904 1,131 2,146 SH Call DFND 1 0 2,146 0
AXOVANT SCIENCES LTD COM G0750W954 974 1,848 SH Put DFND 1 0 1,848 0
BENITEC BIOPHARMA LTD *W 082053117 36 90,193 SH   DFND 1 0 90,193 0
BIO PATH HOLDINGS INC COM 09057N102 371 1,833,449 SH   DFND 1 0 1,833,449 0
BIOAMBER INC COM 09072Q106 9 21,319 SH   DFND 1 0 21,319 0
BIOCEPT INC COM 09072V204 668 962,265 SH   DFND 1 0 962,265 0
BIOGEN INC COM 09062X953 879 230 SH Put DFND 1 0 230 0
BIOPHARMX CORP COM 09072X101 740 6,713,756 SH   DFND 1 0 6,713,756 0
BLUEBIRD BIO INC COM 09609G900 75,693 4,250 SH Call DFND 1 0 4,250 0
BLUEBIRD BIO INC COM 09609G950 8,638 485 SH Put DFND 1 0 485 0
BRISTOL MYERS SQUIBB CO COM 110122108 57,101 931,807 SH   DFND 1 0 931,807 0
BRISTOL MYERS SQUIBB CO COM 110122908 25,891 4,225 SH Call DFND 1 0 4,225 0
BRISTOL MYERS SQUIBB CO COM 110122958 212,531 34,682 SH Put DFND 1 0 34,682 0
CAPSTONE TURBINE CORP. COM 14067D409 758 983,787 SH   DFND 1 0 983,787 0
CHECK CAP LTD SHS M2361E112 876 1,007,494 SH   DFND 1 0 1,007,494 0
CHF SOLUTIONS INC COM 12542Q508 182 52,490 SH   DFND 1 0 52,490 0
CIGNA CORP COM 125509909 13,607 670 SH Call DFND 1 0 670 0
CITIUS PHARMACEUTICALS INC COM 17322U207 820 210,131 SH   DFND 1 0 210,131 0
CLOVIS ONCOLOGY INC COM 189464900 456 67 SH Call DFND 1 0 67 0
CONTRAFECT CORP. COM 212326102 35 34,333 SH   DFND 1 0 34,333 0
CYTORI THERAPEUTICS INC *W 23283K121 11 1,028,634 SH   DFND 1 0 1,028,634 0
DERMIRA INC COM 24983L104 1,260 45,304 SH   DFND 1 0 45,304 0
DERMIRA INC COM 24983L954 2,130 766 SH Put DFND 1 0 766 0
EDAP TMS SA ADR 268311957 413 1,440 SH Put DFND 1 0 1,440 0
EGALET CORP COM 28226B104 74 73,792 SH   DFND 1 0 73,792 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 684 49,000 SH   DFND 1 0 49,000 0
ESPERION THERAPEUTICS INC COM 29664W105 9,361 142,185 SH   DFND 1 0 142,185 0
ESPERION THERAPEUTICS INC COM 29664W905 757 115 SH Call DFND 1 0 115 0
ESPERION THERAPEUTICS INC COM 29664W955 10,995 1,670 SH Put DFND 1 0 1,670 0
FIBROCELL SCIENCE INC COM 315721308 733 1,128,588 SH   DFND 1 0 1,128,588 0
FIBROGEN INC COM 31572Q908 1,304 275 SH Call DFND 1 0 275 0
FUELCELL ENERGY INC COM 35952H952 55 1,236 SH Put DFND 1 0 1,236 0
GALECTIN THERAPEUTICS INC COM 363225952 378 1,131 SH Put DFND 1 0 1,131 0
GALENA BIOPHARMA INC COM 363256504 687 2,623,610 SH   DFND 1 0 2,623,610 0
GALENA BIOPHARMA INC COM 363256904 199 7,602 SH Call DFND 1 0 7,602 0
GILEAD SCIENCES INC COM 375558903 3,252 454 SH Call DFND 1 0 454 0
GW PHARMACEUTICALS PLC ADS 36197T953 4,662 353 SH Put DFND 1 0 353 0
HALOZYME THERAPEUTICS INC COM 40637H909 10,029 4,950 SH Call DFND 1 0 4,950 0
HEAT BIOLOGICS INC COM 42237K102 1,001 2,615,123 SH   DFND 1 0 2,615,123 0
HISTOGENICS CORP. COM 43358V109 1,958 955,060 SH   DFND 1 0 955,060 0
IDERA PHARMACEUTICALS INC COM 45168K306 650 307,987 SH   DFND 1 0 307,987 0
IMMUNOCELLULAR THERAPEUTICS *W 452536121 16 392,702 SH   DFND 1 0 392,702 0
IMMUNOMEDICS INC COM 452907958 2 305 SH Put DFND 1 0 305 0
IMMUTEP LTD ADR 45257L108 34 21,500 SH   DFND 1 0 21,500 0
INCYTE CORP COM 45337C902 5,039 532 SH Call DFND 1 0 532 0
INCYTE CORP COM 45337C952 9,812 1,036 SH Put DFND 1 0 1,036 0
INSPIREMD INC *W 45779A127 36 1,193,470 SH   DFND 1 0 1,193,470 0
INSPIREMD INC *W 45779A135 40 2,003,848 SH   DFND 1 0 2,003,848 0
INSPIREMD INC COM 45779A804 555 4,321,909 SH   DFND 1 0 4,321,909 0
INTELLIPHARMACEUTICS INTERNATIONAL INC COM 458173101 867 1,083,637 SH   DFND 1 0 1,083,637 0
INTERCEPT PHARMACEUTICALS INC COM 45845P908 2,611 447 SH Call DFND 1 0 447 0
INTERPACE DIAGNOSTICS GROUP COM 46062X204 1,346 1,319,290 SH   DFND 1 0 1,319,290 0
IONIS PHARMACEUTICALS INC COM 462222900 7,188 1,429 SH Call DFND 1 0 1,429 0
IONIS PHARMACEUTICALS INC COM 462222950 6,187 1,230 SH Put DFND 1 0 1,230 0
ISHARES RUSSELL 2000 ETF 464287905 64,109 4,205 SH Call DFND 1 0 4,205 0
JAGUAR HEALTH INC COM 47010C201 142 1,045,741 SH   DFND 1 0 1,045,741 0
JUNO THERAPEUTICS INC COM 48205A909 13,727 3,003 SH Call DFND 1 0 3,003 0
KAZIA THERAPEUTICS LTD ADR 48669G105 0 366,668 SH   DFND 1 0 366,668 0
LEAP THERAPEUTICS INC COM 52187K101 558 89,350 SH   DFND 1 0 89,350 0
MANNKIND CORP COM 56400P706 3,357 1,446,900 SH   DFND 1 0 1,446,900 0
MANNKIND CORP COM 56400P906 27 116 SH Call DFND 1 0 116 0
MANNKIND CORP COM 56400P956 1,895 8,169 SH Put DFND 1 0 8,169 0
MEDIGUS LTD ADR 58471G201 48 36,943 SH   DFND 1 0 36,943 0
MERCK & CO INC COM 58933Y905 102,535 18,222 SH Call DFND 1 0 18,222 0
MERCK & CO INC COM 58933Y955 14,923 2,652 SH Put DFND 1 0 2,652 0
MICROBOT MED INC COM 59503A105 1,275 1,250,000 SH   DFND 1 0 1,250,000 0
NABRIVA THERAPEUTICS PLC SHS G63637105 60 10,000 SH   DFND 1 0 10,000 0
NANOVIBRONIX INC COM 63008J108 477 101,949 SH   DFND 1 0 101,949 0
NEKTAR THERAPEUTICS COM 640268108 1,194 20,000 SH   DFND 1 0 20,000 0
NEKTAR THERAPEUTICS COM 640268908 3,326 557 SH Call DFND 1 0 557 0
NEUROMETRIX INC COM 641255708 310 180,039 SH   DFND 1 0 180,039 0
OASMIA PHARMACEUTICAL ADR 67421W109 17 19,000 SH   DFND 1 0 19,000 0
ODONATE THERAPEUTICS INC COM 676079106 20,636 825,451 SH   DFND 1 0 825,451 0
ONCOBIOLOGICS INC COM 68235M105 2,703 2,079,367 SH   DFND 1 0 2,079,367 0
ONCOBIOLOGICS INC *W 68235M113 3 89,644 SH   DFND 1 0 89,644 0
ONCOBIOLOGICS INC *W 68235M121 4 199,193 SH   DFND 1 0 199,193 0
ONCONOVA THERAPEUTICS INC *W 68232V116 225 643,244 SH   DFND 1 0 643,244 0
ONCONOVA THERAPEUTICS INC COM 68232V306 842 561,163 SH   DFND 1 0 561,163 0
ONCOSEC MEDICAL INC COM 68234L207 249 153,137 SH   DFND 1 0 153,137 0
OPGEN INC COM 68373L109 211 1,129,867 SH   DFND 1 0 1,129,867 0
OVASCIENCE INC COM 69014Q101 840 600,000 SH   DFND 1 0 600,000 0
PROQR THERAPEUTICS N V SHS N71542109 1,120 347,245 SH   DFND 1 0 347,245 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 350 60,000 SH   DFND 1 0 60,000 0
PROTHENA CORPORATION PLC SHS G72800108 927 24,730 SH   DFND 1 0 24,730 0
PROTHENA CORPORATION PLC SHS G72800908 900 240 SH Call DFND 1 0 240 0
PROTHENA CORPORATION PLC SHS G72800958 1,616 431 SH Put DFND 1 0 431 0
RADIUS HEALTH INC COM 750469907 4,880 1,536 SH Call DFND 1 0 1,536 0
REDHILL BIOPHARMA LTD ADS 757468103 110 21,322 SH   DFND 1 0 21,322 0
REGENXBIO INC COM 75901B907 269 81 SH Call DFND 1 0 81 0
RITTER PHARMACEUTICALS INC COM 767836109 118 357,781 SH   DFND 1 0 357,781 0
RXI PHARMACEUTICALS CORP *W 74979C113 273 2,100,797 SH   DFND 1 0 2,100,797 0
SAGE THERAPEUTICS INC COM 78667J908 5,765 350 SH Call DFND 1 0 350 0
SAGE THERAPEUTICS INC COM 78667J958 4,266 259 SH Put DFND 1 0 259 0
SANGAMO THERAPEUTICS INC COM 800677906 9,906 6,040 SH Call DFND 1 0 6,040 0
SANGAMO THERAPEUTICS INC COM 800677956 4,477 2,730 SH Put DFND 1 0 2,730 0
SAREPTA THERAPEUTICS INC COM 803607900 50,204 9,023 SH Call DFND 1 0 9,023 0
SAREPTA THERAPEUTICS INC COM 803607950 8,190 1,472 SH Put DFND 1 0 1,472 0
SENESTECH INC COM 81720R109 315 436,863 SH   DFND 1 0 436,863 0
SIGMA LABS INC *W 826598112 184 382,868 SH   DFND 1 0 382,868 0
SOLENO THERAPEUTICS INC COM 834203200 1,647 915,100 SH   DFND 1 0 915,100 0
SOPHIRIS BIO INC COM 83578Q209 127 55,907 SH   DFND 1 0 55,907 0
SOPHIRIS BIO INC COM 83578Q959 62 275 SH Put DFND 1 0 275 0
SPARK THERAPEUTICS INC COM 84652J103 5,699 110,827 SH   DFND 1 0 110,827 0
SPDR S&P 500 TR 78462F903 53,558 3,000 SH Call DFND 1 0 3,000 0
SPDR S&P BIOTECH S&P BIOTECH 78464A970 5,567 656 SH Call DFND 1 0 656 0
STRATA SKIN SCIENCES INC. COM 86272A206 416 335,105 SH   DFND 1 0 335,105 0
SUNESIS PHARMACEUTICALS INC COM 867328700 461 125,000 SH   DFND 1 0 125,000 0
SUNESIS PHARMACEUTICALS INC COM 867328900 327 885 SH Call DFND 1 0 885 0
SYNERGY PHARMACEUTICALS INC COM 871639908 946 4,243 SH Call DFND 1 0 4,243 0
TANDEM DIABETES CARE INC. COM 875372203 65 27,487 SH   DFND 1 0 27,487 0
TESARO INC COM 881569107 804 9,700 SH   DFND 1 0 9,700 0
TESARO INC COM 881569907 704 85 SH Call DFND 1 0 85 0
TESARO INC COM 881569957 862 104 SH Put DFND 1 0 104 0
TRANSENTERIX INC COM 89366M201 1,367 708,097 SH   DFND 1 0 708,097 0
TRANSENTERIX INC COM 89366M951 589 3,050 SH Put DFND 1 0 3,050 0
VERSARTIS INC COM 92529L102 2,185 993,100 SH   DFND 1 0 993,100 0
VERTEX PHARMACEUTICALS INC COM 92532F900 13,772 919 SH Call DFND 1 0 919 0
VERTEX PHARMACEUTICALS INC COM 92532F950 7,283 486 SH Put DFND 1 0 486 0
VICAL ORD SHS COM 925602203 503 275,090 SH   DFND 1 0 275,090 0
VISTAGEN THERAPEUTICS INC COM 92840H202 2,352 2,115,873 SH   DFND 1 0 2,115,873 0
VTV THERAPEUTICS INC CL A 918385105 267 44,500 SH   DFND 1 0 44,500 0
XENON PHARMACEUTICALS INC COM 98420N105 931 329,400 SH   DFND 1 0 329,400 0
YIELD10 BIOSCIENCE INC COM 98585K201 381 215,250 SH   DFND 1 0 215,250 0
ZOGENIX INC COM 98978L904 12,375 3,090 SH Call DFND 1 0 3,090 0
ZOGENIX INC COM 98978L954 4,462 1,114 SH Put DFND 1 0 1,114 0