0001144204-16-119067.txt : 20160815
0001144204-16-119067.hdr.sgml : 20160815
20160815100624
ACCESSION NUMBER: 0001144204-16-119067
CONFORMED SUBMISSION TYPE: 13F-HR
PUBLIC DOCUMENT COUNT: 2
CONFORMED PERIOD OF REPORT: 20160630
FILED AS OF DATE: 20160815
DATE AS OF CHANGE: 20160815
EFFECTIVENESS DATE: 20160815
FILER:
COMPANY DATA:
COMPANY CONFORMED NAME: SABBY MANAGEMENT, LLC
CENTRAL INDEX KEY: 0001535610
IRS NUMBER: 000000000
STATE OF INCORPORATION: DE
FISCAL YEAR END: 1231
FILING VALUES:
FORM TYPE: 13F-HR
SEC ACT: 1934 Act
SEC FILE NUMBER: 028-15245
FILM NUMBER: 161830549
BUSINESS ADDRESS:
STREET 1: 10 MOUNTAINVIEW ROAD
STREET 2: SUITE 205
CITY: UPPER SADDLE RIVER
STATE: NJ
ZIP: 07458
BUSINESS PHONE: 646-307-4527
MAIL ADDRESS:
STREET 1: 10 MOUNTAINVIEW ROAD
STREET 2: SUITE 205
CITY: UPPER SADDLE RIVER
STATE: NJ
ZIP: 07458
13F-HR
1
primary_doc.xml
13F-HR
LIVE
false
false
false
0001535610
XXXXXXXX
06-30-2016
06-30-2016
false
SABBY MANAGEMENT, LLC
10 Mountainview Road
Suite 205
Upper Saddle River
NJ
07458
13F HOLDINGS REPORT
028-15245
N
Robert Grundstein
Chief Operating Officer
646-307-4527
/s/ Robert Grundstein
Upper Saddle River
NJ
08-15-2016
1
287
1916583
01
0001433766
028-13502
Mintz Hal
INFORMATION TABLE
2
infotable.xml
ABBOTT LABS
COM
002824900
2182
555
SH
Call
DFND
1
0
555
0
ABBOTT LABS
COM
002824100
10405
264700
SH
DFND
1
0
264700
0
ABBOTT LABS
COM
002824950
19655
5000
SH
Put
DFND
1
0
5000
0
ABBVIE INC
COM
00287Y959
14530
2347
SH
Put
DFND
1
0
2347
0
ABBVIE INC
COM
00287Y909
111481
18007
SH
Call
DFND
1
0
18007
0
ABEONA THERAPEUTICS ORD SHS
COM
00289Y107
637
270000
SH
DFND
1
0
270000
0
ACADIA PHARMACEUTICALS INC
COM
004225958
1607
495
SH
Put
DFND
1
0
495
0
ACADIA PHARMACEUTICALS INC
COM
004225908
15172
4674
SH
Call
DFND
1
0
4674
0
ACHILLION PHARMACEUTICALS INC
COM
00448Q951
780
1000
SH
Put
DFND
1
0
1000
0
ACHILLION PHARMACEUTICALS INC
COM
00448Q901
2985
3827
SH
Call
DFND
1
0
3827
0
ACLARIS THERAPEUTICS INC
COM
00461U105
292
15812
SH
DFND
1
0
15812
0
ACORDA THERAPEUTICS INC
COM
00484M956
255
100
SH
Put
DFND
1
0
100
0
ACORDA THERAPEUTICS INC 1.75%
NOTE
00484MAA4
8388
9600000
PRN
DFND
1
0
9600000
0
ACURA PHARMACEUTICALS INC
COM
00509L802
959
518444
SH
DFND
1
0
518444
0
ADAMAS PHARMACEUTICALS INC
COM
00548A106
1478
97600
SH
DFND
1
0
97600
0
ADMA BIOLOGICS INC
COM
000899104
595
100000
SH
DFND
1
0
100000
0
ADURO BIOTECH INC
COM
00739L901
1495
1322
SH
Call
DFND
1
0
1322
0
ADVAXIS INC
COM
007624958
113
140
SH
Put
DFND
1
0
140
0
ADVAXIS INC
COM
007624208
113
14000
SH
DFND
1
0
14000
0
ADVERUM BIOTECHNOLOGIES INC.
COM
00773U108
2465
779926
SH
DFND
1
0
779926
0
AERIE PHARMACEUTICALS INC
COM
00771V908
1186
674
SH
Call
DFND
1
0
674
0
AETERNA ZENTARIS INC
COM
007975402
867
265803
SH
DFND
1
0
265803
0
AKARI THERAPEUTICS PLC
ADR
00972G108
235
17428
SH
DFND
1
0
17428
0
AKEBIA THERAPEUTICS INC
COM
00972D105
75
100
SH
Call
DFND
1
0
100
0
ALCOBRA LTD
SHS
M2239P109
82
18317
SH
DFND
1
0
18317
0
ALCOBRA LTD
SHS
M2239P959
184
409
SH
Put
DFND
1
0
409
0
ALCOBRA LTD
SHS
M2239P909
2006
4467
SH
Call
DFND
1
0
4467
0
ALKERMES PLC
SHS
G01767905
7930
1335
SH
Call
DFND
1
0
1335
0
ALLIQUA BIOMEDICAL INC
COM
019621900
54
483
SH
Call
DFND
1
0
483
0
ALLIQUA BIOMEDICAL INC
COM
019621200
1680
1500000
SH
DFND
1
0
1500000
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q957
3363
606
SH
Put
DFND
1
0
606
0
ALNYLAM PHARMACEUTICALS INC
COM
02043Q907
5477
987
SH
Call
DFND
1
0
987
0
AMARIN CORPORATION PLC
ADR
023111956
241
1118
SH
Put
DFND
1
0
1118
0
AMARIN CORPORATION PLC
ADR
023111906
2033
9411
SH
Call
DFND
1
0
9411
0
AMGEN INC
COM
031162100
23444
154082
SH
DFND
1
0
154082
0
AMGEN INC
COM
031162950
59978
3942
SH
Put
DFND
1
0
3942
0
AMICUS THERAPEUTICS INC
COM
03152W109
687
125912
SH
DFND
1
0
125912
0
AMICUS THERAPEUTICS INC
COM
03152W959
1220
2234
SH
Put
DFND
1
0
2234
0
AMICUS THERAPEUTICS INC
COM
03152W909
4364
7992
SH
Call
DFND
1
0
7992
0
AMPLIPHI BIOSCIENCES CORP
COM
03211P202
951
613782
SH
DFND
1
0
613782
0
ANTARES PHARMA INC
COM
036642106
445
424100
SH
DFND
1
0
424100
0
ANTHERA PHARMACEUTICALS INC
COM
03674U201
309
100000
SH
DFND
1
0
100000
0
ANTHERA PHARMACEUTICALS INC
COM
03674U901
518
1677
SH
Call
DFND
1
0
1677
0
ARALEZ PHARMACEUTICALS INC
COM
03852X900
136
413
SH
Call
DFND
1
0
413
0
ARALEZ PHARMACEUTICALS INC
COM
03852X100
754
228364
SH
DFND
1
0
228364
0
ARBUTUS BIOPHARMA CORP
COM
03879J900
233
669
SH
Call
DFND
1
0
669
0
ARBUTUS BIOPHARMA CORP
COM
03879J100
4093
1176031
SH
DFND
1
0
1176031
0
ASSEMBLY BIOSCIENCES INC
COM
045396108
502
90362
SH
DFND
1
0
90362
0
ASTERIAS BIOTHERAPEUTICS INC
COM
04624N107
741
308909
SH
DFND
1
0
308909
0
ATHERSYS INC SHS
COM
04744L956
49
225
SH
Put
DFND
1
0
225
0
ATHERSYS INC SHS
COM
04744L106
199
91746
SH
DFND
1
0
91746
0
AXOVANT SCIENCES LTD
COM
G0750W104
2440
190000
SH
DFND
1
0
190000
0
BARCLAYS BANK IPATH S&P 500 MT
ETN
06740C519
2805
260000
SH
DFND
1
0
260000
0
BENITEC BIOPHARMA LTD
ADR
082053307
438
345576
SH
DFND
1
0
345576
0
BENITEC BIOPHARMA LTD
*W
082053117
24
98146
SH
DFND
1
0
98146
0
BIO BLAST PHARMA LTD
SHS
M20156101
1328
830253
SH
DFND
1
0
830253
0
BIO PATH HOLDINGS INC
COM
09057N102
5947
2988295
SH
DFND
1
0
2988295
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J906
384
1626
SH
Call
DFND
1
0
1626
0
BIODELIVERY SCIENCES INTERNATIONAL INC
COM
09060J106
1854
785799
SH
DFND
1
0
785799
0
BIOGEN INC
COM
09062X953
2418
100
SH
Put
DFND
1
0
100
0
BIOGEN INC
COM
09062X103
2418
10000
SH
DFND
1
0
10000
0
BIOGEN INC
COM
09062X903
45124
1866
SH
Call
DFND
1
0
1866
0
BIOPHARMX CORP
COM
09072X101
622
957000
SH
DFND
1
0
957000
0
BRAINSTORM CELL THERAPEUTICS INC
COM
10501E201
1149
476719
SH
DFND
1
0
476719
0
CANCER GENETICS INC
COM
13739U104
397
199580
SH
DFND
1
0
199580
0
CAPNIA INC.
COM
14066L105
581
501240
SH
DFND
1
0
501240
0
CAPRICOR THERAPEUTICS INC
COM
14070B101
719
182083
SH
DFND
1
0
182083
0
CAPSTONE TURBINE CORP
COM
14067D409
1845
1336901
SH
DFND
1
0
1336901
0
CASCADIAN THERAPEUTICS INC
COM
14740B101
815
864402
SH
DFND
1
0
864402
0
CEL SCI CORP
COM
150837508
3755
8163816
SH
DFND
1
0
8163816
0
CELATOR PHARMACEUTICALS INC
COM
15089R102
800
26500
SH
DFND
1
0
26500
0
CELGENE CORP
COM
151020954
759
77
SH
Put
DFND
1
0
77
0
CELGENE CORP
COM
151020904
6855
695
SH
Call
DFND
1
0
695
0
CELLECTAR BIOSCIENCES INC
*W
15117F120
219
230013
SH
DFND
1
0
230013
0
CELSION CORP.
COM
15117N404
1930
1519365
SH
DFND
1
0
1519365
0
CEMPRA INC
COM
15130J109
1056
64065
SH
DFND
1
0
64065
0
CEMPRA INC
COM
15130J909
2535
1537
SH
Call
DFND
1
0
1537
0
CEMPRA INC
COM
15130J959
3859
2340
SH
Put
DFND
1
0
2340
0
CHAMPIONS ONCOLOGY INC
COM
15870P307
1175
546728
SH
DFND
1
0
546728
0
CIDARA THERAPEUTICS INC
COM
171757107
209
20277
SH
DFND
1
0
20277
0
CLOVIS ONCOLOGY INC
COM
189464950
141
103
SH
Put
DFND
1
0
103
0
CLOVIS ONCOLOGY INC
COM
189464100
821
59836
SH
DFND
1
0
59836
0
CLOVIS ONCOLOGY INC
COM
189464900
2231
1626
SH
Call
DFND
1
0
1626
0
COLLEGIUM PHARMACEUTICAL INC
COM
19459J104
1202
101410
SH
DFND
1
0
101410
0
COMBIMATRIX CORP.
COM
20009T501
41
14391
SH
DFND
1
0
14391
0
COMBIMATRIX CORP.
*W
20009T147
573
855171
SH
DFND
1
0
855171
0
CORSICANTO LTD 3.5%
NOTE
220480AB3
7877
7756000
PRN
DFND
1
0
7756000
0
CYNAPSUS THERAPEUTICS INC
COM
23257Y859
305
18194
SH
DFND
1
0
18194
0
CYTORI THERAPEUTICS INC
*W
23283K121
793
1004065
SH
DFND
1
0
1004065
0
CYTORI THERAPEUTICS INC
COM
23283K204
4110
1966708
SH
DFND
1
0
1966708
0
DEPOMED INC
COM
249908904
1546
788
SH
Call
DFND
1
0
788
0
DERMIRA INC
COM
24983L104
781
26693
SH
DFND
1
0
26693
0
DERMIRA INC
COM
24983L954
845
289
SH
Put
DFND
1
0
289
0
DERMIRA INC
COM
24983L904
1205
412
SH
Call
DFND
1
0
412
0
DEXCOM INC
COM
252131907
9361
1180
SH
Call
DFND
1
0
1180
0
DEXCOM INC
COM
252131957
33430
4214
SH
Put
DFND
1
0
4214
0
DEXTERA SURGICAL INC.
COM
252366109
868
482000
SH
DFND
1
0
482000
0
DURECT CORP
COM
266605904
94
770
SH
Call
DFND
1
0
770
0
DURECT CORP
COM
266605104
3099
2540278
SH
DFND
1
0
2540278
0
DYNAVAX TECHNOLOGIES CORP
COM
268158201
4236
290505
SH
DFND
1
0
290505
0
DYNAVAX TECHNOLOGIES CORP
COM
268158951
8663
5942
SH
Put
DFND
1
0
5942
0
DYNAVAX TECHNOLOGIES CORP
COM
268158901
15618
10712
SH
Call
DFND
1
0
10712
0
EDAP TMS S A
ADR
268311957
52
157
SH
Put
DFND
1
0
157
0
EDAP TMS S A
ADR
268311107
2804
847225
SH
DFND
1
0
847225
0
EIGER BIOPHARMACEUTICALS INC
COM
28249U105
3473
175249
SH
DFND
1
0
175249
0
ELI LILLY & CO
COM
532457958
38517
4891
SH
Put
DFND
1
0
4891
0
ELI LILLY & CO
COM
532457908
237203
30121
SH
Call
DFND
1
0
30121
0
ENDO INTERNATIONAL PLC
SHS
G30401106
936
60061
SH
DFND
1
0
60061
0
EXELIXIS INC
COM
30161Q904
1393
1783
SH
Call
DFND
1
0
1783
0
EXPRESS SCRIPTS HOLDING CO.
COM
30219E103
1242
16386
SH
DFND
1
0
16386
0
EXPRESS SCRIPTS HOLDING CO.
COM
30219E953
5041
665
SH
Put
DFND
1
0
665
0
EYEGATE PHARMACEUTICALS INC
*W
30233M115
2
53893
SH
DFND
1
0
53893
0
EYEGATE PHARMACEUTICALS INC
COM
30233M107
1002
386940
SH
DFND
1
0
386940
0
FIBROGEN INC
COM
31572Q808
1596
97274
SH
DFND
1
0
97274
0
FLEXION THERAPEUTICS INC
COM
33938J106
1508
100800
SH
DFND
1
0
100800
0
FOAMIX PHARMACEUTICALS LTD
SHS
M46135105
1611
253706
SH
DFND
1
0
253706
0
FORWARD PHARMA A/S
ADR
34986J105
1856
102135
SH
DFND
1
0
102135
0
GALECTIN THERAPEUTICS INC
COM
363225202
974
662467
SH
DFND
1
0
662467
0
GALENA BIOPHARMA INC
COM
363256108
53
113530
SH
DFND
1
0
113530
0
GALENA BIOPHARMA INC
COM
363256958
107
2289
SH
Put
DFND
1
0
2289
0
GENVEC INC
COM
37246C307
931
1625435
SH
DFND
1
0
1625435
0
GLOBAL BLOOD THERAPEUTICS INC
COM
37890U908
698
421
SH
Call
DFND
1
0
421
0
GLOBAL BLOOD THERAPEUTICS INC
COM
37890U108
4214
254029
SH
DFND
1
0
254029
0
GW PHARMACEUTICALS PLC
COM
36197T903
1575
172
SH
Call
DFND
1
0
172
0
HALOZYME THERAPEUTICS INC
COM
40637H909
1813
2101
SH
Call
DFND
1
0
2101
0
HCA HOLDINGS INC
COM
40412C951
770
100
SH
Put
DFND
1
0
100
0
HCA HOLDINGS INC
COM
40412C901
71550
9291
SH
Call
DFND
1
0
9291
0
HEARTWARE INTERNATIONAL INC
COM
422368950
514
89
SH
Put
DFND
1
0
89
0
HISTOGENICS INC
COM
43358V109
258
150630
SH
DFND
1
0
150630
0
HORIZON PHARMA PLC
SHS
G4617B955
763
463
SH
Put
DFND
1
0
463
0
HORIZON PHARMA PLC
SHS
G4617B905
3632
2205
SH
Call
DFND
1
0
2205
0
IGNYTA INC
COM
451731103
1220
225000
SH
DFND
1
0
225000
0
ILLUMINA INC
COM
452327109
2808
20000
SH
DFND
1
0
20000
0
IMMUNOCELLULAR THERAPEUTICS INC
COM
452536105
1025
4452128
SH
DFND
1
0
4452128
0
IMMUNOMEDICS INC
COM
452907108
986
425000
SH
DFND
1
0
425000
0
INFINITY PHARMACEUTICALS INC
COM
45665G903
22
167
SH
Call
DFND
1
0
167
0
INFINITY PHARMACEUTICALS INC
COM
45665G953
30
225
SH
Put
DFND
1
0
225
0
INFINITY PHARMACEUTICALS INC
COM
45665G303
30
22500
SH
DFND
1
0
22500
0
INOTEK PHARMACEUTICALS CORP
COM
45780V102
792
106454
SH
DFND
1
0
106454
0
INSMED INC
COM
457669307
433
43964
SH
DFND
1
0
43964
0
INSMED INC
COM
457669957
760
771
SH
Put
DFND
1
0
771
0
INSMED INC
COM
457669907
1327
1346
SH
Call
DFND
1
0
1346
0
INTEC PHARMA LTD
SHS
M53644106
3346
743545
SH
DFND
1
0
743545
0
INTELLIPHARMACEUTICS INTERNATIONAL INC
COM
458173951
19
122
SH
Put
DFND
1
0
122
0
INTRA CELLULAR THERAPIES INC
COM
46116X101
2793
71943
SH
DFND
1
0
71943
0
INTRA CELLULAR THERAPIES INC
COM
46116X901
5330
1373
SH
Call
DFND
1
0
1373
0
INTRA CELLULAR THERAPIES INC
COM
46116X951
5695
1467
SH
Put
DFND
1
0
1467
0
INTREXON CORP
COM
46122T952
2796
1136
SH
Put
DFND
1
0
1136
0
INTREXON CORP
COM
46122T102
2962
120359
SH
DFND
1
0
120359
0
INVIVO THERAPEUTICS HOLDINGS CORP
COM
46186M909
58
100
SH
Call
DFND
1
0
100
0
INVIVO THERAPEUTICS HOLDINGS CORP
COM
46186M209
3354
580343
SH
DFND
1
0
580343
0
IONIS PHARMACEUTICALS INC
COM
462222950
2292
984
SH
Put
DFND
1
0
984
0
IONIS PHARMACEUTICALS INC
COM
462222900
8384
3600
SH
Call
DFND
1
0
3600
0
IPATH S&P 500 MT
ETN
06740C519
5485
3972
SH
Call
DFND
1
0
3972
0
IPATH S&P 500 VIX
ETN
06742E901
414
300
SH
Call
DFND
1
0
300
0
ISHARES RUSSELL 2000 ETF
ETF
464287951
156359
13600
SH
Put
DFND
1
0
13600
0
JOHNSON & JOHNSON
COM
478160904
34073
2809
SH
Call
DFND
1
0
2809
0
JUNO THERAPEUTICS INC
COM
48205A909
923
240
SH
Call
DFND
1
0
240
0
KITE PHARMA INC
COM
49803L909
4255
851
SH
Call
DFND
1
0
851
0
KITOV PHARMACEUTICALS HOLDINGS
ADR
49803V107
725
232524
SH
DFND
1
0
232524
0
KITOV PHARMACEUTICALS HOLDINGS
*W
49803V115
944
1210785
SH
DFND
1
0
1210785
0
LA JOLLA PHARMACEUTICAL CO
COM
503459904
2333
1458
SH
Call
DFND
1
0
1458
0
LA JOLLA PHARMACEUTICAL CO
COM
503459604
3298
206131
SH
DFND
1
0
206131
0
LEXICON PHARMACEUTICALS INC
COM
528872952
1405
979
SH
Put
DFND
1
0
979
0
LEXICON PHARMACEUTICALS INC
COM
528872902
7634
5320
SH
Call
DFND
1
0
5320
0
LION BIOTECHNOLOGIES INC
COM
53619R102
2975
367242
SH
DFND
1
0
367242
0
LION BIOTECHNOLOGIES INC
COM
53619R952
6096
7526
SH
Put
DFND
1
0
7526
0
LIPOCINE INC
COM
53630X104
194
63875
SH
DFND
1
0
63875
0
MANNKIND CORP
COM
56400P951
18271
52978
SH
Put
DFND
1
0
52978
0
MAST THERAPEUTICS INC
COM
576314958
17
369
SH
Put
DFND
1
0
369
0
MEDGENICS INC
COM
58436Q203
770
138777
SH
DFND
1
0
138777
0
MEDICINES CO
COM
584688105
235
7000
SH
DFND
1
0
7000
0
MEDICINES CO
COM
584688955
336
100
SH
Put
DFND
1
0
100
0
MEDICINES CO
COM
584688905
12154
3614
SH
Call
DFND
1
0
3614
0
MEDIVATION INC
COM
58501N951
271
45
SH
Put
DFND
1
0
45
0
MEDIVATION INC
COM
58501N101
271
4500
SH
DFND
1
0
4500
0
MINERVA NEUROSCIENCES INC
COM
603380106
388
38000
SH
DFND
1
0
38000
0
MIRATI THERAPEUTICS INC
COM
60468T955
586
107235
SH
DFND
1
0
107235
0
MOMENTA PHARMACEUTICALS INC
COM
60877T950
172
159
SH
Put
DFND
1
0
159
0
MOMENTA PHARMACEUTICALS INC
COM
60877T100
1572
145600
SH
DFND
1
0
145600
0
MOMENTA PHARMACEUTICALS INC
COM
60877T900
1875
1736
SH
Call
DFND
1
0
1736
0
MONSANTO CO
COM
61166W901
55159
5334
SH
Call
DFND
1
0
5334
0
MYLAN N.V.
SHS
N59465909
12124
2804
SH
Call
DFND
1
0
2804
0
NATERA INC
COM
632307904
174
144
SH
Call
DFND
1
0
144
0
NEURALSTEM INC
COM
64127R302
1893
6503800
SH
DFND
1
0
6503800
0
NEUROCRINE BIOSCIENCES INC
COM
64125C909
3695
813
SH
Call
DFND
1
0
813
0
NEUROMETRIX INC
COM
641255500
286
172236
SH
DFND
1
0
172236
0
NEUROMETRIX INC
*W
641255153
612
3060197
SH
DFND
1
0
3060197
0
NEWLINK GENETICS CORP
COM
651511957
97
162
SH
Put
DFND
1
0
162
0
NEWLINK GENETICS CORP
COM
651511107
318
28261
SH
DFND
1
0
28261
0
NEWLINK GENETICS CORP
COM
651511907
3463
5771
SH
Call
DFND
1
0
5771
0
NIVALIS THERAPEUTICS INC
COM
65481J109
2951
641492
SH
DFND
1
0
641492
0
NORTHWEST BIOTHERAPEUTICS INC
COM
66737P950
47
813
SH
Put
DFND
1
0
813
0
NORTHWEST BIOTHERAPEUTICS INC
COM
66737P600
512
881585
SH
DFND
1
0
881585
0
NOVAVAX INC
COM
670002104
1038
142726
SH
DFND
1
0
142726
0
NOVAVAX INC
COM
670002904
2182
3001
SH
Call
DFND
1
0
3001
0
NOVAVAX INC
COM
670002954
7595
10447
SH
Put
DFND
1
0
10447
0
OCERA THERAPEUTICS INC
COM
67552A108
806
424035
SH
DFND
1
0
424035
0
ONCOBIOLOGICS INC
*W
68235M121
196
436923
SH
DFND
1
0
436923
0
ONCOBIOLOGICS INC
*W
68235M113
209
426184
SH
DFND
1
0
426184
0
ONCOBIOLOGICS INC
COM
68235M105
7035
2068968
SH
DFND
1
0
2068968
0
ONCOSEC MEDICAL INC
COM
68234L207
997
608052
SH
DFND
1
0
608052
0
OPGEN INC
COM
68373L109
2470
1625000
SH
DFND
1
0
1625000
0
OPHTHOTECH CORP
COM
683745903
1842
361
SH
Call
DFND
1
0
361
0
OPKO HEALTH INC
COM
68375N903
1393
1491
SH
Call
DFND
1
0
1491
0
OPKO HEALTH INC
COM
68375N103
1780
190554
SH
DFND
1
0
190554
0
OPKO HEALTH INC
COM
68375N953
2470
2645
SH
Put
DFND
1
0
2645
0
OVASCIENCE INC
COM
69014Q101
704
135101
SH
DFND
1
0
135101
0
PARATEK PHARMACEUTICALS INC
COM
699374902
341
245
SH
Call
DFND
1
0
245
0
PARATEK PHARMACEUTICALS INC
COM
699374302
4256
305964
SH
DFND
1
0
305964
0
PARNELL PHARMACEUTICALS HOLDINGS LTD
SHS
Q73622104
635
389400
SH
DFND
1
0
389400
0
PFIZER INC
COM
717081903
35210
10000
SH
Call
DFND
1
0
10000
0
PIERIS PHARMACEUTICALS ORD SHS
COM
720795103
2602
1615992
SH
DFND
1
0
1615992
0
PROGENICS PHARMACEUTICALS INC
COM
743187956
55
130
SH
Put
DFND
1
0
130
0
PROGENICS PHARMACEUTICALS INC
COM
743187906
152
361
SH
Call
DFND
1
0
361
0
PROGENICS PHARMACEUTICALS INC
COM
743187106
738
174900
SH
DFND
1
0
174900
0
PRONAI THERAPEUTICS INC
COM
74346L101
1174
590011
SH
DFND
1
0
590011
0
PROQR THERAPEUTICS N.V.
SHS
N71542109
532
110000
SH
DFND
1
0
110000
0
PROVECTUS BIOPHARMACEUTICALS
COM
74373P108
35
93283
SH
DFND
1
0
93283
0
PSIVIDA CORP
COM
74440J101
730
257800
SH
DFND
1
0
257800
0
PTC THERAPEUTICS INC
COM
69366J900
1221
1740
SH
Call
DFND
1
0
1740
0
PUMA BIOTECHNOLOGY INC
COM
74587V907
1364
458
SH
Call
DFND
1
0
458
0
QUEST RESOURCE HOLDING CORP
COM
74836W104
382
1315708
SH
DFND
1
0
1315708
0
RADIUS HEALTH INC
COM
750469957
441
120
SH
Put
DFND
1
0
120
0
RADIUS HEALTH INC
COM
750469907
577
157
SH
Call
DFND
1
0
157
0
REDHILL BIOPHARMA LTD
COM
757468103
1611
147500
SH
DFND
1
0
147500
0
REGENERON PHARMACEUTICALS INC
COM
75886F907
1502
43
SH
Call
DFND
1
0
43
0
REGENERON PHARMACEUTICALS INC
COM
75886F107
24979
71525
SH
DFND
1
0
71525
0
REGENERON PHARMACEUTICALS INC
COM
75886F957
40511
1160
SH
Put
DFND
1
0
1160
0
REGENXBIO INC
COM
75901B107
3295
411926
SH
DFND
1
0
411926
0
REGULUS THERAPEUTIC INC
COM
75915K101
142
49231
SH
DFND
1
0
49231
0
REGULUS THERAPEUTIC INC
COM
75915K901
3341
11560
SH
Call
DFND
1
0
11560
0
RELYPSA INC
COM
759531956
163
88
SH
Put
DFND
1
0
88
0
RELYPSA INC
COM
759531906
213
115
SH
Call
DFND
1
0
115
0
RENNOVA HEALTH INC
*W
759757115
32
3225806
SH
DFND
1
0
3225806
0
RETROPHIN INC
COM
761299956
8595
4826
SH
Put
DFND
1
0
4826
0
RETROPHIN INC
COM
761299906
16822
9445
SH
Call
DFND
1
0
9445
0
REVANCE THERAPEUTICS INC
COM
761330909
461
339
SH
Call
DFND
1
0
339
0
REXAHN PHARMACEUTICALS INC
COM
761640101
2279
9071168
SH
DFND
1
0
9071168
0
RICEBRAN TECHNOLOGIES INC
COM
762831204
1304
785476
SH
DFND
1
0
785476
0
RIGEL PHARMACEUTICALS INC
COM
766559903
375
1684
SH
Call
DFND
1
0
1684
0
RIGEL PHARMACEUTICALS INC
COM
766559603
972
435957
SH
DFND
1
0
435957
0
SAGE THERAPEUTICS INC
COM
78667J108
2077
68950
SH
DFND
1
0
68950
0
SAGE THERAPEUTICS INC
COM
78667J958
10533
3496
SH
Put
DFND
1
0
3496
0
SAGE THERAPEUTICS INC
COM
78667J908
12079
4009
SH
Call
DFND
1
0
4009
0
SANGAMO BIOSCIENCES INC
COM
800677906
2548
4400
SH
Call
DFND
1
0
4400
0
SAREPTA THERAPEUTICS INC
COM
803607100
14941
783497
SH
DFND
1
0
783497
0
SAREPTA THERAPEUTICS INC
COM
803607900
29034
15225
SH
Call
DFND
1
0
15225
0
SAREPTA THERAPEUTICS INC
COM
803607950
55780
29250
SH
Put
DFND
1
0
29250
0
SCYNEXIS INC
COM
811292101
1243
572928
SH
DFND
1
0
572928
0
SERES THERAPEUTICS INC
COM
81750R902
142
49
SH
Call
DFND
1
0
49
0
SERES THERAPEUTICS INC
COM
81750R102
598
20590
SH
DFND
1
0
20590
0
SHIRE PLC
COM
82481R106
5440
29550
SH
DFND
1
0
29550
0
SHIRE PLC
COM
82481R906
12849
698
SH
Call
DFND
1
0
698
0
SHIRE PLC
COM
82481R956
12849
698
SH
Put
DFND
1
0
698
0
SKYLINE MEDICAL INC
COM
83084T309
298
1957037
SH
DFND
1
0
1957037
0
SORRENTO THERAPEUTICS INC
COM
83587F202
1421
253805
SH
DFND
1
0
253805
0
SPDR GOLD TRUST
SHS
78463V907
12652
1000
SH
Call
DFND
1
0
1000
0
SPDR S&P 500
UNIT
78462F953
176319
8415
SH
Put
DFND
1
0
8415
0
SPDR S&P 500 BIOTECH
TR
78464A950
10050
1858
SH
Put
DFND
1
0
1858
0
STAFFING 360 SOLUTIONS INC
COM
852387208
216
136583
SH
DFND
1
0
136583
0
STRATA SKIN SCIENCES INC
COM
86272A107
623
1020524
SH
DFND
1
0
1020524
0
SUPERCONDUCTOR TECHNOLOGIES INC
COM
867931404
322
1701245
SH
DFND
1
0
1701245
0
TEARLAB CORP.
COM
878193101
1205
1882347
SH
DFND
1
0
1882347
0
TENAX THERAPEUTICS INC
COM
88032L100
6671
2606035
SH
DFND
1
0
2606035
0
TENAX THERAPEUTICS INC
COM
88032L950
43
169
SH
Put
DFND
1
0
169
0
TENAX THERAPEUTICS INC
COM
88032L900
86
335
SH
Call
DFND
1
0
335
0
TENET HEALTHCARE CORP
COM
88033G907
224
81
SH
Call
DFND
1
0
81
0
TESARO INC
COM
881569907
18138
2158
SH
Call
DFND
1
0
2158
0
TEVA PHARMACEUTICAL INDUSTRIES LTD
ADR
881624959
5023
1000
SH
Put
DFND
1
0
1000
0
TEVA PHARMACEUTICAL INDUSTRIES LTD
ADR
881624909
18173
3618
SH
Call
DFND
1
0
3618
0
THERAPEUTICSMD INC
COM
88338N907
980
1153
SH
Call
DFND
1
0
1153
0
TOKAI PHARMACEUTICALS
COM
88907J107
4128
749205
SH
DFND
1
0
749205
0
TONIX PHARMACEUTICALS HOLDINGS CORP
COM
890260201
1166
585914
SH
DFND
1
0
585914
0
VANDA PHARMACEUTICALS INC
COM
921659908
1555
1390
SH
Call
DFND
1
0
1390
0
VERTEX PHARMACEUTICALS INC
COM
92532F950
2237
260
SH
Put
DFND
1
0
260
0
VERTEX PHARMACEUTICALS INC
COM
92532F900
5239
609
SH
Call
DFND
1
0
609
0
VIKING THERAPEUTICS INC
*W
92686J114
51
176113
SH
DFND
1
0
176113
0
VISTAGEN THERAPEUTICS INC
COM
92840H202
2431
623317
SH
DFND
1
0
623317
0
VTV THERAPEUTICS INC
CL A
918385105
811
139747
SH
DFND
1
0
139747
0
WAFERGEN BIO SYSTEMS INC
COM
93041P308
1533
1867250
SH
DFND
1
0
1867250
0
WINDTREE THERAPEUTICS INC
COM
97382D105
866
448509
SH
DFND
1
0
448509
0
XTL BIOPHARMACEUTICALS LTD
ADR
98386D208
1161
1001170
SH
DFND
1
0
1001170
0
ZAFGEN INC
COM
98885E903
557
930
SH
Call
DFND
1
0
930
0
ZOGENIX INC
COM
98978L904
2199
12072
SH
Call
DFND
1
0
12072
0
ZOGENIX INC
COM
98978L204
2328
289200
SH
DFND
1
0
289200
0
ZOSANO PHARMA INC
COM
98979H103
170
128600
SH
DFND
1
0
128600
0