The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824900 2,182 555 SH Call DFND 1 0 555 0
ABBOTT LABS COM 002824100 10,405 264,700 SH   DFND 1 0 264,700 0
ABBOTT LABS COM 002824950 19,655 5,000 SH Put DFND 1 0 5,000 0
ABBVIE INC COM 00287Y959 14,530 2,347 SH Put DFND 1 0 2,347 0
ABBVIE INC COM 00287Y909 111,481 18,007 SH Call DFND 1 0 18,007 0
ABEONA THERAPEUTICS ORD SHS COM 00289Y107 637 270,000 SH   DFND 1 0 270,000 0
ACADIA PHARMACEUTICALS INC COM 004225958 1,607 495 SH Put DFND 1 0 495 0
ACADIA PHARMACEUTICALS INC COM 004225908 15,172 4,674 SH Call DFND 1 0 4,674 0
ACHILLION PHARMACEUTICALS INC COM 00448Q951 780 1,000 SH Put DFND 1 0 1,000 0
ACHILLION PHARMACEUTICALS INC COM 00448Q901 2,985 3,827 SH Call DFND 1 0 3,827 0
ACLARIS THERAPEUTICS INC COM 00461U105 292 15,812 SH   DFND 1 0 15,812 0
ACORDA THERAPEUTICS INC COM 00484M956 255 100 SH Put DFND 1 0 100 0
ACORDA THERAPEUTICS INC 1.75% NOTE 00484MAA4 8,388 9,600,000 PRN   DFND 1 0 9,600,000 0
ACURA PHARMACEUTICALS INC COM 00509L802 959 518,444 SH   DFND 1 0 518,444 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 1,478 97,600 SH   DFND 1 0 97,600 0
ADMA BIOLOGICS INC COM 000899104 595 100,000 SH   DFND 1 0 100,000 0
ADURO BIOTECH INC COM 00739L901 1,495 1,322 SH Call DFND 1 0 1,322 0
ADVAXIS INC COM 007624958 113 140 SH Put DFND 1 0 140 0
ADVAXIS INC COM 007624208 113 14,000 SH   DFND 1 0 14,000 0
ADVERUM BIOTECHNOLOGIES INC. COM 00773U108 2,465 779,926 SH   DFND 1 0 779,926 0
AERIE PHARMACEUTICALS INC COM 00771V908 1,186 674 SH Call DFND 1 0 674 0
AETERNA ZENTARIS INC COM 007975402 867 265,803 SH   DFND 1 0 265,803 0
AKARI THERAPEUTICS PLC ADR 00972G108 235 17,428 SH   DFND 1 0 17,428 0
AKEBIA THERAPEUTICS INC COM 00972D105 75 100 SH Call DFND 1 0 100 0
ALCOBRA LTD SHS M2239P109 82 18,317 SH   DFND 1 0 18,317 0
ALCOBRA LTD SHS M2239P959 184 409 SH Put DFND 1 0 409 0
ALCOBRA LTD SHS M2239P909 2,006 4,467 SH Call DFND 1 0 4,467 0
ALKERMES PLC SHS G01767905 7,930 1,335 SH Call DFND 1 0 1,335 0
ALLIQUA BIOMEDICAL INC COM 019621900 54 483 SH Call DFND 1 0 483 0
ALLIQUA BIOMEDICAL INC COM 019621200 1,680 1,500,000 SH   DFND 1 0 1,500,000 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q957 3,363 606 SH Put DFND 1 0 606 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q907 5,477 987 SH Call DFND 1 0 987 0
AMARIN CORPORATION PLC ADR 023111956 241 1,118 SH Put DFND 1 0 1,118 0
AMARIN CORPORATION PLC ADR 023111906 2,033 9,411 SH Call DFND 1 0 9,411 0
AMGEN INC COM 031162100 23,444 154,082 SH   DFND 1 0 154,082 0
AMGEN INC COM 031162950 59,978 3,942 SH Put DFND 1 0 3,942 0
AMICUS THERAPEUTICS INC COM 03152W109 687 125,912 SH   DFND 1 0 125,912 0
AMICUS THERAPEUTICS INC COM 03152W959 1,220 2,234 SH Put DFND 1 0 2,234 0
AMICUS THERAPEUTICS INC COM 03152W909 4,364 7,992 SH Call DFND 1 0 7,992 0
AMPLIPHI BIOSCIENCES CORP COM 03211P202 951 613,782 SH   DFND 1 0 613,782 0
ANTARES PHARMA INC COM 036642106 445 424,100 SH   DFND 1 0 424,100 0
ANTHERA PHARMACEUTICALS INC COM 03674U201 309 100,000 SH   DFND 1 0 100,000 0
ANTHERA PHARMACEUTICALS INC COM 03674U901 518 1,677 SH Call DFND 1 0 1,677 0
ARALEZ PHARMACEUTICALS INC COM 03852X900 136 413 SH Call DFND 1 0 413 0
ARALEZ PHARMACEUTICALS INC COM 03852X100 754 228,364 SH   DFND 1 0 228,364 0
ARBUTUS BIOPHARMA CORP COM 03879J900 233 669 SH Call DFND 1 0 669 0
ARBUTUS BIOPHARMA CORP COM 03879J100 4,093 1,176,031 SH   DFND 1 0 1,176,031 0
ASSEMBLY BIOSCIENCES INC COM 045396108 502 90,362 SH   DFND 1 0 90,362 0
ASTERIAS BIOTHERAPEUTICS INC COM 04624N107 741 308,909 SH   DFND 1 0 308,909 0
ATHERSYS INC SHS COM 04744L956 49 225 SH Put DFND 1 0 225 0
ATHERSYS INC SHS COM 04744L106 199 91,746 SH   DFND 1 0 91,746 0
AXOVANT SCIENCES LTD COM G0750W104 2,440 190,000 SH   DFND 1 0 190,000 0
BARCLAYS BANK IPATH S&P 500 MT ETN 06740C519 2,805 260,000 SH   DFND 1 0 260,000 0
BENITEC BIOPHARMA LTD ADR 082053307 438 345,576 SH   DFND 1 0 345,576 0
BENITEC BIOPHARMA LTD *W 082053117 24 98,146 SH   DFND 1 0 98,146 0
BIO BLAST PHARMA LTD SHS M20156101 1,328 830,253 SH   DFND 1 0 830,253 0
BIO PATH HOLDINGS INC COM 09057N102 5,947 2,988,295 SH   DFND 1 0 2,988,295 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J906 384 1,626 SH Call DFND 1 0 1,626 0
BIODELIVERY SCIENCES INTERNATIONAL INC COM 09060J106 1,854 785,799 SH   DFND 1 0 785,799 0
BIOGEN INC COM 09062X953 2,418 100 SH Put DFND 1 0 100 0
BIOGEN INC COM 09062X103 2,418 10,000 SH   DFND 1 0 10,000 0
BIOGEN INC COM 09062X903 45,124 1,866 SH Call DFND 1 0 1,866 0
BIOPHARMX CORP COM 09072X101 622 957,000 SH   DFND 1 0 957,000 0
BRAINSTORM CELL THERAPEUTICS INC COM 10501E201 1,149 476,719 SH   DFND 1 0 476,719 0
CANCER GENETICS INC COM 13739U104 397 199,580 SH   DFND 1 0 199,580 0
CAPNIA INC. COM 14066L105 581 501,240 SH   DFND 1 0 501,240 0
CAPRICOR THERAPEUTICS INC COM 14070B101 719 182,083 SH   DFND 1 0 182,083 0
CAPSTONE TURBINE CORP COM 14067D409 1,845 1,336,901 SH   DFND 1 0 1,336,901 0
CASCADIAN THERAPEUTICS INC COM 14740B101 815 864,402 SH   DFND 1 0 864,402 0
CEL SCI CORP COM 150837508 3,755 8,163,816 SH   DFND 1 0 8,163,816 0
CELATOR PHARMACEUTICALS INC COM 15089R102 800 26,500 SH   DFND 1 0 26,500 0
CELGENE CORP COM 151020954 759 77 SH Put DFND 1 0 77 0
CELGENE CORP COM 151020904 6,855 695 SH Call DFND 1 0 695 0
CELLECTAR BIOSCIENCES INC *W 15117F120 219 230,013 SH   DFND 1 0 230,013 0
CELSION CORP. COM 15117N404 1,930 1,519,365 SH   DFND 1 0 1,519,365 0
CEMPRA INC COM 15130J109 1,056 64,065 SH   DFND 1 0 64,065 0
CEMPRA INC COM 15130J909 2,535 1,537 SH Call DFND 1 0 1,537 0
CEMPRA INC COM 15130J959 3,859 2,340 SH Put DFND 1 0 2,340 0
CHAMPIONS ONCOLOGY INC COM 15870P307 1,175 546,728 SH   DFND 1 0 546,728 0
CIDARA THERAPEUTICS INC COM 171757107 209 20,277 SH   DFND 1 0 20,277 0
CLOVIS ONCOLOGY INC COM 189464950 141 103 SH Put DFND 1 0 103 0
CLOVIS ONCOLOGY INC COM 189464100 821 59,836 SH   DFND 1 0 59,836 0
CLOVIS ONCOLOGY INC COM 189464900 2,231 1,626 SH Call DFND 1 0 1,626 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 1,202 101,410 SH   DFND 1 0 101,410 0
COMBIMATRIX CORP. COM 20009T501 41 14,391 SH   DFND 1 0 14,391 0
COMBIMATRIX CORP. *W 20009T147 573 855,171 SH   DFND 1 0 855,171 0
CORSICANTO LTD 3.5% NOTE 220480AB3 7,877 7,756,000 PRN   DFND 1 0 7,756,000 0
CYNAPSUS THERAPEUTICS INC COM 23257Y859 305 18,194 SH   DFND 1 0 18,194 0
CYTORI THERAPEUTICS INC *W 23283K121 793 1,004,065 SH   DFND 1 0 1,004,065 0
CYTORI THERAPEUTICS INC COM 23283K204 4,110 1,966,708 SH   DFND 1 0 1,966,708 0
DEPOMED INC COM 249908904 1,546 788 SH Call DFND 1 0 788 0
DERMIRA INC COM 24983L104 781 26,693 SH   DFND 1 0 26,693 0
DERMIRA INC COM 24983L954 845 289 SH Put DFND 1 0 289 0
DERMIRA INC COM 24983L904 1,205 412 SH Call DFND 1 0 412 0
DEXCOM INC COM 252131907 9,361 1,180 SH Call DFND 1 0 1,180 0
DEXCOM INC COM 252131957 33,430 4,214 SH Put DFND 1 0 4,214 0
DEXTERA SURGICAL INC. COM 252366109 868 482,000 SH   DFND 1 0 482,000 0
DURECT CORP COM 266605904 94 770 SH Call DFND 1 0 770 0
DURECT CORP COM 266605104 3,099 2,540,278 SH   DFND 1 0 2,540,278 0
DYNAVAX TECHNOLOGIES CORP COM 268158201 4,236 290,505 SH   DFND 1 0 290,505 0
DYNAVAX TECHNOLOGIES CORP COM 268158951 8,663 5,942 SH Put DFND 1 0 5,942 0
DYNAVAX TECHNOLOGIES CORP COM 268158901 15,618 10,712 SH Call DFND 1 0 10,712 0
EDAP TMS S A ADR 268311957 52 157 SH Put DFND 1 0 157 0
EDAP TMS S A ADR 268311107 2,804 847,225 SH   DFND 1 0 847,225 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 3,473 175,249 SH   DFND 1 0 175,249 0
ELI LILLY & CO COM 532457958 38,517 4,891 SH Put DFND 1 0 4,891 0
ELI LILLY & CO COM 532457908 237,203 30,121 SH Call DFND 1 0 30,121 0
ENDO INTERNATIONAL PLC SHS G30401106 936 60,061 SH   DFND 1 0 60,061 0
EXELIXIS INC COM 30161Q904 1,393 1,783 SH Call DFND 1 0 1,783 0
EXPRESS SCRIPTS HOLDING CO. COM 30219E103 1,242 16,386 SH   DFND 1 0 16,386 0
EXPRESS SCRIPTS HOLDING CO. COM 30219E953 5,041 665 SH Put DFND 1 0 665 0
EYEGATE PHARMACEUTICALS INC *W 30233M115 2 53,893 SH   DFND 1 0 53,893 0
EYEGATE PHARMACEUTICALS INC COM 30233M107 1,002 386,940 SH   DFND 1 0 386,940 0
FIBROGEN INC COM 31572Q808 1,596 97,274 SH   DFND 1 0 97,274 0
FLEXION THERAPEUTICS INC COM 33938J106 1,508 100,800 SH   DFND 1 0 100,800 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,611 253,706 SH   DFND 1 0 253,706 0
FORWARD PHARMA A/S ADR 34986J105 1,856 102,135 SH   DFND 1 0 102,135 0
GALECTIN THERAPEUTICS INC COM 363225202 974 662,467 SH   DFND 1 0 662,467 0
GALENA BIOPHARMA INC COM 363256108 53 113,530 SH   DFND 1 0 113,530 0
GALENA BIOPHARMA INC COM 363256958 107 2,289 SH Put DFND 1 0 2,289 0
GENVEC INC COM 37246C307 931 1,625,435 SH   DFND 1 0 1,625,435 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U908 698 421 SH Call DFND 1 0 421 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 4,214 254,029 SH   DFND 1 0 254,029 0
GW PHARMACEUTICALS PLC COM 36197T903 1,575 172 SH Call DFND 1 0 172 0
HALOZYME THERAPEUTICS INC COM 40637H909 1,813 2,101 SH Call DFND 1 0 2,101 0
HCA HOLDINGS INC COM 40412C951 770 100 SH Put DFND 1 0 100 0
HCA HOLDINGS INC COM 40412C901 71,550 9,291 SH Call DFND 1 0 9,291 0
HEARTWARE INTERNATIONAL INC COM 422368950 514 89 SH Put DFND 1 0 89 0
HISTOGENICS INC COM 43358V109 258 150,630 SH   DFND 1 0 150,630 0
HORIZON PHARMA PLC SHS G4617B955 763 463 SH Put DFND 1 0 463 0
HORIZON PHARMA PLC SHS G4617B905 3,632 2,205 SH Call DFND 1 0 2,205 0
IGNYTA INC COM 451731103 1,220 225,000 SH   DFND 1 0 225,000 0
ILLUMINA INC COM 452327109 2,808 20,000 SH   DFND 1 0 20,000 0
IMMUNOCELLULAR THERAPEUTICS INC COM 452536105 1,025 4,452,128 SH   DFND 1 0 4,452,128 0
IMMUNOMEDICS INC COM 452907108 986 425,000 SH   DFND 1 0 425,000 0
INFINITY PHARMACEUTICALS INC COM 45665G903 22 167 SH Call DFND 1 0 167 0
INFINITY PHARMACEUTICALS INC COM 45665G953 30 225 SH Put DFND 1 0 225 0
INFINITY PHARMACEUTICALS INC COM 45665G303 30 22,500 SH   DFND 1 0 22,500 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 792 106,454 SH   DFND 1 0 106,454 0
INSMED INC COM 457669307 433 43,964 SH   DFND 1 0 43,964 0
INSMED INC COM 457669957 760 771 SH Put DFND 1 0 771 0
INSMED INC COM 457669907 1,327 1,346 SH Call DFND 1 0 1,346 0
INTEC PHARMA LTD SHS M53644106 3,346 743,545 SH   DFND 1 0 743,545 0
INTELLIPHARMACEUTICS INTERNATIONAL INC COM 458173951 19 122 SH Put DFND 1 0 122 0
INTRA CELLULAR THERAPIES INC COM 46116X101 2,793 71,943 SH   DFND 1 0 71,943 0
INTRA CELLULAR THERAPIES INC COM 46116X901 5,330 1,373 SH Call DFND 1 0 1,373 0
INTRA CELLULAR THERAPIES INC COM 46116X951 5,695 1,467 SH Put DFND 1 0 1,467 0
INTREXON CORP COM 46122T952 2,796 1,136 SH Put DFND 1 0 1,136 0
INTREXON CORP COM 46122T102 2,962 120,359 SH   DFND 1 0 120,359 0
INVIVO THERAPEUTICS HOLDINGS CORP COM 46186M909 58 100 SH Call DFND 1 0 100 0
INVIVO THERAPEUTICS HOLDINGS CORP COM 46186M209 3,354 580,343 SH   DFND 1 0 580,343 0
IONIS PHARMACEUTICALS INC COM 462222950 2,292 984 SH Put DFND 1 0 984 0
IONIS PHARMACEUTICALS INC COM 462222900 8,384 3,600 SH Call DFND 1 0 3,600 0
IPATH S&P 500 MT ETN 06740C519 5,485 3,972 SH Call DFND 1 0 3,972 0
IPATH S&P 500 VIX ETN 06742E901 414 300 SH Call DFND 1 0 300 0
ISHARES RUSSELL 2000 ETF ETF 464287951 156,359 13,600 SH Put DFND 1 0 13,600 0
JOHNSON & JOHNSON COM 478160904 34,073 2,809 SH Call DFND 1 0 2,809 0
JUNO THERAPEUTICS INC COM 48205A909 923 240 SH Call DFND 1 0 240 0
KITE PHARMA INC COM 49803L909 4,255 851 SH Call DFND 1 0 851 0
KITOV PHARMACEUTICALS HOLDINGS ADR 49803V107 725 232,524 SH   DFND 1 0 232,524 0
KITOV PHARMACEUTICALS HOLDINGS *W 49803V115 944 1,210,785 SH   DFND 1 0 1,210,785 0
LA JOLLA PHARMACEUTICAL CO COM 503459904 2,333 1,458 SH Call DFND 1 0 1,458 0
LA JOLLA PHARMACEUTICAL CO COM 503459604 3,298 206,131 SH   DFND 1 0 206,131 0
LEXICON PHARMACEUTICALS INC COM 528872952 1,405 979 SH Put DFND 1 0 979 0
LEXICON PHARMACEUTICALS INC COM 528872902 7,634 5,320 SH Call DFND 1 0 5,320 0
LION BIOTECHNOLOGIES INC COM 53619R102 2,975 367,242 SH   DFND 1 0 367,242 0
LION BIOTECHNOLOGIES INC COM 53619R952 6,096 7,526 SH Put DFND 1 0 7,526 0
LIPOCINE INC COM 53630X104 194 63,875 SH   DFND 1 0 63,875 0
MANNKIND CORP COM 56400P951 18,271 52,978 SH Put DFND 1 0 52,978 0
MAST THERAPEUTICS INC COM 576314958 17 369 SH Put DFND 1 0 369 0
MEDGENICS INC COM 58436Q203 770 138,777 SH   DFND 1 0 138,777 0
MEDICINES CO COM 584688105 235 7,000 SH   DFND 1 0 7,000 0
MEDICINES CO COM 584688955 336 100 SH Put DFND 1 0 100 0
MEDICINES CO COM 584688905 12,154 3,614 SH Call DFND 1 0 3,614 0
MEDIVATION INC COM 58501N951 271 45 SH Put DFND 1 0 45 0
MEDIVATION INC COM 58501N101 271 4,500 SH   DFND 1 0 4,500 0
MINERVA NEUROSCIENCES INC COM 603380106 388 38,000 SH   DFND 1 0 38,000 0
MIRATI THERAPEUTICS INC COM 60468T955 586 107,235 SH   DFND 1 0 107,235 0
MOMENTA PHARMACEUTICALS INC COM 60877T950 172 159 SH Put DFND 1 0 159 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 1,572 145,600 SH   DFND 1 0 145,600 0
MOMENTA PHARMACEUTICALS INC COM 60877T900 1,875 1,736 SH Call DFND 1 0 1,736 0
MONSANTO CO COM 61166W901 55,159 5,334 SH Call DFND 1 0 5,334 0
MYLAN N.V. SHS N59465909 12,124 2,804 SH Call DFND 1 0 2,804 0
NATERA INC COM 632307904 174 144 SH Call DFND 1 0 144 0
NEURALSTEM INC COM 64127R302 1,893 6,503,800 SH   DFND 1 0 6,503,800 0
NEUROCRINE BIOSCIENCES INC COM 64125C909 3,695 813 SH Call DFND 1 0 813 0
NEUROMETRIX INC COM 641255500 286 172,236 SH   DFND 1 0 172,236 0
NEUROMETRIX INC *W 641255153 612 3,060,197 SH   DFND 1 0 3,060,197 0
NEWLINK GENETICS CORP COM 651511957 97 162 SH Put DFND 1 0 162 0
NEWLINK GENETICS CORP COM 651511107 318 28,261 SH   DFND 1 0 28,261 0
NEWLINK GENETICS CORP COM 651511907 3,463 5,771 SH Call DFND 1 0 5,771 0
NIVALIS THERAPEUTICS INC COM 65481J109 2,951 641,492 SH   DFND 1 0 641,492 0
NORTHWEST BIOTHERAPEUTICS INC COM 66737P950 47 813 SH Put DFND 1 0 813 0
NORTHWEST BIOTHERAPEUTICS INC COM 66737P600 512 881,585 SH   DFND 1 0 881,585 0
NOVAVAX INC COM 670002104 1,038 142,726 SH   DFND 1 0 142,726 0
NOVAVAX INC COM 670002904 2,182 3,001 SH Call DFND 1 0 3,001 0
NOVAVAX INC COM 670002954 7,595 10,447 SH Put DFND 1 0 10,447 0
OCERA THERAPEUTICS INC COM 67552A108 806 424,035 SH   DFND 1 0 424,035 0
ONCOBIOLOGICS INC *W 68235M121 196 436,923 SH   DFND 1 0 436,923 0
ONCOBIOLOGICS INC *W 68235M113 209 426,184 SH   DFND 1 0 426,184 0
ONCOBIOLOGICS INC COM 68235M105 7,035 2,068,968 SH   DFND 1 0 2,068,968 0
ONCOSEC MEDICAL INC COM 68234L207 997 608,052 SH   DFND 1 0 608,052 0
OPGEN INC COM 68373L109 2,470 1,625,000 SH   DFND 1 0 1,625,000 0
OPHTHOTECH CORP COM 683745903 1,842 361 SH Call DFND 1 0 361 0
OPKO HEALTH INC COM 68375N903 1,393 1,491 SH Call DFND 1 0 1,491 0
OPKO HEALTH INC COM 68375N103 1,780 190,554 SH   DFND 1 0 190,554 0
OPKO HEALTH INC COM 68375N953 2,470 2,645 SH Put DFND 1 0 2,645 0
OVASCIENCE INC COM 69014Q101 704 135,101 SH   DFND 1 0 135,101 0
PARATEK PHARMACEUTICALS INC COM 699374902 341 245 SH Call DFND 1 0 245 0
PARATEK PHARMACEUTICALS INC COM 699374302 4,256 305,964 SH   DFND 1 0 305,964 0
PARNELL PHARMACEUTICALS HOLDINGS LTD SHS Q73622104 635 389,400 SH   DFND 1 0 389,400 0
PFIZER INC COM 717081903 35,210 10,000 SH Call DFND 1 0 10,000 0
PIERIS PHARMACEUTICALS ORD SHS COM 720795103 2,602 1,615,992 SH   DFND 1 0 1,615,992 0
PROGENICS PHARMACEUTICALS INC COM 743187956 55 130 SH Put DFND 1 0 130 0
PROGENICS PHARMACEUTICALS INC COM 743187906 152 361 SH Call DFND 1 0 361 0
PROGENICS PHARMACEUTICALS INC COM 743187106 738 174,900 SH   DFND 1 0 174,900 0
PRONAI THERAPEUTICS INC COM 74346L101 1,174 590,011 SH   DFND 1 0 590,011 0
PROQR THERAPEUTICS N.V. SHS N71542109 532 110,000 SH   DFND 1 0 110,000 0
PROVECTUS BIOPHARMACEUTICALS COM 74373P108 35 93,283 SH   DFND 1 0 93,283 0
PSIVIDA CORP COM 74440J101 730 257,800 SH   DFND 1 0 257,800 0
PTC THERAPEUTICS INC COM 69366J900 1,221 1,740 SH Call DFND 1 0 1,740 0
PUMA BIOTECHNOLOGY INC COM 74587V907 1,364 458 SH Call DFND 1 0 458 0
QUEST RESOURCE HOLDING CORP COM 74836W104 382 1,315,708 SH   DFND 1 0 1,315,708 0
RADIUS HEALTH INC COM 750469957 441 120 SH Put DFND 1 0 120 0
RADIUS HEALTH INC COM 750469907 577 157 SH Call DFND 1 0 157 0
REDHILL BIOPHARMA LTD COM 757468103 1,611 147,500 SH   DFND 1 0 147,500 0
REGENERON PHARMACEUTICALS INC COM 75886F907 1,502 43 SH Call DFND 1 0 43 0
REGENERON PHARMACEUTICALS INC COM 75886F107 24,979 71,525 SH   DFND 1 0 71,525 0
REGENERON PHARMACEUTICALS INC COM 75886F957 40,511 1,160 SH Put DFND 1 0 1,160 0
REGENXBIO INC COM 75901B107 3,295 411,926 SH   DFND 1 0 411,926 0
REGULUS THERAPEUTIC INC COM 75915K101 142 49,231 SH   DFND 1 0 49,231 0
REGULUS THERAPEUTIC INC COM 75915K901 3,341 11,560 SH Call DFND 1 0 11,560 0
RELYPSA INC COM 759531956 163 88 SH Put DFND 1 0 88 0
RELYPSA INC COM 759531906 213 115 SH Call DFND 1 0 115 0
RENNOVA HEALTH INC *W 759757115 32 3,225,806 SH   DFND 1 0 3,225,806 0
RETROPHIN INC COM 761299956 8,595 4,826 SH Put DFND 1 0 4,826 0
RETROPHIN INC COM 761299906 16,822 9,445 SH Call DFND 1 0 9,445 0
REVANCE THERAPEUTICS INC COM 761330909 461 339 SH Call DFND 1 0 339 0
REXAHN PHARMACEUTICALS INC COM 761640101 2,279 9,071,168 SH   DFND 1 0 9,071,168 0
RICEBRAN TECHNOLOGIES INC COM 762831204 1,304 785,476 SH   DFND 1 0 785,476 0
RIGEL PHARMACEUTICALS INC COM 766559903 375 1,684 SH Call DFND 1 0 1,684 0
RIGEL PHARMACEUTICALS INC COM 766559603 972 435,957 SH   DFND 1 0 435,957 0
SAGE THERAPEUTICS INC COM 78667J108 2,077 68,950 SH   DFND 1 0 68,950 0
SAGE THERAPEUTICS INC COM 78667J958 10,533 3,496 SH Put DFND 1 0 3,496 0
SAGE THERAPEUTICS INC COM 78667J908 12,079 4,009 SH Call DFND 1 0 4,009 0
SANGAMO BIOSCIENCES INC COM 800677906 2,548 4,400 SH Call DFND 1 0 4,400 0
SAREPTA THERAPEUTICS INC COM 803607100 14,941 783,497 SH   DFND 1 0 783,497 0
SAREPTA THERAPEUTICS INC COM 803607900 29,034 15,225 SH Call DFND 1 0 15,225 0
SAREPTA THERAPEUTICS INC COM 803607950 55,780 29,250 SH Put DFND 1 0 29,250 0
SCYNEXIS INC COM 811292101 1,243 572,928 SH   DFND 1 0 572,928 0
SERES THERAPEUTICS INC COM 81750R902 142 49 SH Call DFND 1 0 49 0
SERES THERAPEUTICS INC COM 81750R102 598 20,590 SH   DFND 1 0 20,590 0
SHIRE PLC COM 82481R106 5,440 29,550 SH   DFND 1 0 29,550 0
SHIRE PLC COM 82481R906 12,849 698 SH Call DFND 1 0 698 0
SHIRE PLC COM 82481R956 12,849 698 SH Put DFND 1 0 698 0
SKYLINE MEDICAL INC COM 83084T309 298 1,957,037 SH   DFND 1 0 1,957,037 0
SORRENTO THERAPEUTICS INC COM 83587F202 1,421 253,805 SH   DFND 1 0 253,805 0
SPDR GOLD TRUST SHS 78463V907 12,652 1,000 SH Call DFND 1 0 1,000 0
SPDR S&P 500 UNIT 78462F953 176,319 8,415 SH Put DFND 1 0 8,415 0
SPDR S&P 500 BIOTECH TR 78464A950 10,050 1,858 SH Put DFND 1 0 1,858 0
STAFFING 360 SOLUTIONS INC COM 852387208 216 136,583 SH   DFND 1 0 136,583 0
STRATA SKIN SCIENCES INC COM 86272A107 623 1,020,524 SH   DFND 1 0 1,020,524 0
SUPERCONDUCTOR TECHNOLOGIES INC COM 867931404 322 1,701,245 SH   DFND 1 0 1,701,245 0
TEARLAB CORP. COM 878193101 1,205 1,882,347 SH   DFND 1 0 1,882,347 0
TENAX THERAPEUTICS INC COM 88032L100 6,671 2,606,035 SH   DFND 1 0 2,606,035 0
TENAX THERAPEUTICS INC COM 88032L950 43 169 SH Put DFND 1 0 169 0
TENAX THERAPEUTICS INC COM 88032L900 86 335 SH Call DFND 1 0 335 0
TENET HEALTHCARE CORP COM 88033G907 224 81 SH Call DFND 1 0 81 0
TESARO INC COM 881569907 18,138 2,158 SH Call DFND 1 0 2,158 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR 881624959 5,023 1,000 SH Put DFND 1 0 1,000 0
TEVA PHARMACEUTICAL INDUSTRIES LTD ADR 881624909 18,173 3,618 SH Call DFND 1 0 3,618 0
THERAPEUTICSMD INC COM 88338N907 980 1,153 SH Call DFND 1 0 1,153 0
TOKAI PHARMACEUTICALS COM 88907J107 4,128 749,205 SH   DFND 1 0 749,205 0
TONIX PHARMACEUTICALS HOLDINGS CORP COM 890260201 1,166 585,914 SH   DFND 1 0 585,914 0
VANDA PHARMACEUTICALS INC COM 921659908 1,555 1,390 SH Call DFND 1 0 1,390 0
VERTEX PHARMACEUTICALS INC COM 92532F950 2,237 260 SH Put DFND 1 0 260 0
VERTEX PHARMACEUTICALS INC COM 92532F900 5,239 609 SH Call DFND 1 0 609 0
VIKING THERAPEUTICS INC *W 92686J114 51 176,113 SH   DFND 1 0 176,113 0
VISTAGEN THERAPEUTICS INC COM 92840H202 2,431 623,317 SH   DFND 1 0 623,317 0
VTV THERAPEUTICS INC CL A 918385105 811 139,747 SH   DFND 1 0 139,747 0
WAFERGEN BIO SYSTEMS INC COM 93041P308 1,533 1,867,250 SH   DFND 1 0 1,867,250 0
WINDTREE THERAPEUTICS INC COM 97382D105 866 448,509 SH   DFND 1 0 448,509 0
XTL BIOPHARMACEUTICALS LTD ADR 98386D208 1,161 1,001,170 SH   DFND 1 0 1,001,170 0
ZAFGEN INC COM 98885E903 557 930 SH Call DFND 1 0 930 0
ZOGENIX INC COM 98978L904 2,199 12,072 SH Call DFND 1 0 12,072 0
ZOGENIX INC COM 98978L204 2,328 289,200 SH   DFND 1 0 289,200 0
ZOSANO PHARMA INC COM 98979H103 170 128,600 SH   DFND 1 0 128,600 0