The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y909 108,615 16,669 SH Call DFND 1 0 16,669 0
ABBVIE INC COM 00287Y959 4,652 714 SH Put DFND 1 0 714 0
ACCELERON PHARMA INC COM 00434H908 244 92 SH Call DFND 1 0 92 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 2,679 6,363 SH Call DFND 1 0 6,363 0
ACORDA THERAPEUTICS INC COM 00484M906 313 149 SH Call DFND 1 0 149 0
ACORDA THERAPEUTICS INC COM 00484M106 1,609 76,610 SH   DFND 1 0 76,610 0
ACORDA THERAPEUTICS INC COM 00484M956 14,696 6,998 SH Put DFND 1 0 6,998 0
ADAMAS PHARMACEUTICALS INC COM 00548A956 439 931 SH Put DFND 1 0 931 0
ADVAXIS INC COM 007624908 221 270 SH Call DFND 1 0 270 0
ADVAXIS INC COM 007624958 338 414 SH Put DFND 1 0 414 0
ADVERUM BIOTECHNOLOGIES COM 00773U108 763 282,630 SH   DFND 1 0 282,630 0
AETERNA ZENTARIS INC COM 007975952 50 166 SH Put DFND 1 0 166 0
AEVI GENOMIC MEDICINE INC COM 00835P105 37 19,888 SH   DFND 1 0 19,888 0
AEVI GENOMIC MEDICINE INC COM 00835P905 84 450 SH Call DFND 1 0 450 0
ALDEYRA THERAPEUTICS INC COM 01438T106 898 179,627 SH   DFND 1 0 179,627 0
ALEXION PHARMACEUTICALS INC COM 015351959 6,668 550 SH Put DFND 1 0 550 0
ALEXION PHARMACEUTICALS INC COM 015351909 34,153 2,817 SH Call DFND 1 0 2,817 0
ALKERMES PLC SHS G01767905 418 708 SH Call DFND 1 0 708 0
ALLIQUA BIOMEDICAL INC. COM 019621200 1,076 2,131,050 SH   DFND 1 0 2,131,050 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q907 10,071 1,965 SH Call DFND 1 0 1,965 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 12,695 2,477 SH Put DFND 1 0 2,477 0
AMAG PHARMACEUTICALS INC COM 00163U906 246 109 SH Call DFND 1 0 109 0
AMAG PHARMACEUTICALS INC COM 00163U106 1,697 75,263 SH   DFND 1 0 75,263 0
AMARIN CORP PLC COM 023111906 4,274 13,355 SH Call DFND 1 0 13,355 0
AMEDICA CORP. COM 023435209 751 1,857,578 SH   DFND 1 0 1,857,578 0
AMGEN INC COM 031162100 6,088 37,104 SH   DFND 1 0 37,104 0
AMGEN INC COM 031162900 13,093 798 SH Call DFND 1 0 798 0
AMGEN INC COM 031162950 50,123 3,055 SH Put DFND 1 0 3,055 0
AMICUS THERAPEUTICS INC COM 03152W959 1,598 2,241 SH Put DFND 1 0 2,241 0
AMICUS THERAPEUTICS INC COM 03152W909 3,104 4,353 SH Call DFND 1 0 4,353 0
AMPLIPHI BIOSCIENCES ORD SHS COM 03211P202 507 304,919 SH   DFND 1 0 304,919 0
ANTHERA PHARMACEUTICALS INC COM 03674U201 748 1,757,697 SH   DFND 1 0 1,757,697 0
APPLIED DNA SCIENCES *W 03815U110 985 2,431,089 SH   DFND 1 0 2,431,089 0
APPLIED DNA SCIENCES COM 03815U201 2,930 1,771,839 SH   DFND 1 0 1,771,839 0
ARBUTUS BIOPHARMA CORP COM 03879J900 102 315 SH Call DFND 1 0 315 0
ARBUTUS BIOPHARMA CORP COM 03879J100 2,107 648,200 SH   DFND 1 0 648,200 0
ARDELYX INC. COM 039697957 40 160 SH Put DFND 1 0 160 0
ARRAY BIOPHARMA INC COM 04269X105 1,395 156,074 SH   DFND 1 0 156,074 0
ARRAY BIOPHARMA INC COM 04269X955 2,235 2,500 SH Put DFND 1 0 2,500 0
ASTRAZENECA PLC ADR 046353958 13,197 4,238 SH Put DFND 1 0 4,238 0
ASTRAZENECA PLC ADR 046353908 45,695 14,674 SH Call DFND 1 0 14,674 0
AURIS MEDICAL HOLDING AG COM H03579101 133 144,900 SH   DFND 1 0 144,900 0
AVEO PHARMACEUTICALS INC COM 053588109 513 868,900 SH   DFND 1 0 868,900 0
AVEXIS INC COM 05366U900 2,281 300 SH Call DFND 1 0 300 0
AXOVANT SCIENCES LTD COM G0750W104 250 16,715 SH   DFND 1 0 16,715 0
AXOVANT SCIENCES LTD COM G0750W954 5,438 3,640 SH Put DFND 1 0 3,640 0
AXOVANT SCIENCES LTD COM G0750W904 6,890 4,612 SH Call DFND 1 0 4,612 0
AZURRX BIOPHARMA INC COM 05502L105 462 119,693 SH   DFND 1 0 119,693 0
BARCLAYS BANK PLC IPATH 06740Q260 1,315 50,000 SH   DFND 1 0 50,000 0
BELLICUM PHARMACEUTICALS INC COM 079481107 895 72,500 SH   DFND 1 0 72,500 0
BENITEC BIOPHARMA LTD *W 082053117 37 125,163 SH   DFND 1 0 125,163 0
BIO PATH HOLDINGS INC. COM 09057N102 569 687,398 SH   DFND 1 0 687,398 0
BIOAMBER INC COM 09072Q106 3,388 1,460,859 SH   DFND 1 0 1,460,859 0
BIOBLAST PHARMA LTD SHS M20156101 167 219,905 SH   DFND 1 0 219,905 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 1,279 673,342 SH   DFND 1 0 673,342 0
BIOLINERX LTD ADR 09071M106 3,018 3,141,756 SH   DFND 1 0 3,141,756 0
BIOMARIN PHARMACEUTICAL INC COM 09061G901 17,284 1,969 SH Call DFND 1 0 1,969 0
BLUEBIRD BIO INC COM 09609G950 654 72 SH Put DFND 1 0 72 0
BLUEBIRD BIO INC COM 09609G900 17,262 1,899 SH Call DFND 1 0 1,899 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,000 50,000 SH   DFND 1 0 50,000 0
BRAINSTORM CELL THERAPEUTICS INC. COM 10501E901 296 69,544 SH   DFND 1 0 69,544 0
BRISTOL MYERS SQUIBB CO. COM 110122108 7,569 139,180 SH   DFND 1 0 139,180 0
BRISTOL MYERS SQUIBB CO. COM 110122908 76,235 14,019 SH Call DFND 1 0 14,019 0
BRISTOL MYERS SQUIBB CO. COM 110122958 100,456 18,473 SH Put DFND 1 0 18,473 0
CAN-FITE BIOPHARMA LTD ADR 13471N102 57 30,017 SH   DFND 1 0 30,017 0
CAPNIA INC COM 14066L105 159 233,938 SH   DFND 1 0 233,938 0
CAPRICOR THERAPEUTICS INC COM 14070B101 791 237,589 SH   DFND 1 0 237,589 0
CARDIOME PHARMA CORP COM 14159U301 819 273,010 SH   DFND 1 0 273,010 0
CASCADIAN THERAPEUTICS INC COM 14740B606 669 161,670 SH   DFND 1 0 161,670 0
CEL SCI CORP COM 150837508 154 1,799,815 SH   DFND 1 0 1,799,815 0
CHAMPIONS ONCOLOGY INC COM 15870P307 227 71,700 SH   DFND 1 0 71,700 0
CHECK CAP LTD SHS M2361E112 527 249,832 SH   DFND 1 0 249,832 0
CHIMERIX INC COM 16934W106 135 21,200 SH   DFND 1 0 21,200 0
CIDARA THERAPEUTICS INC COM 171757107 1,385 177,600 SH   DFND 1 0 177,600 0
CIGNA CORP COM 125509909 23,145 1,580 SH Call DFND 1 0 1,580 0
CLOVIS ONCOLOGY INC COM 189464900 20,705 3,252 SH Call DFND 1 0 3,252 0
COHERUS BIOSCIENCES INC COM 19249H103 1,973 93,308 SH   DFND 1 0 93,308 0
COHERUS BIOSCIENCES INC COM 19249H953 2,826 1,336 SH Put DFND 1 0 1,336 0
COMBIMATRIX CORP *W 20009T147 762 619,750 SH   DFND 1 0 619,750 0
CURIS INC COM 231269951 10 187 SH Put DFND 1 0 187 0
CYTOKINETICS INC COM 23282W905 2,600 2,023 SH Call DFND 1 0 2,023 0
CYTORI THERAPEUTICS INC *W 23283K121 757 1,261,647 SH   DFND 1 0 1,261,647 0
CYTORI THERAPEUTICS INC COM 23283K204 2,034 1,271,303 SH   DFND 1 0 1,271,303 0
CYTOSORBENTS CORP COM 23283X206 990 220,000 SH   DFND 1 0 220,000 0
CYTRX CORP COM 232828509 440 989,600 SH   DFND 1 0 989,600 0
DICERNA PHARMACEUTICALS INC COM 253031108 680 200,000 SH   DFND 1 0 200,000 0
DRAGONWAVE INC. COM 26144M400 677 466,696 SH   DFND 1 0 466,696 0
DURECT CORP COM 266605904 653 6,215 SH Call DFND 1 0 6,215 0
DURECT CORP COM 266605104 1,743 1,659,610 SH   DFND 1 0 1,659,610 0
DYNAVAX TECHNOLOGIES CORP COM 268158951 130 219 SH Put DFND 1 0 219 0
DYNAVAX TECHNOLOGIES CORP COM 268158901 6,997 11,760 SH Call DFND 1 0 11,760 0
EDAP TMS SA ADR 268311957 540 1,943 SH Put DFND 1 0 1,943 0
EDITAS MEDICINE INC COM 28106W903 1,750 784 SH Call DFND 1 0 784 0
EDITAS MEDICINE INC COM 28106W103 2,015 90,300 SH   DFND 1 0 90,300 0
EIGER BIOPHARMACEUTICALS ORD SHS COM 28249U105 2,735 238,907 SH   DFND 1 0 238,907 0
EKSO BIONICS HOLDINGS INC COM 282644952 53 130 SH Put DFND 1 0 130 0
ESPERION THERAPEUTICS INC COM 29664W955 907 257 SH Put DFND 1 0 257 0
ESPERION THERAPEUTICS INC COM 29664W905 1,130 320 SH Call DFND 1 0 320 0
EXELIXIS INC COM 30161Q954 1,084 500 SH Put DFND 1 0 500 0
EXELIXIS INC COM 30161Q904 3,684 1,700 SH Call DFND 1 0 1,700 0
FIBROGEN INC COM 31572Q908 2,317 940 SH Call DFND 1 0 940 0
FLEXION THERAPEUTICS INC COM 33938J906 1,389 516 SH Call DFND 1 0 516 0
FLEXION THERAPEUTICS INC COM 33938J956 1,773 659 SH Put DFND 1 0 659 0
FOAMIX PHARMACEUTICALS LTD SHS M46135905 91 184 SH Call DFND 1 0 184 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 173 35,037 SH   DFND 1 0 35,037 0
FORWARD PHARMA A/S ADR 34986J105 733 34,000 SH   DFND 1 0 34,000 0
GALECTIN THERAPEUTICS INC COM 363225952 193 840 SH Put DFND 1 0 840 0
GALENA BIOPHARMA INC COM 363256904 371 6,084 SH Call DFND 1 0 6,084 0
GALENA BIOPHARMA INC COM 363256504 1,504 2,465,860 SH   DFND 1 0 2,465,860 0
GENETIC TECHNOLOGIES LTD ADR 37185R208 678 570,073 SH   DFND 1 0 570,073 0
GEVO INC COM 374396307 1,274 1,148,755 SH   DFND 1 0 1,148,755 0
GILEAD SCIENCES INC COM 375558903 56,279 8,286 SH Call DFND 1 0 8,286 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 1,492 405 SH Call DFND 1 0 405 0
GREAT PANTHER SILVER LTD COM 39115V951 331 2,017 SH Put DFND 1 0 2,017 0
GW PHARMACEUTICALS PLC ADS 36197T953 5,600 463 SH Put DFND 1 0 463 0
GW PHARMACEUTICALS PLC ADS 36197T903 12,989 1,074 SH Call DFND 1 0 1,074 0
HALOZYME THERAPEUTICS INC COM 40637H909 4,209 3,248 SH Call DFND 1 0 3,248 0
HCA HOLDINGS INC COM 40412C901 6,674 750 SH Call DFND 1 0 750 0
HEAT BIOLOGICS INC COM 42237K102 2,176 2,445,240 SH   DFND 1 0 2,445,240 0
HEMISPHERX BIOPHARMA INC COM 42366C301 638 1,170,793 SH   DFND 1 0 1,170,793 0
HESS CORP COM 42809H907 2 250 SH Call DFND 1 0 250 0
HISTOGENICS CORP COM 43358V109 1,895 1,095,422 SH   DFND 1 0 1,095,422 0
IGNYTA INC COM 451731903 123 143 SH Call DFND 1 0 143 0
IGNYTA INC COM 451731103 825 95,918 SH   DFND 1 0 95,918 0
IMMUNOCELLULAR THERAPEUTICS *W 452536121 113 418,767 SH   DFND 1 0 418,767 0
IMMUNOCELLULAR THERAPEUTICS COM 452536204 445 139,912 SH   DFND 1 0 139,912 0
IMMUNOMEDICS INC COM 452907908 969 1,497 SH Call DFND 1 0 1,497 0
INCYTE CORP COM 45337C952 6,256 468 SH Put DFND 1 0 468 0
INCYTE CORP COM 45337C902 8,969 671 SH Call DFND 1 0 671 0
INOTEK PHARMACEUTICALS COM 45780V102 202 100,930 SH   DFND 1 0 100,930 0
INSMED INC COM 457669907 1,161 663 SH Call DFND 1 0 663 0
INSMED INC COM 457669957 5,360 3,061 SH Put DFND 1 0 3,061 0
INSPIREMD INC COM 45779A804 237 239,335 SH   DFND 1 0 239,335 0
INSPIREMD INC *W 45779A127 258 1,214,925 SH   DFND 1 0 1,214,925 0
INTEC PHARMA LTD SHS M53644106 2,652 514,878 SH   DFND 1 0 514,878 0
INTELLIA THERAPEUTICS INC COM 45826J905 355 252 SH Call DFND 1 0 252 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,973 140,000 SH   DFND 1 0 140,000 0
INTELLIPHARMACEUTICS INTERNATIONAL INC COM 458173101 51 20,412 SH   DFND 1 0 20,412 0
INTRA-CELLULAR THERAPIES INC COM 46116X901 257 158 SH Call DFND 1 0 158 0
IONIS PHARMACEUTICALS INC COM 462222100 4,651 115,694 SH   DFND 1 0 115,694 0
IONIS PHARMACEUTICALS INC COM 462222900 5,270 1,311 SH Call DFND 1 0 1,311 0
IONIS PHARMACEUTICALS INC COM 462222950 10,142 2,523 SH Put DFND 1 0 2,523 0
ISHARES TR ETF 464287955 42,619 3,100 SH Put DFND 1 0 3,100 0
ISHARES TR ETF 464287905 68,740 5,000 SH Call DFND 1 0 5,000 0
JAZZ PHARMACEUTICALS PLC SHS G50871905 4,847 334 SH Call DFND 1 0 334 0
KITE PHARMA INC COM 49803L959 2,284 291 SH Put DFND 1 0 291 0
LA JOLLA PHARMACEUTICAL CO COM 503459904 3,143 1,053 SH Call DFND 1 0 1,053 0
LEXICON PHARMACEUTICALS INC COM 528872302 410 28,626 SH   DFND 1 0 28,626 0
LEXICON PHARMACEUTICALS INC COM 528872952 538 375 SH Put DFND 1 0 375 0
LEXICON PHARMACEUTICALS INC COM 528872902 2,241 1,563 SH Call DFND 1 0 1,563 0
LION BIOTECHNOLOGIES INC COM 53619R902 145 195 SH Call DFND 1 0 195 0
LION BIOTECHNOLOGIES INC COM 53619R102 448 60,156 SH   DFND 1 0 60,156 0
MANNKIND CORP COM 56400P906 167 1,127 SH Call DFND 1 0 1,127 0
MANNKIND CORP COM 56400P706 310 209,292 SH   DFND 1 0 209,292 0
MANNKIND CORP COM 56400P956 3,406 23,014 SH Put DFND 1 0 23,014 0
MEDICINES CO COM 584688905 1,565 320 SH Call DFND 1 0 320 0
MERCK & CO INC COM 58933Y955 21,140 3,327 SH Put DFND 1 0 3,327 0
MERCK & CO INC COM 58933Y905 269,556 42,423 SH Call DFND 1 0 42,423 0
MIRATI THERAPEUTICS INC COM 60468T105 1,299 249,735 SH   DFND 1 0 249,735 0
MIRNA THERAPEUTICS INC COM 60470J103 24 11,054 SH   DFND 1 0 11,054 0
MOLECULIN BIOTECH INC COM 60855D101 117 100,000 SH   DFND 1 0 100,000 0
MONSANTO CO COM 61166W901 3,543 313 SH Call DFND 1 0 313 0
MOTIF BIO PLC *W 619784119 555 411,372 SH   DFND 1 0 411,372 0
MOTIF BIO PLC ADR 619784101 1,574 255,875 SH   DFND 1 0 255,875 0
NEURALSTEM INC COM 64127R951 117 222 SH Put DFND 1 0 222 0
NEURALSTEM INC COM 64127R401 2,720 515,216 SH   DFND 1 0 515,216 0
NEUROMETRIX INC *W 641255153 148 2,947,179 SH   DFND 1 0 2,947,179 0
NEUROMETRIX INC COM 641255500 187 302,104 SH   DFND 1 0 302,104 0
NEWLINK GENETICS CORP COM 651511907 5,820 2,415 SH Call DFND 1 0 2,415 0
NEWLINK GENETICS CORP COM 651511957 6,331 2,627 SH Put DFND 1 0 2,627 0
OASMIA PHARMACEUTICAL AB ADR 67421W109 66 35,054 SH   DFND 1 0 35,054 0
OHR PHARMACEUTICAL INC COM 67778H200 1,253 1,509,315 SH   DFND 1 0 1,509,315 0
ONCOBIOLOGICS INC *W 68235M121 456 930,272 SH   DFND 1 0 930,272 0
ONCOBIOLOGICS INC COM 68235M105 639 238,470 SH   DFND 1 0 238,470 0
ONCOBIOLOGICS INC *W 68235M113 763 930,592 SH   DFND 1 0 930,592 0
ONCONOVA THERAPEUTICS INC *W 68232V116 544 650,750 SH   DFND 1 0 650,750 0
ONCONOVA THERAPEUTICS INC COM 68232V306 1,165 384,360 SH   DFND 1 0 384,360 0
ONCOSEC MEDICAL INC COM 68234L207 1,255 975,839 SH   DFND 1 0 975,839 0
OPGEN INC COM 68373L109 1,235 1,073,894 SH   DFND 1 0 1,073,894 0
OPKO HEALTH INC COM 68375N953 101 126 SH Put DFND 1 0 126 0
OREXIGEN THERAPEUTICS INC COM 686164952 68 197 SH Put DFND 1 0 197 0
OTONOMY INC COM 68906L955 159 130 SH Put DFND 1 0 130 0
OTONOMY INC COM 68906L105 3,416 278,840 SH   DFND 1 0 278,840 0
OVASCIENCE INC COM 69014Q101 792 423,775 SH   DFND 1 0 423,775 0
PALATIN TECHNOLOGIES INC COM 696077403 663 2,025,729 SH   DFND 1 0 2,025,729 0
PARATEK PHARMACEUTICALS INC COM 699374952 1,973 1,025 SH Put DFND 1 0 1,025 0
PARATEK PHARMACEUTICALS INC COM 699374902 2,196 1,141 SH Call DFND 1 0 1,141 0
PARNELL PHARMACEUTICALS HOLDINGS LTD COM Q73622104 181 203,549 SH   DFND 1 0 203,549 0
PORTOLA PHARMACEUTICALS INC COM 737010958 419 107 SH Put DFND 1 0 107 0
PORTOLA PHARMACEUTICALS INC COM 737010908 13,952 3,560 SH Call DFND 1 0 3,560 0
PROTEOSTASIS THERAPEUTICS INC COM 74373B109 467 59,700 SH   DFND 1 0 59,700 0
PROTHENA CORPORATION PLC SHS G72800908 3,682 660 SH Call DFND 1 0 660 0
PSIVIDA CORP COM 74440J101 353 205,100 SH   DFND 1 0 205,100 0
PTC THERAPEUTICS INC COM 69366J900 151 153 SH Call DFND 1 0 153 0
PTC THERAPEUTICS INC COM 69366J200 539 54,736 SH   DFND 1 0 54,736 0
PTC THERAPEUTICS INC COM 69366J950 639 649 SH Put DFND 1 0 649 0
PUMA BIOTECHNOLOGY INC COM 74587V107 394 10,600 SH   DFND 1 0 10,600 0
PUMA BIOTECHNOLOGY INC COM 74587V957 2,329 626 SH Put DFND 1 0 626 0
RADIUS HEALTH INC COM 750469207 998 25,828 SH   DFND 1 0 25,828 0
RADIUS HEALTH INC COM 750469957 1,755 454 SH Put DFND 1 0 454 0
REDHILL BIOPHARMA LTD COM 757468103 1,036 108,014 SH   DFND 1 0 108,014 0
RENNOVA HEALTH INC COM 759757107 45 24,988 SH   DFND 1 0 24,988 0
RENNOVA HEALTH INC *W 759757123 105 5,249,822 SH   DFND 1 0 5,249,822 0
RICEBRAN TECHNOLOGIES COM 762831204 670 779,555 SH   DFND 1 0 779,555 0
ROKA BIOSCIENCE COM 775431208 1,374 389,136 SH   DFND 1 0 389,136 0
RXI PHARMACEUTICALS CORP *W 74979C113 492 2,238,487 SH   DFND 1 0 2,238,487 0
SAGE THERAPEUTICS INC COM 78667J108 240 3,379 SH   DFND 1 0 3,379 0
SAGE THERAPEUTICS INC COM 78667J908 2,047 288 SH Call DFND 1 0 288 0
SAGE THERAPEUTICS INC COM 78667J958 3,283 462 SH Put DFND 1 0 462 0
SANGAMO THERAPEUTICS INC COM 800677956 289 556 SH Put DFND 1 0 556 0
SANGAMO THERAPEUTICS INC COM 800677906 1,816 3,493 SH Call DFND 1 0 3,493 0
SAREPTA THERAPEUTICS INC COM 803607900 11,985 4,049 SH Call DFND 1 0 4,049 0
SEATTLE GENETICS INC COM 812578902 1,521 242 SH Call DFND 1 0 242 0
SEATTLE GENETICS INC COM 812578952 4,337 690 SH Put DFND 1 0 690 0
SELECT SECTOR SPDR TR UNIT 81369Y959 70,255 9,448 SH Put DFND 1 0 9,448 0
SIERRA ONCOLOGY INC COM 82640U107 2,672 1,746,261 SH   DFND 1 0 1,746,261 0
SIGMA LABS INC *W 826598112 250 250,000 SH   DFND 1 0 250,000 0
SIGMA LABS INC COM 826598302 565 182,244 SH   DFND 1 0 182,244 0
SOPHIRIS BIO INC COM 83578Q209 823 290,700 SH   DFND 1 0 290,700 0
SOPHIRIS BIO INC COM 83578Q209 149 52,722 SH   DFND 1 0 52,722 0
SPDR S&P 500 ETF TR ETF 78462F903 141,420 5,999 SH Call DFND 1 0 5,999 0
SPDR S&P 500 ETF TR ETF 78462F953 143,801 6,100 SH Put DFND 1 0 6,100 0
SPDR S&P BIOTECH COM 78464A950 30,426 4,388 SH Put DFND 1 0 4,388 0
SPECTRANETICS CORP COM 84760C107 2,097 72,000 SH   DFND 1 0 72,000 0
SPECTRANETICS CORP COM 84760C957 3,469 1,191 SH Put DFND 1 0 1,191 0
STEMLINE THERAPEUTICS INC COM 85858C957 318 372 SH Put DFND 1 0 372 0
STEMLINE THERAPEUTICS INC COM 85858C907 1,859 2,174 SH Call DFND 1 0 2,174 0
STEMLINE THERAPEUTICS INC COM 85858C107 2,480 290,087 SH   DFND 1 0 290,087 0
STRATA SKIN SCIENCES INC COM 86272A107 428 708,021 SH   DFND 1 0 708,021 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 935 85,000 SH   DFND 1 0 85,000 0
SUNESIS PHARMACEUTICALS INC COM 867328700 632 154,162 SH   DFND 1 0 154,162 0
SUNESIS PHARMACEUTICALS INC COM 867328900 661 1,612 SH Call DFND 1 0 1,612 0
SYNTHETIC BIOLOGICS INC COM 87164U102 892 1,414,211 SH   DFND 1 0 1,414,211 0
TENAX THERAPEUTICS INC COM 88032L100 300 1,163,363 SH   DFND 1 0 1,163,363 0
TESARO INC COM 881569907 3,108 202 SH Call DFND 1 0 202 0
TESARO INC COM 881569957 10,725 697 SH Put DFND 1 0 697 0
TG THERAPEUTICS INC COM 88322Q958 569 488 SH Put DFND 1 0 488 0
TG THERAPEUTICS INC COM 88322Q908 571 490 SH Call DFND 1 0 490 0
THERAPEUTICSMD INC COM 88338N907 180 250 SH Call DFND 1 0 250 0
ULTRAGENYX PHARMACEUTICAL INC COM 90400D958 2,671 394 SH Put DFND 1 0 394 0
UNITED THERAPEUTICS CORP COM 91307C102 2,348 17,342 SH   DFND 1 0 17,342 0
UNITED THERAPEUTICS CORP COM 91307C952 12,171 899 SH Put DFND 1 0 899 0
UNITED THERAPEUTICS CORP COM 91307C902 19,089 1,410 SH Call DFND 1 0 1,410 0
VERICEL INC COM 92346J108 41 14,694 SH   DFND 1 0 14,694 0
VERSARTIS INC COM 92529L902 506 237 SH Call DFND 1 0 237 0
VERTEX PHARMACEUTICALS INC COM 92532F950 5,927 542 SH Put DFND 1 0 542 0
VERTEX PHARMACEUTICALS INC COM 92532F900 15,047 1,376 SH Call DFND 1 0 1,376 0
VISTAGEN THERAPEUTICS INC COM 92840H202 340 173,479 SH   DFND 1 0 173,479 0
VTV THERAPEUTICS INC CL A 918385105 811 123,797 SH   DFND 1 0 123,797 0
WINDTREE THERAPEUTICS INC COM 97382D105 328 287,522 SH   DFND 1 0 287,522 0
WRIGHT MEDICAL GROUP N.V. SHS N96617908 1,665 535 SH Call DFND 1 0 535 0
XENON PHARMACEUTICALS INC. COM 98420N105 1,186 296,478 SH   DFND 1 0 296,478 0
ZAFGEN INC COM 98885E903 69 148 SH Call DFND 1 0 148 0
ZAFGEN INC COM 98885E103 668 143,318 SH   DFND 1 0 143,318 0
ZOGENIX INC COM 98978L204 626 57,700 SH   DFND 1 0 57,700 0
ZOGENIX INC COM 98978L904 885 816 SH Call DFND 1 0 816 0
ZOGENIX INC COM 98978L954 1,303 1,201 SH Put DFND 1 0 1,201 0