The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y909 13,801 2,204 SH Call DFND 1 0 2,204 0
ABBVIE INC COM 00287Y959 7,377 1,178 SH Put DFND 1 0 1,178 0
ACADIA PHARMACEUTICALS INC COM 004225908 18,659 6,470 SH Call DFND 1 0 6,470 0
ACADIA PHARMACEUTICALS INC COM 004225958 1,580 548 SH Put DFND 1 0 548 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 4,166 10,087 SH Call DFND 1 0 10,087 0
ACORDA THERAPEUTICS INC COM 00484M106 4,962 263,947 SH   DFND 1 0 263,947 0
ACORDA THERAPEUTICS INC COM 00484M906 748 398 SH Call DFND 1 0 398 0
ACORDA THERAPEUTICS INC COM 00484M956 11,553 6,145 SH Put DFND 1 0 6,145 0
ACTINIUM PHARMACEUTICALS INC COM 00507W107 760 868,608 SH   DFND 1 0 868,608 0
ACURA PHARMACEUTICALS INC. COM 00509L802 79 103,444 SH   DFND 1 0 103,444 0
ADAMIS PHARMACEUTICALS CORP COM 00547W958 42 134 SH Put DFND 1 0 134 0
ADVAXIS INC COM 007624208 75 10,443 SH   DFND 1 0 10,443 0
ADVAXIS INC COM 007624908 193 270 SH Call DFND 1 0 270 0
ADVAXIS INC COM 007624958 296 414 SH Put DFND 1 0 414 0
ADVERUM BIOTECHNOLOGIES INC. COM 00773U108 822 283,306 SH   DFND 1 0 283,306 0
AETERNA ZENTARIS INC COM 007975402 1,442 400,560 SH   DFND 1 0 400,560 0
AETERNA ZENTARIS INC COM 007975952 221 614 SH Put DFND 1 0 614 0
AEVI GENOMIC MEDICINE INC. COM 00835P105 716 138,195 SH   DFND 1 0 138,195 0
AGENUS INC COM 00847G955 1,031 2,503 SH Put DFND 1 0 2,503 0
AGIOS PHARMACEUTICALS INC COM 00847X904 2,274 545 SH Call DFND 1 0 545 0
AKARI THERAPEUTICS PLC ADR 00972G108 120 17,428 SH   DFND 1 0 17,428 0
ALCOBRA LTD SHS M2239P109 193 91,858 SH   DFND 1 0 91,858 0
ALCOBRA LTD SHS M2239P909 651 3,102 SH Call DFND 1 0 3,102 0
ALCOBRA LTD SHS M2239P959 117 559 SH Put DFND 1 0 559 0
ALEXION PHARMACEUTICALS INC COM 015351909 19,405 1,586 SH Call DFND 1 0 1,586 0
ALKERMES PLC SHS G01767905 9,110 1,639 SH Call DFND 1 0 1,639 0
ALLIQUA BIOMEDICAL INC COM 019621200 649 1,100,398 SH   DFND 1 0 1,100,398 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 518 13,823 SH   DFND 1 0 13,823 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q907 4,643 1,240 SH Call DFND 1 0 1,240 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 7,698 2,056 SH Put DFND 1 0 2,056 0
AMARIN CORPORATION PLC ADR 023111906 3,803 12,346 SH Call DFND 1 0 12,346 0
AMARIN CORPORATION PLC ADR 023111956 344 1,118 SH Put DFND 1 0 1,118 0
AMGEN INC COM 031162100 36,961 252,795 SH   DFND 1 0 252,795 0
AMGEN INC COM 031162900 4,401 301 SH Call DFND 1 0 301 0
AMGEN INC COM 031162950 54,010 3,694 SH Put DFND 1 0 3,694 0
AMICUS THERAPEUTICS INC COM 03152W109 300 60,309 SH   DFND 1 0 60,309 0
AMICUS THERAPEUTICS INC COM 03152W909 5,077 10,216 SH Call DFND 1 0 10,216 0
AMICUS THERAPEUTICS INC COM 03152W959 567 1,140 SH Put DFND 1 0 1,140 0
AMPLIPHI BIOSCIENCES CORP COM 03211P202 668 1,518,814 SH   DFND 1 0 1,518,814 0
ANTHERA PHARMACEUTICALS INC COM 03674U201 59 91,055 SH   DFND 1 0 91,055 0
ANTHERA PHARMACEUTICALS INC COM 03674U901 64 987 SH Call DFND 1 0 987 0
APPLIED DNA SCIENCES *W 03815U110 1,139 2,277,612 SH   DFND 1 0 2,277,612 0
APPLIED DNA SCIENCES COM 03815U201 3,903 2,109,601 SH   DFND 1 0 2,109,601 0
ARBUTUS BIOPHARMA CORP COM 03879J100 1,942 792,617 SH   DFND 1 0 792,617 0
ARBUTUS BIOPHARMA CORP COM 03879J900 498 2,033 SH Call DFND 1 0 2,033 0
ASTERIAS BIOTHERAPEUTICS INC COM 04624N907 92 200 SH Call DFND 1 0 200 0
ASTRAZENECA PLC ADR 004635308 12,985 4,753 SH Call DFND 1 0 4,753 0
ATHERSYS INC COM 04744L106 66 43,263 SH   DFND 1 0 43,263 0
AXOVANT SCIENCES LTD COM G0750W104 1,254 100,998 SH   DFND 1 0 100,998 0
AXOVANT SCIENCES LTD COM G0750W904 7,112 5,726 SH Call DFND 1 0 5,726 0
AXOVANT SCIENCES LTD COM G0750W954 3,276 2,638 SH Put DFND 1 0 2,638 0
AZURRX BIOPHARMA INC. COM 05502L105 564 118,993 SH   DFND 1 0 118,993 0
BARCLAYS BANK PLC IPATH 06740Q260 1,743 50,000 SH   DFND 1 0 50,000 0
BELLEROPHON THERAPEUTICS INC COM 078771102 414 789,857 SH   DFND 1 0 789,857 0
BENITEC BIOPHARMA LTD *W 082053117 10 98,146 SH   DFND 1 0 98,146 0
BENITEC BIOPHARMA LTD ADR 082053307 389 254,445 SH   DFND 1 0 254,445 0
BIO PATH HOLDINGS INC. COM 09057N102 896 664,046 SH   DFND 1 0 664,046 0
BIOBLAST PHARMA LTD SHS M20156101 687 660,157 SH   DFND 1 0 660,157 0
BIOCEPT INC COM 09072V204 319 411,432 SH   DFND 1 0 411,432 0
BIODELIVERY SCIENCES INTL INC. COM 09060J106 1,222 698,235 SH   DFND 1 0 698,235 0
BIOGEN INC COM 09062X103 5,672 20,000 SH   DFND 1 0 20,000 0
BIOGEN INC COM 09062X903 3,261 115 SH Call DFND 1 0 115 0
BIOGEN INC COM 09062X953 2,836 100 SH Put DFND 1 0 100 0
BIOPHARMX CORP COM 09072X101 265 708,046 SH   DFND 1 0 708,046 0
BLUEBIRD BIO INC COM 09609G900 3,665 597 SH Call DFND 1 0 597 0
BLUEPRINT MEDICINES CORP COM 09627Y959 533 190 SH Put DFND 1 0 190 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 637 250,766 SH   DFND 1 0 250,766 0
BRISTOL MYERS SQUIBB CO COM 110122108 16,900 289,183 SH   DFND 1 0 289,183 0
BRISTOL MYERS SQUIBB CO COM 110122908 31,669 5,419 SH Call DFND 1 0 5,419 0
BRISTOL MYERS SQUIBB CO COM 110122958 49,545 8,478 SH Put DFND 1 0 8,478 0
CANCER GENETICS INC COM 13739U104 97 71,971 SH   DFND 1 0 71,971 0
CAPNIA INC COM 14066L105 145 179,002 SH   DFND 1 0 179,002 0
CAPRICOR THERAPEUTICS INC COM 14070B101 990 372,046 SH   DFND 1 0 372,046 0
CARDIOME PHARMA CORP COM 14159U301 1,208 437,720 SH   DFND 1 0 437,720 0
CEL SCI CORP COM 150837508 427 6,360,207 SH   DFND 1 0 6,360,207 0
CELLECT BIOTECHNOLOGY LTD ADS 15116C102 177 57,348 SH   DFND 1 0 57,348 0
CELLECTAR BIOSCIENCES INC *W 15117F120 85 201,889 SH   DFND 1 0 201,889 0
CELLECTAR BIOSCIENCES INC COM 15117F302 395 323,515 SH   DFND 1 0 323,515 0
CELSION CORP COM 15117N404 416 1,333,093 SH   DFND 1 0 1,333,093 0
CEMPRA INC COM 15130J109 121 43,121 SH   DFND 1 0 43,121 0
CHAMPIONS ONCOLOGY INC COM 15870P307 641 253,504 SH   DFND 1 0 253,504 0
CHECK CAP LTD SHS M2361E112 1,352 575,113 SH   DFND 1 0 575,113 0
CHIMERIX INC COM 16934W106 368 79,900 SH   DFND 1 0 79,900 0
CIDARA THERAPEUTICS INC COM 171757107 3,041 292,398 SH   DFND 1 0 292,398 0
CLOVIS ONCOLOGY INC COM 189464900 15,005 3,378 SH Call DFND 1 0 3,378 0
CLOVIS ONCOLOGY INC COM 189464950 1,866 420 SH Put DFND 1 0 420 0
COHERUS BIOSCIENCES INC COM 19249H103 806 28,618 SH   DFND 1 0 28,618 0
COHERUS BIOSCIENCES INC COM 19249H953 2,567 912 SH Put DFND 1 0 912 0
COMBIMATRIX CORP *W 20009T147 363 844,917 SH   DFND 1 0 844,917 0
CYTORI THERAPEUTICS INC *W 23283K121 866 1,273,712 SH   DFND 1 0 1,273,712 0
CYTORI THERAPEUTICS INC COM 23283K204 2,494 1,651,835 SH   DFND 1 0 1,651,835 0
CYTRX CORP COM 232828509 1,749 4,697,802 SH   DFND 1 0 4,697,802 0
DEPOMED INC COM 249908904 335 186 SH Call DFND 1 0 186 0
DEXTERA SURGICAL INC COM 252366109 382 397,863 SH   DFND 1 0 397,863 0
DICERNA PHARMACEUTICALS INC COM 253031108 288 100,000 SH   DFND 1 0 100,000 0
DURECT CORP COM 266605104 2,048 1,528,516 SH   DFND 1 0 1,528,516 0
DURECT CORP COM 266605904 928 6,927 SH Call DFND 1 0 6,927 0
DYNAVAX TECHNOLOGIES CORP COM 268158201 261 66,091 SH   DFND 1 0 66,091 0
DYNAVAX TECHNOLOGIES CORP COM 268158901 782 1,979 SH Call DFND 1 0 1,979 0
DYNAVAX TECHNOLOGIES CORP COM 268158951 102 258 SH Put DFND 1 0 258 0
EDAP TMS S A ADR 268311107 76 22,993 SH   DFND 1 0 22,993 0
EDAP TMS S A ADR 268311957 112 341 SH Put DFND 1 0 341 0
EDITAS MEDICINE INC. COM 28106W103 1,866 115,000 SH   DFND 1 0 115,000 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,802 240,541 SH   DFND 1 0 240,541 0
ELI LILLY & CO COM 532457108 15,674 213,113 SH   DFND 1 0 213,113 0
ELI LILLY & CO COM 532457908 174,130 23,675 SH Call DFND 1 0 23,675 0
ELI LILLY & CO COM 532457958 29,736 4,043 SH Put DFND 1 0 4,043 0
ENDO INTERNATIONAL PLC SHS G30401106 2,078 126,139 SH   DFND 1 0 126,139 0
ENDO INTERNATIONAL PLC SHS G30401956 2,179 1,323 SH Put DFND 1 0 1,323 0
ENTEROMEDICS INC COM 29365M505 67 33,387 SH   DFND 1 0 33,387 0
EXELIXIS INC COM 30161Q904 2,658 1,783 SH Call DFND 1 0 1,783 0
EXELIXIS INC COM 30161Q954 8,039 5,392 SH Put DFND 1 0 5,392 0
EXPRESS SCRIPTS HOLDING CO COM 30219G108 1,616 23,494 SH   DFND 1 0 23,494 0
EXPRESS SCRIPTS HOLDING CO COM 30219G908 19,928 2,897 SH Call DFND 1 0 2,897 0
EXPRESS SCRIPTS HOLDING CO COM 30219G958 8,193 1,191 SH Put DFND 1 0 1,191 0
EYEGATE PHARMACEUTICALS INC COM 30233M107 314 192,721 SH   DFND 1 0 192,721 0
EYEGATE PHARMACEUTICALS INC *W 30233M115 6 20,604 SH   DFND 1 0 20,604 0
FIBROGEN INC COM 31572Q908 2,544 1,189 SH Call DFND 1 0 1,189 0
FLEXION THERAPEUTICS INC COM 33938J106 208 10,914 SH   DFND 1 0 10,914 0
FLEXION THERAPEUTICS INC COM 33938J906 240 126 SH Call DFND 1 0 126 0
FLEXION THERAPEUTICS INC COM 33938J956 472 248 SH Put DFND 1 0 248 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 648 58,338 SH   DFND 1 0 58,338 0
FOAMIX PHARMACEUTICALS LTD SHS M46135905 978 881 SH Call DFND 1 0 881 0
FORWARD PHARMA A/S ADR 34986J105 1,565 104,273 SH   DFND 1 0 104,273 0
GALECTIN THERAPEUTICS INC COM 363225952 23 235 SH Put DFND 1 0 235 0
GALENA BIOPHARMA INC COM 363256504 45 23,298 SH   DFND 1 0 23,298 0
GALENA BIOPHARMA INC COM 363256954 164 847 SH Put DFND 1 0 847 0
GENETIC TECHNOLOGIES LTD SHS 37185R208 1,156 1,070,333 SH   DFND 1 0 1,070,333 0
GENVEC INC COM 37246C406 387 120,544 SH   DFND 1 0 120,544 0
GILEAD SCIENCES INC COM 375558903 30,914 4,317 SH Call DFND 1 0 4,317 0
GREAT PANTHER SILVER LTD COM 39115V951 45 269 SH Put DFND 1 0 269 0
GW PHARMACEUTICALS PLC ADS 36197T903 2,615 234 SH Call DFND 1 0 234 0
GW PHARMACEUTICALS PLC ADS 36197T953 2,146 192 SH Put DFND 1 0 192 0
HALOZYME THERAPEUTICS INC COM 40637H909 2,676 2,708 SH Call DFND 1 0 2,708 0
HALOZYME THERAPEUTICS INC COM 40637H959 526 532 SH Put DFND 1 0 532 0
HCA HOLDINGS INC COM 40412C901 48,046 6,491 SH Call DFND 1 0 6,491 0
HCA HOLDINGS INC COM 40412C951 740 100 SH Put DFND 1 0 100 0
HEMISPHERX BIOPHARMA INC COM 42366C301 960 1,391,286 SH   DFND 1 0 1,391,286 0
HERON THERAPEUTICS INC COM 427746902 185 141 SH Call DFND 1 0 141 0
HESS CORP COM 42809H907 5,619 902 SH Call DFND 1 0 902 0
HISTOGENICS CORP COM 43358V109 1,578 944,891 SH   DFND 1 0 944,891 0
HORIZON PHARMA PLC SHS G4617B905 9,647 5,962 SH Call DFND 1 0 5,962 0
HORIZON PHARMA PLC SHS G4617B955 4,516 2,791 SH Put DFND 1 0 2,791 0
HUMANA INC COM 444859902 5,937 291 SH Call DFND 1 0 291 0
IGNYTA INC COM 451731103 1,034 195,000 SH   DFND 1 0 195,000 0
IMMUNOCELLULAR THERAPEUTICS *W 452536121 192 383,471 SH   DFND 1 0 383,471 0
IMMUNOCELLULAR THERAPEUTICS COM 452536204 328 160,129 SH   DFND 1 0 160,129 0
IMMUNOMEDICS INC COM 452907108 184 50,000 SH   DFND 1 0 50,000 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 921 150,930 SH   DFND 1 0 150,930 0
INOTEK PHARMACEUTICALS CORP COM 45780V902 65 106 SH Call DFND 1 0 106 0
INOTEK PHARMACEUTICALS CORP COM 45780V952 305 500 SH Put DFND 1 0 500 0
INSMED INC COM 457669307 636 48,043 SH   DFND 1 0 48,043 0
INSMED INC COM 457669907 1,930 1,459 SH Call DFND 1 0 1,459 0
INSMED INC COM 457669957 2,531 1,913 SH Put DFND 1 0 1,913 0
INSPIREMD INC *W 45779A127 726 1,210,106 SH   DFND 1 0 1,210,106 0
INTEC PHARMA LTD SHS M53644106 2,930 514,100 SH   DFND 1 0 514,100 0
INTELLIA THERAPEUTICS INC COM 45826J105 1,704 130,000 SH   DFND 1 0 130,000 0
INTRA-CELLULAR THERAPIES INC COM 46116X901 2,688 1,781 SH Call DFND 1 0 1,781 0
IONIS PHARMACEUTICALS INC COM 462222900 5,041 1,054 SH Call DFND 1 0 1,054 0
IONIS PHARMACEUTICALS INC COM 462222950 3,525 737 SH Put DFND 1 0 737 0
ISHARES TR ETF 464287955 100,045 7,419 SH Put DFND 1 0 7,419 0
JUNO THERAPEUTICS INC COM 48205A909 194 103 SH Call DFND 1 0 103 0
KITE PHARMA INC COM 49803L909 5,251 1,171 SH Call DFND 1 0 1,171 0
KITE PHARMA INC COM 49803L959 1,305 291 SH Put DFND 1 0 291 0
LA JOLLA PHARMACEUTICAL CO COM 503459604 3,698 210,978 SH   DFND 1 0 210,978 0
LA JOLLA PHARMACEUTICAL CO COM 503459904 2,957 1,687 SH Call DFND 1 0 1,687 0
LA JOLLA PHARMACEUTICAL CO COM 503459954 589 336 SH Put DFND 1 0 336 0
LEXICON PHARMACEUTICALS INC COM 528872302 969 70,040 SH   DFND 1 0 70,040 0
LEXICON PHARMACEUTICALS INC COM 528872902 2,162 1,563 SH Call DFND 1 0 1,563 0
LEXICON PHARMACEUTICALS INC COM 528872952 167 121 SH Put DFND 1 0 121 0
LION BIOTECHNOLOGIES INC COM 53619R102 1,571 226,081 SH   DFND 1 0 226,081 0
LION BIOTECHNOLOGIES INC COM 53619R952 876 1,260 SH Put DFND 1 0 1,260 0
LION BIOTECHNOLOGIES INC COM 53619R990 136 195 SH Call DFND 1 0 195 0
MANNKIND CORP COM 56400P951 499 7,842 SH Put DFND 1 0 7,842 0
MEDICINES CO COM 584688105 3,815 112,392 SH   DFND 1 0 112,392 0
MEDICINES CO COM 584688905 1,551 457 SH Call DFND 1 0 457 0
MEDICINES CO COM 584688955 3,978 1,172 SH Put DFND 1 0 1,172 0
MEDIGUS LTD ADR 58471G102 50 87,876 SH   DFND 1 0 87,876 0
MERCK & CO COM 58933Y905 74,459 12,648 SH Call DFND 1 0 12,648 0
MIRATI THERAPEUTICS INC COM 60468T105 474 99,735 SH   DFND 1 0 99,735 0
MIRNA THERAPEUTICS INC COM 60470J103 180 100,200 SH   DFND 1 0 100,200 0
MONSANTO CO COM 61166W901 3,293 313 SH Call DFND 1 0 313 0
MOTIF BIO PLC COM 619784101 5,121 847,826 SH   DFND 1 0 847,826 0
MOTIF BIO PLC *W 619784119 550 426,170 SH   DFND 1 0 426,170 0
MYLAN N.V. SHS N59465909 15,878 4,162 SH Call DFND 1 0 4,162 0
NEKTAR THERAPEUTICS COM 640268908 135 110 SH Call DFND 1 0 110 0
NEURALSTEM INC COM 64127R302 63 229,521 SH   DFND 1 0 229,521 0
NEUROCRINE BIOSCIENCES INC COM 64125C909 4,462 1,153 SH Call DFND 1 0 1,153 0
NEURODERM LTD SHS M74231107 511 23,033 SH   DFND 1 0 23,033 0
NEUROMETRIX INC *W 641255153 211 3,017,747 SH   DFND 1 0 3,017,747 0
NEUROMETRIX INC COM 641255500 123 166,268 SH   DFND 1 0 166,268 0
NEVRO CORP COM 64157F903 1,199 165 SH Call DFND 1 0 165 0
NEWLINK GENETICS CORP COM 651511107 579 56,289 SH   DFND 1 0 56,289 0
NEWLINK GENETICS CORP COM 651511907 1,624 1,580 SH Call DFND 1 0 1,580 0
NIVALIS THERAPEUTICS INC COM 65481J109 90 40,004 SH   DFND 1 0 40,004 0
NOVAVAX INC COM 670002904 20 159 SH Call DFND 1 0 159 0
OCERA THERAPEUTICS INC COM 67552A108 690 328,632 SH   DFND 1 0 328,632 0
OHR PHARMACEUTICAL INC COM 67778H200 1,735 1,156,393 SH   DFND 1 0 1,156,393 0
ONCOBIOLOGICS INC COM 68235M105 6,738 2,238,470 SH   DFND 1 0 2,238,470 0
ONCOBIOLOGICS INC *W 68235M113 154 930,592 SH   DFND 1 0 930,592 0
ONCOBIOLOGICS INC *W 68235M121 726 930,272 SH   DFND 1 0 930,272 0
ONCONOVA THERAPEUTICS INC *W 68232V116 428 691,072 SH   DFND 1 0 691,072 0
ONCONOVA THERAPEUTICS INC COM 68232V306 1,028 452,804 SH   DFND 1 0 452,804 0
ONCOSEC MEDICAL INC COM 68234L207 1,444 1,173,946 SH   DFND 1 0 1,173,946 0
OPGEN INC COM 68373L109 604 525,146 SH   DFND 1 0 525,146 0
OPHTHOTECH CORP COM 683745903 426 883 SH Call DFND 1 0 883 0
OPKO HEALTH INC COM 68375N103 1,776 190,955 SH   DFND 1 0 190,955 0
OPKO HEALTH INC COM 68375N903 1,387 1,491 SH Call DFND 1 0 1,491 0
OPKO HEALTH INC COM 68375N953 2,116 2,275 SH Put DFND 1 0 2,275 0
OTONOMY ORD SHS COM 68906L105 159 10,000 SH   DFND 1 0 10,000 0
OVASCIENCE INC COM 69014Q101 74 48,450 SH   DFND 1 0 48,450 0
PACIRA PHARMACEUTICALS INC COM 695127900 2,261 700 SH Call DFND 1 0 700 0
PACIRA PHARMACEUTICALS INC COM 695127950 514 159 SH Put DFND 1 0 159 0
PALATIN TECHNOLOGIES INC COM 696077403 853 1,672,573 SH   DFND 1 0 1,672,573 0
PARATEK PHARMACEUTICALS INC COM 699374302 1,694 110,000 SH   DFND 1 0 110,000 0
PARNELL PHARMACEUTICALS HOLDINGS LTD COM Q73622104 138 200,549 SH   DFND 1 0 200,549 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,814 1,296,034 SH   DFND 1 0 1,296,034 0
PORTOLA PHARMACEUTICALS INC COM 737010908 4,046 1,803 SH Call DFND 1 0 1,803 0
PORTOLA PHARMACEUTICALS INC COM 737010958 240 107 SH Put DFND 1 0 107 0
PRONAI THERAPEUTICS INC. COM 74346L101 1,402 940,841 SH   DFND 1 0 940,841 0
PROQR THERAPEUTICS N V SHS N71542109 196 40,000 SH   DFND 1 0 40,000 0
PROTHENA CORPORATION PLC COM G72800908 2,410 490 SH Call DFND 1 0 490 0
PSIVIDA CORP COM 74440J101 351 205,100 SH   DFND 1 0 205,100 0
PTC THERAPEUTICS INC COM 69366J900 6,481 5,940 SH Call DFND 1 0 5,940 0
PTC THERAPEUTICS INC COM 69366J950 651 597 SH Put DFND 1 0 597 0
PUMA BIOTECHNOLOGY INC COM 74587V107 3,170 103,243 SH   DFND 1 0 103,243 0
PUMA BIOTECHNOLOGY INC COM 74587V907 6,683 2,177 SH Call DFND 1 0 2,177 0
PUMA BIOTECHNOLOGY INC COM 74587V957 5,216 1,699 SH Put DFND 1 0 1,699 0
RADIUS HEALTH INC COM 750469957 4,526 1,190 SH Put DFND 1 0 1,190 0
REDHILL BIOPHARMA LTD ADS 757468103 2,006 191,785 SH   DFND 1 0 191,785 0
REGENERON PHARMACEUTICALS INC COM 75886F107 59,658 162,517 SH   DFND 1 0 162,517 0
REGENERON PHARMACEUTICALS INC COM 75886F907 7,415 202 SH Call DFND 1 0 202 0
REGENERON PHARMACEUTICALS INC COM 75886F957 80,686 2,198 SH Put DFND 1 0 2,198 0
REGENXBIO INC COM 75901B107 898 48,400 SH   DFND 1 0 48,400 0
RENNOVA HEALTH INC COM 759757107 167 2,022,213 SH   DFND 1 0 2,022,213 0
RENNOVA HEALTH INC *W 759757123 118 4,926,013 SH   DFND 1 0 4,926,013 0
RETROPHIN INC COM 761299906 9,083 4,798 SH Call DFND 1 0 4,798 0
RETROPHIN INC COM 761299956 772 408 SH Put DFND 1 0 408 0
REXAHN PHARMACEUTICALS INC COM 761640101 1,040 7,326,681 SH   DFND 1 0 7,326,681 0
RICEBRAN TECHNOLOGIES COM 762831204 902 875,286 SH   DFND 1 0 875,286 0
RIGEL PHARMACEUTICALS INC COM 766559603 29 12,350 SH   DFND 1 0 12,350 0
ROKA BIOSCIENCE INC COM 775431208 1,549 365,220 SH   DFND 1 0 365,220 0
ROSETTA GENOMICS LTD SHS M82183126 248 591,339 SH   DFND 1 0 591,339 0
RXI PHARMACEUTICALS CORP *W 74979C113 454 2,270,283 SH   DFND 1 0 2,270,283 0
RXI PHARMACEUTICALS CORP COM 74979C501 284 397,371 SH   DFND 1 0 397,371 0
SAGE THERAPEUTICS INC COM 78667J908 4,335 849 SH Call DFND 1 0 849 0
SAGE THERAPEUTICS INC COM 78667J958 521 102 SH Put DFND 1 0 102 0
SANGAMO BIOSCIENCES INC COM 800677106 193 63,204 SH   DFND 1 0 63,204 0
SANGAMO BIOSCIENCES INC COM 800677906 1,884 6,177 SH Call DFND 1 0 6,177 0
SAREPTA THERAPEUTICS INC COM 803607100 55,266 2,014,787 SH   DFND 1 0 2,014,787 0
SAREPTA THERAPEUTICS INC COM 803607900 1,676 611 SH Call DFND 1 0 611 0
SAREPTA THERAPEUTICS INC COM 803607950 52,805 19,251 SH Put DFND 1 0 19,251 0
SIENTRA INC COM 82621J105 605 70,973 SH   DFND 1 0 70,973 0
SIENTRA INC COM 82621J955 2,056 2,413 SH Put DFND 1 0 2,413 0
SOPHIRIS BIO INC COM 83578Q209 1,391 496,729 SH   DFND 1 0 496,729 0
SPDR S&P 500 ETF TR ETF 78462F953 134,118 6,000 SH Put DFND 1 0 6,000 0
SPDR S&P BIOTECH ETF ETF 78464A870 693 11,700 SH   DFND 1 0 11,700 0
SPDR S&P BIOTECH ETF ETF 78464A950 27,364 4,623 SH Put DFND 1 0 4,623 0
STEMLINE THERAPEUTICS INC COM 85858C107 3,829 357,806 SH   DFND 1 0 357,806 0
STEMLINE THERAPEUTICS INC COM 85858C907 381 356 SH Call DFND 1 0 356 0
STRATA SKIN SCIENCES INC COM 86272A107 455 1,034,820 SH   DFND 1 0 1,034,820 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 1,016 75,000 SH   DFND 1 0 75,000 0
SUNESIS PHARMACEUTICALS INC COM 867328700 801 221,326 SH   DFND 1 0 221,326 0
SUPERCONDUCTOR TECHNOLOGIES COM 867931503 535 434,747 SH   DFND 1 0 434,747 0
SYNERGY PHARMACEUTICALS INC COM 871639908 4,589 7,536 SH Call DFND 1 0 7,536 0
SYNTHETIC BIOLOGICS INC COM 87164U102 2,312 3,031,953 SH   DFND 1 0 3,031,953 0
TENAX THERAPEUTICS INC COM 88032L100 2,958 1,516,835 SH   DFND 1 0 1,516,835 0
TENAX THERAPEUTICS INC COM 88032L900 2,386 12,237 SH Call DFND 1 0 12,237 0
TENAX THERAPEUTICS INC COM 88032L950 33 169 SH Put DFND 1 0 169 0
TESARO INC COM 881569907 25,094 1,866 SH Call DFND 1 0 1,866 0
TESARO INC COM 881569957 7,571 563 SH Put DFND 1 0 563 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR 881624909 31,313 8,638 SH Call DFND 1 0 8,638 0
TG THERAPEUTICS INC COM 88322Q958 394 848 SH Put DFND 1 0 848 0
THERAPEUTICSMD INC COM 88338N107 144 24,955 SH   DFND 1 0 24,955 0
THERAPEUTICSMD INC COM 88338N907 406 703 SH Call DFND 1 0 703 0
THERAPEUTICSMD INC COM 88338N957 338 586 SH Put DFND 1 0 586 0
UNITED THERAPEUTICS CORP COM 91307C902 3,772 263 SH Call DFND 1 0 263 0
UNITED THERAPEUTICS CORP COM 91307C952 15,777 1,100 SH Put DFND 1 0 1,100 0
VANDA PHARMACEUTICALS INC COM 921659908 802 503 SH Call DFND 1 0 503 0
VERACYTE INC COM 92337F107 1,502 193,999 SH   DFND 1 0 193,999 0
VERICEL INC COM 92346J108 450 149,900 SH   DFND 1 0 149,900 0
VERTEX PHARMACEUTICALS INC COM 92532F900 7,883 1,070 SH Call DFND 1 0 1,070 0
VERTEX PHARMACEUTICALS INC COM 92532F950 2,181 296 SH Put DFND 1 0 296 0
VIKING THERAPEUTICS INC *W 92686J114 39 86,349 SH   DFND 1 0 86,349 0
VISTAGEN THERAPEUTICS INC COM 92840H202 658 176,384 SH   DFND 1 0 176,384 0
VTV THERAPEUTICS INC CL A 918385105 640 132,547 SH   DFND 1 0 132,547 0
WAFERGEN BIO SYSTEMS INC COM 93041P506 1,771 358,535 SH   DFND 1 0 358,535 0
WINDTREE THERAPEUTICS INC COM 97382D105 415 334,414 SH   DFND 1 0 334,414 0
XTL BIOPHARMACEUTICALS LTD ADR 98386D208 434 724,134 SH   DFND 1 0 724,134 0
ZAFGEN INC. COM 98885E103 986 310,000 SH   DFND 1 0 310,000 0
ZOGENIX INC COM 98978L904 15,025 12,366 SH Call DFND 1 0 12,366 0
ZOGENIX INC COM 98978L954 165 136 SH Put DFND 1 0 136 0
ZOSANO PHARMA ORD SHS COM 98979H103 81 103,600 SH   DFND 1 0 103,600 0