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                           August 18, 2021

       Jeffrey F. Eisenberg
       Chief Executive Officer
       Xenetic Biosciences, Inc.
       40 Speen Street, Suite 102
       Framingham, MA 01701

                                                        Re: Xenetic
Biosciences, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed August 13,
2021
                                                            File No. 333-258810

       Dear Mr. Eisenberg:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jeffrey
Gabor at 202-551-2544 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Life Sciences
       cc:                                              Danielle Price, Esq.