The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACTINIUM PHARMACEUTICALS COM 00507W107 342 972,285 SH   DFND 1 0 972,285 0
AIKIDO PHARMA INC COM 008875106 281 342,121 SH   DFND 1 0 342,121 0
ALLENA PHARMACEUTICALS COM 018119107 2,420 1,531,446 SH   DFND 1 0 1,531,446 0
ALTIMMUNE INC COM 02155H900 202 189 SH Call DFND 1 0 189 0
ALTIMMUNE INC COM 02155H950 3,062 2,859 SH Put DFND 1 0 2,859 0
ARCADIA BIOSCIENCES INC COM 039014204 224 59,543 SH   DFND 1 0 59,543 0
ASTRAZENECA PLC ADR 046353108 1,657 31,320 SH   DFND 1 0 31,320 0
ASTRAZENECA PLC ADR 046353958 3,570 675 SH Put DFND 1 0 675 0
AURINIA PHARMACEUTICALS COM 05156V102 406 25,000 SH   DFND 1 0 25,000 0
AURINIA PHARMACEUTICALS COM 05156V902 453 279 SH Call DFND 1 0 279 0
AVEO PHARMACEUTICALS INC COM 053588307 450 87,319 SH   DFND 1 0 87,319 0
AVEO PHARMACEUTICALS INC COM 053588907 2,191 4,255 SH Call DFND 1 0 4,255 0
AVEO PHARMACEUTICALS INC COM 053588957 3,763 7,307 SH Put DFND 1 0 7,307 0
AVINGER INC COM 053734604 676 2,183,464 SH   DFND 1 0 2,183,464 0
BAUDAX BIO INC COM 07160F957 190 459 SH Put DFND 1 0 459 0
BENITEC BIOPHARMA INC COM 08205P100 94 11,863 SH   DFND 1 0 11,863 0
BIO PATH HLDGS INC COM 09057N300 227 45,000 SH   DFND 1 0 45,000 0
BIOGEN INC COM 09062X103 27,799 103,902 SH   DFND 1 0 103,902 0
BIOGEN INC COM 09062X903 48,266 1,804 SH Call DFND 1 0 1,804 0
BIOGEN INC COM 09062X953 68,065 2,544 SH Put DFND 1 0 2,544 0
BRAINSTORM CELL THERAPEUTICS COM 10501E951 33,173 9,329 SH Put DFND 1 0 9,329 0
CATABASIS PHARMS COM 14875P906 65 101 SH Call DFND 1 0 101 0
CATABASIS PHARMS COM 14875P956 306 476 SH Put DFND 1 0 476 0
CELLDEX THERAPEUTICS INC COM 15117B202 950 73,094 SH   DFND 1 0 73,094 0
CELLDEX THERAPEUTICS INC COM 15117B902 1,017 782 SH Call DFND 1 0 782 0
CEL-SCI CORP COM 150837607 1,319 88,417 SH   DFND 1 0 88,417 0
CEL-SCI CORP COM 150837907 2,923 1,959 SH Call DFND 1 0 1,959 0
CEL-SCI CORP COM 150837957 4,601 3,084 SH Put DFND 1 0 3,084 0
CELSION CORP COM 15117N903 243 653 SH Call DFND 1 0 653 0
CELSION CORP COM 15117N953 54 145 SH Put DFND 1 0 145 0
CHINA JO JO DRUGSTORES COM 16949A206 69 50,000 SH   DFND 1 0 50,000 0
CURIS INC COM 231269200 2,743 2,267,068 SH   DFND 1 0 2,267,068 0
CYTOKINETICS INC COM 23282W905 370 157 SH Call DFND 1 0 157 0
ENERGY FOCUS INC COM 29268T959 83 120 SH Put DFND 1 0 120 0
ENLIVEX THERAPEUTICS LTD COM M4130Y106 65 12,925 SH   DFND 1 0 12,925 0
FIBROGEN INC COM 31572Q808 1,360 33,560 SH   DFND 1 0 33,560 0
FIBROGEN INC COM 31572Q958 5,703 1,407 SH Put DFND 1 0 1,407 0
GENOCEA BIOSCIENCES INC COM 372427401 288 125,312 SH   DFND 1 0 125,312 0
GENOCEA BIOSCIENCES INC COM 372427901 489 2,126 SH Call DFND 1 0 2,126 0
GENPREX INC COM 372446104 372 118,584 SH   DFND 1 0 118,584 0
GLOBUS MARITIME LTD COM Y27265407 1,275 4,776,735 SH   DFND 1 0 4,776,735 0
HOTH THERAPEUTICS INC COM 44148G105 177 68,681 SH   DFND 1 0 68,681 0
IMMUNIC INC COM 4525EP101 642 53,009 SH   DFND 1 0 53,009 0
INOVIO PHARMACEUTICALS COM 45773H201 54 2,000 SH   DFND 1 0 2,000 0
INOVIO PHARMACEUTICALS COM 45773H901 6,721 2,494 SH Call DFND 1 0 2,494 0
INOVIO PHARMACEUTICALS COM 45773H951 5,821 2,160 SH Put DFND 1 0 2,160 0
INSPIREMD INC COM 45779A853 22 48,300 SH   DFND 1 0 48,300 0
IONIS PHARMACEUTICALS COM 462222900 731 124 SH Call DFND 1 0 124 0
IONIS PHARMACEUTICALS COM 462222950 991 168 SH Put DFND 1 0 168 0
ISHARES NASDAQ BIOTECH ETF 464287556 1,248 9,130 SH   DFND 1 0 9,130 0
ISHARES NASDAQ BIOTECH ETF 464287906 2,583 189 SH Call DFND 1 0 189 0
ISHARES NASDAQ BIOTECH ETF 464287956 14,393 1,053 SH Put DFND 1 0 1,053 0
ISHARES RUSSELL 2000 ETF 464287905 15,034 1,050 SH Call DFND 1 0 1,050 0
ISHARES RUSSELL 2000 ETF 464287955 27,219 1,901 SH Put DFND 1 0 1,901 0
LIPOCINE INC NEW COM 53630X104 18 14,452 SH   DFND 1 0 14,452 0
LIPOCINE INC NEW COM 53630X954 13 100 SH Put DFND 1 0 100 0
LM FUNDING AMERICA INC COM 502074305 34 25,000 SH   DFND 1 0 25,000 0
MEDIGUS LTD *W 58471G128 123 585,859 SH   DFND 1 0 585,859 0
MODERNA INC COM 60770K107 4,616 71,893 SH   DFND 1 0 71,893 0
MODERNA INC COM 60770K907 1,015 158 SH Call DFND 1 0 158 0
MODERNA INC COM 60770K957 18,717 2,915 SH Put DFND 1 0 2,915 0
MUSTANG BIO INC COM 62818Q104 747 234,778 SH   DFND 1 0 234,778 0
NEOVASC INC COM 64065J304 776 326,023 SH   DFND 1 0 326,023 0
NEUROBO PHARMACEUTICALS COM 64132R107 1,872 232,547 SH   DFND 1 0 232,547 0
NIKOLA CORP COM 654110955 2,330 345 SH Put DFND 1 0 345 0
NIKOLA CORP *W 654110113 1,145 34,500 SH   DFND 1 0 34,500 0
ODONATE THERAPEUTICS INC COM 676079106 1,715 40,500 SH   DFND 1 0 40,500 0
ODONATE THERAPEUTICS INC COM 676079906 944 223 SH Call DFND 1 0 223 0
ODONATE THERAPEUTICS INC COM 676079956 2,011 475 SH Put DFND 1 0 475 0
ORAMED PHARMS INC COM 68403P953 335 949 SH Put DFND 1 0 949 0
PARETEUM CORP COM 69946T207 35 56,757 SH   DFND 1 0 56,757 0
PARETEUM CORP COM 69946T957 12 190 SH Put DFND 1 0 190 0
PAVMED INC *W 70387R122 867 842,210 SH   DFND 1 0 842,210 0
PHASEBIO PHARMACEUTICALS COM 717224109 354 76,970 SH   DFND 1 0 76,970 0
PIEDMONT LITHIUM LTD COM 720162106 2,875 498,259 SH   DFND 1 0 498,259 0
PLURISTEM THERAPEUTICS COM 72940R300 263 29,699 SH   DFND 1 0 29,699 0
PLURISTEM THERAPEUTICS COM 72940R950 5,425 6,137 SH Put DFND 1 0 6,137 0
POLARITYTE INC COM 731094958 25 200 SH Put DFND 1 0 200 0
PREDICTIVE ONCOLOGY INC COM 74039M200 367 223,540 SH   DFND 1 0 223,540 0
PULMATRIX INC COM 74584P202 21 11,944 SH   DFND 1 0 11,944 0
REMARK HOLDINGS INC COM 75955K102 80 33,953 SH   DFND 1 0 33,953 0
REMARK HOLDINGS INC COM 75955K952 97 413 SH Put DFND 1 0 413 0
REWALK ROBOTICS LTD COM M8216Q200 34 19,082 SH   DFND 1 0 19,082 0
SCPHARMACEUTICALS INC COM 810648105 926 125,752 SH   DFND 1 0 125,752 0
SECTOR HEALTHCARE ETF 81369Y209 10,535 105,280 SH   DFND 1 0 105,280 0
SECTOR HEALTHCARE ETF 81369Y909 6,665 666 SH Call DFND 1 0 666 0
SECTOR HEALTHCARE ETF 81369Y959 46,372 4,634 SH Put DFND 1 0 4,634 0
SENECA BIOPHARMA INC COM 81689B103 83 115,001 SH   DFND 1 0 115,001 0
SOLITON INC COM 834251100 800 102,891 SH   DFND 1 0 102,891 0
SORRENTO THERAPEUTICS INC COM 83587F902 3,237 5,155 SH Call DFND 1 0 5,155 0
SORRENTO THERAPEUTICS INC COM 83587F952 6,331 10,081 SH Put DFND 1 0 10,081 0
SPDR GOLD TRUST ETF 78463V907 7,297 436 SH Call DFND 1 0 436 0
SPDR GOLD TRUST ETF 78463V957 3,598 215 SH Put DFND 1 0 215 0
SPDR S&P 500 ETF 78462F903 17,299 561 SH Call DFND 1 0 561 0
SPDR S&P 500 ETF 78462F953 18,810 610 SH Put DFND 1 0 610 0
SPDR SERIES TRUST ETF 78464A870 241 2,150 SH   DFND 1 0 2,150 0
SPDR SERIES TRUST ETF 78464A950 25,894 2,313 SH Put DFND 1 0 2,313 0
TRANSENTERIX INC COM 89366M950 43 794 SH Put DFND 1 0 794 0
TRILLIUM THERAPEUTICS COM 89620X906 1,840 2,275 SH Call DFND 1 0 2,275 0
TRILLIUM THERAPEUTICS COM 89620X956 426 527 SH Put DFND 1 0 527 0
XERIS PHARMACEUTICALS COM 98422L107 2,889 1,086,031 SH   DFND 1 0 1,086,031 0
XPRESSPA GROUP INC COM 98420U953 141 337 SH Put DFND 1 0 337 0
YATRA ONLINE INC COM G98338109 441 650,000 SH   DFND 1 0 650,000 0