The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y909 94,858 10,675 SH Call DFND 1 0 10,675 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 445 992 SH Call DFND 1 0 992 0
ACTINIUM PHARMACEUTICALS INC. COM 00507W107 1,400 2,434,103 SH   DFND 1 0 2,434,103 0
ADAMIS PHARMACEUTICALS INC COM 00547W958 300 574 SH Put DFND 1 0 574 0
ADAMIS PHARMACEUTICALS INC COM 00547W208 524 100,378 SH   DFND 1 0 100,378 0
ADVAXIS INC COM 007624908 113 270 SH Call DFND 1 0 270 0
ADVAXIS INC COM 007624208 157 37,634 SH   DFND 1 0 37,634 0
ADVAXIS INC COM 007624958 173 414 SH Put DFND 1 0 414 0
AERIE PHARMACEUTICALS INC COM 00771V108 230 4,726 SH   DFND 1 0 4,726 0
AERIE PHARMACEUTICALS INC COM 00771V958 360 74 SH Put DFND 1 0 74 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 37,186 3,165 SH Put DFND 1 0 3,165 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q907 54,985 4,680 SH Call DFND 1 0 4,680 0
AMAG PHARMACEUTICALS INC COM 00163U906 469 254 SH Call DFND 1 0 254 0
AMAG PHARMACEUTICALS INC COM 00163U106 1,478 80,108 SH   DFND 1 0 80,108 0
AMAG PHARMACEUTICALS INC COM 00163U956 5,542 3,004 SH Put DFND 1 0 3,004 0
AMARIN CORPORATION PLC COM 023111906 4,428 12,650 SH Call DFND 1 0 12,650 0
AMICUS THERAPEUTICS INC COM 03152W959 754 500 SH Put DFND 1 0 500 0
AMICUS THERAPEUTICS INC COM 03152W909 6,240 4,138 SH Call DFND 1 0 4,138 0
AMPLIPHI BIOSCIENCES CORP. COM 03211P301 136 149,248 SH   DFND 1 0 149,248 0
ANTARES PHARMA INC COM 036642956 74 227 SH Put DFND 1 0 227 0
ANTARES PHARMA INC COM 036642906 329 1,016 SH Call DFND 1 0 1,016 0
ANTHERA PHARMACEUTICALS INC COM 03674U300 75 52,046 SH   DFND 1 0 52,046 0
APPLIED DNA SCIENCES INC *W 03815U110 575 857,768 SH   DFND 1 0 857,768 0
ARCA BIOPHARMA INC COM 00211Y407 110 100,000 SH   DFND 1 0 100,000 0
ASTRAZENECA PLC ADR 046353958 6,922 2,043 SH Put DFND 1 0 2,043 0
ASTRAZENECA PLC ADR 046353908 15,209 4,489 SH Call DFND 1 0 4,489 0
AXOVANT SCIENCES LTD COM G0750W904 874 1,270 SH Call DFND 1 0 1,270 0
AXOVANT SCIENCES LTD COM G0750W104 4,421 642,557 SH   DFND 1 0 642,557 0
AXOVANT SCIENCES LTD COM G0750W954 5,283 7,679 SH Put DFND 1 0 7,679 0
BARCLAYS BANK PLC IPATH 06740Q260 551 26,500 SH   DFND 1 0 26,500 0
BENITEC BIOPHARMA LTD *W 082053117 27 90,193 SH   DFND 1 0 90,193 0
BIOAMBER INC COM 09072Q106 1,559 3,180,973 SH   DFND 1 0 3,180,973 0
BIONDVAX PHARMACEUTICALS LTD ADR 09073Q105 139 19,376 SH   DFND 1 0 19,376 0
BLUEBIRD BIO INC COM 09609G950 7,760 565 SH Put DFND 1 0 565 0
BLUEBIRD BIO INC COM 09609G900 53,992 3,931 SH Call DFND 1 0 3,931 0
BRISTOL MYERS SQUIBB COM 110122908 26,962 4,230 SH Call DFND 1 0 4,230 0
BRISTOL MYERS SQUIBB COM 110122108 62,654 982,955 SH   DFND 1 0 982,955 0
BRISTOL MYERS SQUIBB COM 110122958 210,782 33,069 SH Put DFND 1 0 33,069 0
CEL SCI CORP. COM 150837607 976 587,822 SH   DFND 1 0 587,822 0
CELSION CORP. COM 15117N503 101 67,403 SH   DFND 1 0 67,403 0
CHECK CAP LTD SHS M2361E112 2,121 1,184,917 SH   DFND 1 0 1,184,917 0
CHF SOLUTIONS INC COM 12542Q102 216 367,893 SH   DFND 1 0 367,893 0
CIDARA THERAPEUTICS INC COM 171757107 521 64,300 SH   DFND 1 0 64,300 0
CIGNA CORP COM 125509909 12,525 670 SH Call DFND 1 0 670 0
CLOVIS ONCOLOGY INC COM 189464900 9,163 1,112 SH Call DFND 1 0 1,112 0
CONTRAFECT CORP. COM 212326102 132 119,156 SH   DFND 1 0 119,156 0
CORMEDIX INC COM 21900C100 337 648,955 SH   DFND 1 0 648,955 0
CYTOKINETICS INC COM 23282W955 344 237 SH Put DFND 1 0 237 0
CYTOKINETICS INC COM 23282W905 4,927 3,398 SH Call DFND 1 0 3,398 0
CYTORI THERAPEUTICS INC *W 23283K121 45 1,237,952 SH   DFND 1 0 1,237,952 0
CYTRX CORP COM 232828959 4 100 SH Put DFND 1 0 100 0
DBV TECHNOLOGIES SA ADR 23306J951 7,571 1,784 SH Put DFND 1 0 1,784 0
DBV TECHNOLOGIES SA ADR 23306J901 46,294 10,908 SH Call DFND 1 0 10,908 0
DELMAR PHARMACEUTICALS INC. COM 247078207 1,782 2,121,202 SH   DFND 1 0 2,121,202 0
EDAP TMS SA ADR 268311957 663 2,224 SH Put DFND 1 0 2,224 0
EGALET CORP COM 28226B104 923 721,050 SH   DFND 1 0 721,050 0
EIGER BIOPHARMACEUTICALS COM 28249U105 1,018 92,500 SH   DFND 1 0 92,500 0
EKSO BIONICS HOLDINGS INC COM 282644202 850 702,364 SH   DFND 1 0 702,364 0
ESPERION THERAPEUTICS INC COM 29664W105 4,178 83,357 SH   DFND 1 0 83,357 0
ESPERION THERAPEUTICS INC COM 29664W955 7,413 1,479 SH Put DFND 1 0 1,479 0
EYEGATE PHARMACEUTICALS INC COM 30233M107 54 46,378 SH   DFND 1 0 46,378 0
FIBROGEN INC COM 31572Q908 7,446 1,384 SH Call DFND 1 0 1,384 0
FIVE PRIME THERAPEUTICS INC COM 33830X954 3,101 758 SH Put DFND 1 0 758 0
FLEXION THERAPEUTICS INC COM 33938J956 706 292 SH Put DFND 1 0 292 0
FLEXION THERAPEUTICS INC COM 33938J906 825 341 SH Call DFND 1 0 341 0
FUELCELL ENERGY INC COM 35952H502 21 11,968 SH   DFND 1 0 11,968 0
FUELCELL ENERGY INC COM 35952H952 42 239 SH Put DFND 1 0 239 0
GALECTIN THERAPEUTICS INC COM 363225952 72 337 SH Put DFND 1 0 337 0
GALENA BIOPHARMA INC COM 363256904 215 6,084 SH Call DFND 1 0 6,084 0
GALENA BIOPHARMA INC COM 363256504 953 2,702,228 SH   DFND 1 0 2,702,228 0
GEVO INC COM 374396307 140 224,810 SH   DFND 1 0 224,810 0
GILEAD SCIENCES INC COM 375558903 3,678 454 SH Call DFND 1 0 454 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 935 301 SH Call DFND 1 0 301 0
GW PHARMACEUTICALS PLC ADS 36197T103 2,894 28,517 SH   DFND 1 0 28,517 0
GW PHARMACEUTICALS PLC ADS 36197T953 11,661 1,149 SH Put DFND 1 0 1,149 0
HALOZYME THERAPEUTICS INC COM 40637H909 22,645 13,037 SH Call DFND 1 0 13,037 0
HEAT BIOLOGICS INC COM 42237K102 1,118 1,712,481 SH   DFND 1 0 1,712,481 0
HISTOGENICS CORP COM 43358V109 954 481,667 SH   DFND 1 0 481,667 0
IDERA PHARMACEUTICALS INC COM 45168K906 93 416 SH Call DFND 1 0 416 0
IDERA PHARMACEUTICALS INC COM 45168K306 346 155,027 SH   DFND 1 0 155,027 0
IMMUNOCELLULAR THERAPEUTICS *W 452536121 8 420,103 SH   DFND 1 0 420,103 0
IMMUNOMEDICS INC COM 452907908 1,848 1,322 SH Call DFND 1 0 1,322 0
INCYTE CORP COM 45337C952 2,148 184 SH Put DFND 1 0 184 0
INCYTE CORP COM 45337C902 4,459 382 SH Call DFND 1 0 382 0
INSMED INC COM 457669907 4,291 1,375 SH Call DFND 1 0 1,375 0
INSMED INC COM 457669957 5,777 1,851 SH Put DFND 1 0 1,851 0
INSPIREMD EQUITY *W 45779A135 40 2,002,648 SH   DFND 1 0 2,002,648 0
INSPIREMD EQUITY *W 45779A127 41 1,194,322 SH   DFND 1 0 1,194,322 0
INTELLIA THERAPEUTICS INC COM 45826J105 280 11,281 SH   DFND 1 0 11,281 0
INTERCEPT PHARMACEUTICALS INC COM 45845P908 580 100 SH Call DFND 1 0 100 0
IONIS PHARMACEUTICALS INC COM 462222900 7,215 1,423 SH Call DFND 1 0 1,423 0
IONIS PHARMACEUTICALS INC COM 462222950 8,173 1,612 SH Put DFND 1 0 1,612 0
ISHARES RUSSELL 2000 ETF 464287955 88,612 5,980 SH Put DFND 1 0 5,980 0
JAGUAR HEALTH COM 47010C201 437 2,185,555 SH   DFND 1 0 2,185,555 0
KADMON HOLDINGS INC COM 48283N106 1,761 525,695 SH   DFND 1 0 525,695 0
KITE PHARMA INC COM 49803L959 9,764 543 SH Put DFND 1 0 543 0
KRYSTAL BIOTECH INC COM 501147102 534 53,558 SH   DFND 1 0 53,558 0
MANNKIND CORP COM 56400P906 375 1,727 SH Call DFND 1 0 1,727 0
MANNKIND CORP COM 56400P956 1,312 6,048 SH Put DFND 1 0 6,048 0
MEDICINES CO COM 584688905 244 66 SH Call DFND 1 0 66 0
MEDIGUS LTD ADR 58471G201 578 258,095 SH   DFND 1 0 258,095 0
MERCK & CO INC COM 58933Y955 26,758 4,179 SH Put DFND 1 0 4,179 0
MERCK & CO INC COM 58933Y905 282,622 44,139 SH Call DFND 1 0 44,139 0
MICROBOT MED INC COM 59503A105 1,464 1,251,398 SH   DFND 1 0 1,251,398 0
NEUROMETRIX INC. COM 641255708 190 93,561 SH   DFND 1 0 93,561 0
NEWLINK GENETICS CORP COM 651511957 124 122 SH Put DFND 1 0 122 0
NEWLINK GENETICS CORP COM 651511907 1,018 1,000 SH Call DFND 1 0 1,000 0
OASMIA PHARMACEUTICAL ADR 67421W109 20 19,000 SH   DFND 1 0 19,000 0
OHR PHARMACEUTICAL INC COM 67778H200 110 152,127 SH   DFND 1 0 152,127 0
ONCOBIOLOGICS INC *W 68235M121 13 260,018 SH   DFND 1 0 260,018 0
ONCOBIOLOGICS INC *W 68235M113 18 158,295 SH   DFND 1 0 158,295 0
ONCOBIOLOGICS INC COM 68235M105 3,266 2,383,971 SH   DFND 1 0 2,383,971 0
ONCONOVA THERAPEUTICS INC *W 68232V116 252 645,350 SH   DFND 1 0 645,350 0
ONCONOVA THERAPEUTICS INC COM 68232V306 1,438 840,960 SH   DFND 1 0 840,960 0
ONCOSEC MEDICAL INC COM 68234L207 968 1,010,143 SH   DFND 1 0 1,010,143 0
OPGEN INC COM 68373L109 514 1,659,500 SH   DFND 1 0 1,659,500 0
OREXIGEN THERAPEUTICS INC COM 686164302 42 19,700 SH   DFND 1 0 19,700 0
OREXIGEN THERAPEUTICS INC COM 686164952 42 197 SH Put DFND 1 0 197 0
OTONOMY INC COM 68906L905 89 275 SH Call DFND 1 0 275 0
OVASCIENCE INC COM 69014Q101 781 550,000 SH   DFND 1 0 550,000 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 315 150,151 SH   DFND 1 0 150,151 0
PROTHENA CORPORATION PLC SHS G72800908 6,471 999 SH Call DFND 1 0 999 0
PTC THERAPEUTICS INC COM 69366J900 2,555 1,277 SH Call DFND 1 0 1,277 0
REGENXBIO INC COM 75901B907 257 78 SH Call DFND 1 0 78 0
RENNOVA HEALTH INC COM 759757602 91 466,880 SH   DFND 1 0 466,880 0
REXAHN PHARMACEUTICALS INC COM 761640200 411 169,901 SH   DFND 1 0 169,901 0
RICEBRAN TECHNOLOGIES COM 762831204 575 442,033 SH   DFND 1 0 442,033 0
RITTER PHARMACEUTICALS INC COM 767836109 1,630 4,657,800 SH   DFND 1 0 1,357,800 0
ROKA BIOSCIENCE INC COM 775431208 173 237,322 SH   DFND 1 0 237,322 0
ROSETTA GENOMICS LTD SHS M82183209 149 141,741 SH   DFND 1 0 141,741 0
RXI PHARMACEUTICALS CORP *W 74979C113 355 2,100,797 SH   DFND 1 0 2,100,797 0
SAGE THERAPEUTICS INC COM 78667J908 4,373 702 SH Call DFND 1 0 702 0
SANGAMO THERAPEUTICS INC COM 800677956 863 575 SH Put DFND 1 0 575 0
SANGAMO THERAPEUTICS INC COM 800677906 5,976 3,984 SH Call DFND 1 0 3,984 0
SAREPTA THERAPEUTICS INC COM 803607950 2,350 518 SH Put DFND 1 0 518 0
SAREPTA THERAPEUTICS INC COM 803607900 32,945 7,263 SH Call DFND 1 0 7,263 0
SEATTLE GENETICS INC COM 812578102 2,320 42,646 SH   DFND 1 0 42,646 0
SEATTLE GENETICS INC COM 812578902 2,949 542 SH Call DFND 1 0 542 0
SEATTLE GENETICS INC COM 812578952 9,435 1,734 SH Put DFND 1 0 1,734 0
SIERRA ONCOLOGY INC COM 82640U107 827 533,563 SH   DFND 1 0 533,563 0
SIGMA LABS INC *W 826598112 131 246,519 SH   DFND 1 0 246,519 0
SIGMA LABS INC COM 826598302 132 70,000 SH   DFND 1 0 70,000 0
SOPHIRIS BIO INC COM 83578Q959 24 112 SH Put DFND 1 0 112 0
SOPHIRIS BIO INC COM 83578Q209 716 333,641 SH   DFND 1 0 333,641 0
SPDR S&P 500 ETF TR 78462F953 125,615 5,000 SH Put DFND 1 0 5,000 0
STEMLINE THERAPEUTICS INC COM 85858C107 486 43,749 SH   DFND 1 0 43,749 0
STEMLINE THERAPEUTICS INC COM 85858C907 890 802 SH Call DFND 1 0 802 0
STRATA SKIN SCIENCES INC COM 86272A206 375 211,695 SH   DFND 1 0 211,695 0
SUNESIS PHARMACEUTICALS INC COM 867328700 473 243,638 SH   DFND 1 0 243,638 0
TESARO INC COM 881569107 452 3,500 SH   DFND 1 0 3,500 0
TESARO INC COM 881569907 1,291 100 SH Call DFND 1 0 100 0
TESARO INC COM 881569957 1,343 104 SH Put DFND 1 0 104 0
TRANSENTERIX INC COM 89366M951 490 3,426 SH Put DFND 1 0 3,426 0
TROVAGENE INC COM 897238309 1,234 1,689,778 SH   DFND 1 0 1,689,778 0
UNITED THERAPEUTICS CORP COM 91307C902 6,352 542 SH Call DFND 1 0 542 0
VERSARTIS INC COM 92529L902 155 632 SH Call DFND 1 0 632 0
VERSARTIS INC COM 92529L102 1,733 707,300 SH   DFND 1 0 707,300 0
VERTEX PHARMACEUTICALS INC COM 92532F950 19,111 1,257 SH Put DFND 1 0 1,257 0
VERTEX PHARMACEUTICALS INC COM 92532F900 43,559 2,865 SH Call DFND 1 0 2,865 0
VTV THERAPEUTICS INC CL A 918385105 364 60,897 SH   DFND 1 0 60,897 0
WAVE LIFE SCIENCES LTD SHS Y95308105 1,631 75,000 SH   DFND 1 0 75,000 0
XENON PHARMACEUTICALS INC COM 98420N105 907 307,600 SH   DFND 1 0 307,600 0
ZOGENIX INC COM 98978L954 4,469 1,275 SH Put DFND 1 0 1,275 0
ZOGENIX INC COM 98978L904 17,052 4,865 SH Call DFND 1 0 4,865 0