8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): September 2, 2021

Chemomab Therapeutics Ltd.

(Exact name of Registrant as Specified in Its Charter)

State of Israel	001-38807	81-3676773
(State or Other Jurisdiction	(Commission	(IRS Employer
of Incorporation)	File Number)	Identification No.)

Kiryat Atidim, Building 7
Tel Aviv, Israel	6158002
(Address of principal executive offices)	(Zip Code)

Registrant’s telephone number, including area code: +972-77-331-0156

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐	Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
☐	Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
☐	Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
☐	Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class	Trading Symbol(s)	Name of each exchange on which registered
American Depositary Shares, each representing twenty (20) ordinary shares, no par value per share	CMMB	Nasdaq Capital Market
Ordinary shares, no par value per share	N/A	Nasdaq Capital Market*

* Not for trading; only in connection with the registration of American Depositary Shares.

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).

Emerging growth company  ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

Item 5.02 Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

(c)  Appointment of Chief Executive Officer

On September 2, 2021, Chemomab Therapeutics Ltd. (the “Company”) announced the appointment of Dr. Dale Pfost as Chief Executive Officer of the Company. The effectiveness of Dr. Pfost’s appointment is subject to the approval of Dr. Pfost’s compensation terms by the shareholders of the Company. Dr. Pfost will replace Dr. Adi Mor, who will step down from her role as Chief Executive Officer, effective as of the appointment of Dr. Pfost, and who will continue to be employed by the Company as Chief Scientific Officer where she will oversee scientific strategy and R&D operations. Dr. Mor will also continue to serve as a Board member.

In connection with Dr. Pfost’s appointment as Chief Executive Officer, the Company and Dr. Pfost entered into an executive employment agreement that will be subject to shareholder approval, in accordance with the requirements of the Israeli Companies Law, 5759-1999.

In addition to Dr. Pfost’s prospective service as the Chief Executive Officer of the Company, he is also expected to be appointed to the Company’s board of directors.

The biographical information for Dr. Pfost appears below:

Dr. Dale Pfost has 35 years of experience as an entrepreneur, investor and business executive. Since 2019, Dr. Pfost has served as Chief Executive Officer and Chairman of the Board of Lodo Therapeutics Corporation. From 2009 until 2019, Dr. Pfost served in a variety of roles at Microbiome Therapeutics, LLC, a company which he co-founded, including as a board member and Chief Executive Officer from 2009 until 2010 and again from 2016 until 2019. From 2010 until 2019, he served as a General Partner at Advent Life Sciences. From 2013 until 2017, Dr. Pfost served in a variety of roles at Vestagen Protective Technologies, including Chairman, Executive Chairman from 2013 until 2017, and Chief Executive Officer from 2015 until 2016. Prior to that, Dr. Pfost held various executive positions at the following companies: Chief Executive Officer at Receptor Biologix Inc. (from 2008 until 2009), President, Chief Executive Officer and Chairman at Acuity Pharmaceuticals, Inc. (from 2003 until 2007), President, Chief Executive Officer and Chairman at Orchid Biosciences, Inc. (from 1996 until 2002), President, Chief Executive Officer and Managing Director at Oxford Glycosciences Ltd. (from 1988 until 1996) and Director of Robotics and Automated Chemistry Systems at Smithkline Beckman from 1984 until 1988. In addition to the foregoing, Dr. Pfost has served on the board of directors of several companies, including Bioelectronica Corp., AxoSim, Inc., JMB Companies LLC, Aura Bioscience, Louisiana BIO and CN Creative. Dr. Pfost earned his BS from the University of California, Santa Barbara, and a PhD in physics from Brown University.

Other than that which is disclosed herein, there are no arrangements or understandings between Dr. Pfost and any other persons pursuant to which he was appointed to serve as Chief Executive Officer or as a Class III director and there are no family relationships between Dr. Pfost and any director or executive officer of the Company. Dr. Pfost has no direct or indirect material interest in any transaction required to be disclosed pursuant to Item 404(a) of Regulation S-K.

Item 7.01 Regulation FD Disclosure.

As described in Item 5.02 above, on September 2, 2021, the Company issued a press release announcing the appointment of Dr. Dale Pfost as the Chief Executive Officer of the Company, which appointment is subject to the approval of the shareholders of the Company. A copy of the press release is furnished herewith as Exhibit 99.1 and incorporated herein by reference.

Additionally, attached as Exhibit 99.2 to this Current Report on Form 8-K, and incorporated into this Item 7.01 by reference, is an updated corporate presentation of the Company.

Item 9.01 Financial Statements and Exhibits.

(d) Exhibits

Exhibit Number	Exhibit Description
99.1	Press release issued by Chemomab Therapeutics Ltd. dated September 2, 2021
99.2	Corporate Presentation of Chemomab Therapeutics Ltd. (furnished herewith)
104	Cover Page Interactive Data File - the cover page XBRL tags are embedded within the Inline XBRL document.

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SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

	CHEMOMAB THERAPEUTICS LTD.
Date: September 2, 2021	By:	/s/ Sigal Fattal
		Name: Sigal Fattal
		Title: Chief Financial Officer

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EX-99.1

Exhibit 99.1

Chemomab Therapeutics Announces Appointment of Dale Pfost as Chief

Executive Officer

Dr. Adi Mor continues as Chief Scientific Officer, directing scientific strategy and overseeing

R&D operations

TEL AVIV, Israel, September 2, 2021 -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), a clinical-stage biotech company focused on the discovery and development of innovative therapeutics for inflammatory and fibrotic diseases with high unmet need, today announced it has appointed Dale R. Pfost, PhD, as Chief Executive Officer (CEO). Dr. Adi Mor, Company co-founder and current CEO, will continue in her role as Chief Scientific Officer (CSO) and remain as a member of the Board of Directors. The addition of Dr. Pfost, who brings more than 30 years of diverse experience as a life science senior executive, entrepreneur and venture investor, reflects a planned strategic expansion of the Chemomab senior management team. Dr. Pfost is expected to join the Company’s Board of Directors and subsequently become the company’s Chairman in 2022.

“The Board and I welcome Dale and thank Adi for her tremendous contributions as founding chief executive of Chemomab,” said Stephen Squinto, PhD, Chairman of the Board at Chemomab and an Executive Partner at OrbiMed. “Adi built both the scientific and business platforms for Chemomab and she will continue to be instrumental in the development of our first-in-class therapeutic addressing a novel target for multiple inflammatory and fibrotic diseases, helping position the company for future success. We look forward to her continued contributions as we evolve and grow.”

Dr. Pfost has served as CEO of six biotechnology companies, three of which became publicly traded with valuations exceeding two billion dollars. He has successfully completed dozens of financings, overseen numerous M&A transactions and served as a director at multiple public and private life science firms.

Dr. Squinto continued, “We are delighted that Dale is coming on board as CEO. He is a seasoned biotechnology industry veteran with deep relationships and a history of successfully building innovative companies through organic growth and strategic acquisitions. With two Phase 2 studies underway and a third poised to kick off in the coming months, Chemomab is making excellent progress on realizing its potential as a premier company addressing diseases with large unmet medical needs. We look forward to Dale’s astute leadership during the next stage of growth.”

Dr. Pfost said, “Adi and the Chemomab team have built an impressive company based on a unique asset with multiple high value applications. They have demonstrated exceptional skill in undertaking translational work and establishing clinical programs, and we look forward to extending the company’s already strong network of scientific and clinical collaborators in the U.S. This is an exciting time to join, as the company is well-positioned for both continued progress with its current programs and for leveraging strategic growth opportunities.”

Dr. Mor said, “We advanced our novel anti-CCL24 antibody from the lab to the clinic and executed a successful merger earlier in the year. Now is the right time to add to our leadership team as we expand our strategic scope and our geographic presence in the U.S. Dale has a terrific track record of successfully growing biotech companies and I welcome the opportunity to work with him to build on the strong foundation we have achieved to date.”

Until it was acquired in May of this year, Dr. Pfost was Chairman and CEO of innovative drug discovery firm Lodo Therapeutics. Previously, he was the U.S.-based General Partner at London-based venture capital firm Advent Life Sciences and served as Executive Chairman of portfolio companies CN Creative and Vestagen Protective Technologies. He co-founded and was acting CEO of MicroBiome Therapeutics in the year leading up to its acquisition. Dr. Pfost also was founding CEO of Acuity Pharmaceuticals, which merged to form OPKO Health. He was the founding CEO of Oxford GlycoSciences and genomics pioneer Orchid BioSciences. Dr. Pfost was also CEO at anti-cancer company Receptor BioLogix, where he led its successful acquisition. His first company, which he started in graduate school, was acquired by SmithKline Beckman and produced the Biomek, still a leading laboratory automation system today. Dr. Pfost is the co-author of 10 scientific papers and an inventor on 10 patents. He earned a BS degree from the University of California Santa Barbara and a PhD in physics from Brown University.

Dr. Pfost’s appointment as CEO and member of the Board will become effective upon the approval of Chemomab shareholders, as is required for public companies based in Israel.  A shareholder vote is expected in the fourth quarter of 2021.His expected appointment as Chairman in 2022 will also require shareholder approval.

About Chemomab Therapeutics Ltd.

Chemomab is a clinical-stage biotech company focusing on the discovery and development of innovative therapeutics for inflammatory and fibrosis-related diseases with high unmet need. Based on the unique and pivotal role of the soluble protein CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody designed to bind and block CCL24 activity. CM-101 has potential to treat multiple severe and life-threatening inflammatory and fibrotic diseases. It is currently in Phase II safety and efficacy trials in patients with primary sclerosing cholangitis (PSC) and liver fibrosis, with a third Phase II trial in systemic sclerosis (SSc) expected to begin in the first quarter of 2022.

For more information on Chemomab, please visit www.chemomab.com.

Forward Looking Statements

This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act. These forward-looking statements include, among other things, statements regarding the clinical development pathway for CM-101; the future operations of Chemomab and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones; the nature, strategy and focus of Chemomab; the development and commercial potential and potential benefits of any product candidates of Chemomab; and that the product candidates have the potential to address high unmet needs of patients with serious fibrosis-related diseases and conditions. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon Chemomab’s current expectations. Forward-looking statements involve risks and uncertainties. Because such statements deal with future events and are based on Chemomab’s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Chemomab could differ materially from those described in or implied by the statements in this presentation, including: the uncertain and time-consuming regulatory approval process; risks related to Chemomab’s ability to correctly manage its operating expenses and its expenses; Chemomab’s plans to develop and commercialize its product candidates, focusing on CM-101; the timing of initiation of Chemomab’s planned clinical trials; the timing of the availability of data from Chemomab’s clinical trials; the timing of any planned investigational new drug application or new drug application; Chemomab’s plans to research, develop and commercialize its current and future product candidates; the clinical utility, potential benefits and market acceptance of Chemomab’s product candidates; Chemomab’s commercialization, marketing and manufacturing capabilities and strategy; Chemomab’s ability to protect its intellectual property position; and the requirement for additional capital to continue to advance these product candidates, which may not be available on favorable terms or at all. Additional risks and uncertainties relating to Chemomab’s and its business can be found under the caption “Risk Factors” and elsewhere in Chemomab’s filings and reports with the SEC. Chemomab expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Chemomab’s expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based.

Contacts:

Investor Relations:Irina KofflerLifeSci Advisors, LLCPhone: +1-917-734-7387ir@chemomab.com

Media:

Barbara Lindheim

BLL Partners, LLC for Chemomab

Phone: +1-917-355-9234

blindheim@bllbiopartners.com

Chemomab Therapeutics:Sharon ElkobiVP, Business DevelopmentPhone: +972-773-310-156bd@chemomab.com

EX-99.2

Exhibit 99.2

 Pioneering Innovative Treatments for Fibrotic DiseasesCorporate Overview | Non-Confidential | September 2021 

 Forward Looking Statements  This presentation contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act. These forward-looking statements include, among other things, statements regarding the clinical development pathway for CM-101; the future operations of Chemomab and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones; the nature, strategy and focus of Chemomab; the development and commercial potential and potential benefits of any product candidates of Chemomab; and that the product candidates have the potential to address high unmet needs of patients with serious fibrosis-related diseases and conditions. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon Chemomab’s current expectations. Forward-looking statements involve risks and uncertainties.Because such statements deal with future events and are based on Chemomab’s current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Chemomab could differ materially from those described in or implied by the statements in this presentation, including: the uncertain and time-consuming regulatory approval process; risks related to Chemomab’s ability to correctly manage its operating expenses and its expenses; Chemomab’s plans to develop and commercialize its product candidates, including CM-101; the timing of initiation of Chemomab’s planned clinical trials; the timing of the availability of data from Chemomab’s clinical trials; the timing of any planned investigational new drug application or new drug application; Chemomab’s plans to research, develop and commercialize its current and future product candidates; the clinical utility, potential benefits and market acceptance of Chemomab’s product candidates; Chemomab’s commercialization, marketing and manufacturing capabilities and strategy; Chemomab’s ability to protect its intellectual property position; and the requirement for additional capital to continue to advance these product candidates, which may not be available on favorable terms or at all. Additional risks and uncertainties relating to Chemomab’s and its business can be found under the caption “Risk Factors” and elsewhere in Chemomab’s filings and reports with the SEC. Chemomab expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Chemomab’s expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based. This presentation (“Presentation”) is for informational purposes only and does not constitute an offer to sell, solicitation of an offer to buy, or a recommendation to purchase any equity, debt or other financial instruments of Chemomab. The data contained herein is derived from various internal and external sources. No representation is made as to the reasonableness of the assumptions made within or the accuracy or completeness of any other information contained herein. All levels, prices and spreads are historical and do not represent current market levels, prices or spreads, some or all of which may have changed since the issuance of this document. Any data on past performance, modeling contained herein is not an indication as to future performance. Chemomab assume no obligation to update the information in this Presentation. Chemomab does not accept any liability whatsoever for any losses arising from the use of this Presentation or reliance on the information contained herein. Nothing herein shall be deemed to constitute investment, legal, tax, financial, accounting or other advice. This Presentation is being provided for use only by the intended recipient. 

   Discovery and development of innovative therapeutics for rare inflammatory and fibrotic diseases with high unmet need  CM-101, a first-in-class CCL24 neutralizing monoclonal antibody targeting:Primary Sclerosing Cholangitis (PSC)Systemic Sclerosis (SSc)Liver fibrosis  Conducting 2 Phase II clinical trials with 3rd Phase II trial expected to initiate in 1Q22First clinical readouts targeted for 2022 expected to drive multiple value inflections   Global patent exclusivity through 2041. Granted composition of matter patent with multiple additional patents pending.     Investment Highlights  Clinical Stage Biotech Company Focused on Inflammatory-Fibrotic Diseases  Cormorant Asset Management  Cash and equivalents of $67M as of June 30, 2021 enabling runway through mid-2023  Focus  CM-101:A Pipeline in a Product  Near-Term Catalysts  Robust IP Portfolio  Top Tier Investors  Solid Balance Sheet 

                         Experienced Management    ADI MOR, PhDFounding Chief Executive Officer & Chief Scientific Officer  ARNON AHARON, MDChief Medical Officer  SIGAL FATTAL, CPA, MBAChief Financial Officer  DALE PFOST, PhD* Incoming Chief Executive Officer  SHARON ELKOBI, MSc, MBAVP Business Development  MICHAL SEGAL-SALTO, PhDVP Research and Development  *Post shareholder vote 

 Stephen Squinto, PhD Chairman of the Board  Adi Mor, PhDFounding Chief Executive Officer & Chief Scientific Officer  Dale Pfost, PhD* Incoming Chief Executive Officer  Neil Cohen, MADirector  Nissim Darvish, MD, PhDDirector  Joel Maryles, CFA, MBADirector  Alan Moses, MD Director  Claude Nicaise, MDDirector  Board of Directors  Scientific Advisory Board  Prof. Marco Matucci-Cerinic, MD, PhDDirector of the Division of Rheumatology, University of Florence, Italy  Scott L. Friedman, MDThe Dean for Therapeutic Discovery and Chief, Division of Liver Diseases, Mount Sinai, NY, USA  Prof. Dinesh Khanna MD, MBBS, MScDirector of the Scleroderma Program, University of Michigan, Ann Arbor, Michigan, USA  Massimo Pinzani, MD, PhD, FRCP Sheila Sherlock Chair of Hepatology, Director UCLInstitute for Liver and Digestive Health, RFH, London, UK  Gideon Hirschfield, MA MB PhDLily and Terry Horner Chair in Autoimmune Liver Disease, University of Toronto, Toronto General Hospital, Canada  Prof. Francesco Del Galdo, MD, PhDHead of the Scleroderma Program at NIHR, University of Leeds, UK  Experienced Leadership                        *Post shareholder vote 

 Program  Indication  Target  Discovery  Preclinical  Phase 1  Phase 2  Status  CM-101  Primary Sclerosing Cholangitis   CCL24          Enrolling PatientsTop Line Data 2H 2022  CM-101  Systemic Sclerosis  CCL24          Initiation Expected In 1Q 2022  CM-101  Liver Fibrosis  CCL24          Enrolling PatientsTop Line Data 1H 2022  Next-gen  Fibrosis  Screening          In Progress  CM-101: Pipeline in a Product  Addressing Fibrotic Diseases with High Unmet Need     Orphan designation granted from FDA and EMA  Orphan designation granted from FDA and EMA     

 CCL24 is a Novel Therapeutic Target for Fibrosis  Critical Mediator Promoting Inflammation and Fibrosis  CCL24      CCR3    CCL24-regulated cellsFibroblasts (liver, lung and skin), Immune and Epithelial cells  Immune cells recruitment  Fibroblasts activation  Tissue scarring, inflammatory-mediated damage, collagen deposition  Positive Feedback Loop  Organ failure  Damaged tissue CCL24 Secretion   CCL24-secreting cellsImmune (M2 Macrophages, monocytes) and Epithelial cells  Dual role in promoting fibrosisdirectly activates fibroblastsenhances local immune cell recruitmentUnique and differentiated activityex vivo and in vivo data confirms unique role vs other CCLscorrelates with disease outcome and fibrotic biomarkers Minor expression in healthy tissuesignificantly elevated in liver, skin, lung fibrotic tissue wide therapeutic marginPositive feedback loop potentiates tissue damageresponsible for initiation and perpetuation of fibrosis     

       CCR3  Immune cells recruitment  Fibroblasts activation & proliferation      CCL24  CM-101  Fibrosis  Inflammation    CM-101: A First-in-Class mAb Blocking CCL24  Dual Mechanism of Action Interfering with the Core Fibrotic Pathways    CM-101 attenuates inflammation and fibrosis by inhibiting fibroblasts activation and immune cells recruitment  CM-101 Inhibits Primary Hepatic Fibroblasts Activation  CM-101 Reduces In-vivo Monocyte Recruitment 

         Strong Pre-clinical Evidence of CM-101 via CCL24 Inhibition  Significant Attenuation of Fibrosis & Inflammation Across a Wide Range of Models    Primary sclerosing cholangitisANIT induced cholestasis-chronic and acute (mice)Bile duct ligation (rat)MDR2 knock-out (mice)Systemic sclerosisBleomycin-induced skin fibrosis (mice)Bleomycin induced lung fibrosis (mice)Liver FibrosisTAA induced liver fibrosis (rat and mice)NASHSTAM (mice)MCD diet induced NASH (mice)AtherosclerosisApoE knock out model (mice)  Proof of Concept\Animal Models  Mechanism of Action  Ex-Vivo (Patient Samples)Primary sclerosing cholangitisBiomarkers correlationOverexpression of CCL24 and CCR3Systemic SclerosisFibrotic biomarkers correlationDisease deterioration correlationOverexpression of CCL24 and CCR3 NASHDisease severity correlationOverexpression of CCL24 and CCR3In-Vivo (Knockout Animal Models)Systemic SclerosisCCL24 knock out vs. WT in Bleomycin induced skin fibrosis model (mice)NASHCCL24 knock out vs. WT in MCD induced NASH (mice)  CCL24 Target Validation  Short-term GLP in rodentsLong-term GLP in Non-human primatesEx-vivo safety: ADCC, CDC, cytokine secretionTissue cross reactivity  Toxicology    CM-101 effects on fibroblasts activationDermal, Hepatic and Lung fibroblast activationDermal and liver fibroblast transition to myofibroblastsHepatic fibroblast motilityCM-101 effects on immune cells migration and recruitmentDermal fibroblast migrationMonocyte polarizationMonocytes recruitment 

   Double-Blind, Randomized Escalating Dose (N=32)  CM-101 0.75 mg/kg IV or placebo (n=8)  CM-101 2.5 mg/kg IV or placebo (n=8)  CM-101 5 mg/kg IV or placebo (n=8)  CM-101 10 mg/kg IV or placebo (n=8)    Double-Blind, Randomized Single Dose (N=8)  CM-101 5 mg/kg SC or placebo (n=8)  IV Phase I  End of 42 days follow-up period  SC Phase I    End of 42 days follow-up period  Screening period (up to 28 days)  Follow-up period (6 weeks)  n=40 healthy volunteers     Phase Ia Results  CM-101 was safe and well tolerated at all tested doses up to 10 mg/kg and for both formulations All drug related AEs were classified as mild with no SAEs reportedAverage half-life of 19-21 days (for IV and SC), supports long interval administration once every 2-4 weeksDose-dependent target engagement measured by serum CCL24 levelsComparable target engagement & PK profiles for the SC and IV formulations  IV - Intravenous; SC - Subcutaneous   Single Ascending Dose Study Shows CM-101 to be Safe and Well Tolerated in Healthy Volunteers     

       Wk 15End of treatment  Wk 18End of study  Double-Blind, Randomized Escalating Dose (N=16)  CM-101 2.5 mg/kg IV or placebo (n=8)  CM-101 5 mg/kg SC or placebo (n=8)  Phase Ib  Day 0Randomization    Study population: NAFLD patients with normal liver functionMultiple CM-101 administrations were safe and well tolerated using both IV and SC formulationsMost frequently reported AEs were mild with no drug-related SAEs reportedFavorable t1/2, supports long dosing interval (Q2W - Q4W)  Phase Ib Results  Multiple Administration Study Showed CM-101 to be Safe & Well Tolerated in NAFLD Patients   IV - Intravenous; SC – Subcutaneous; Wk - week  Study Design   Tested doses - 2.5 mg/kg IV infusion and 5 mg/kg SC injection 5 repeated administrations per patient; Q3WPrimary endpoint - safety and tolerability 

         Phase Ib: Confirms CM-101 Anti-Fibrotic Mechanism in Humans  Demonstrated Biomarker Improvement with Dose-Dependent PK-Target Engagement  ProC4-Procollagen 4TIMP1- metallopeptidase inhibitor 1EOT-End of Treatment  PK-Target Engagement   PK-PD 2.5mg/kg IV  PK-PD 5mg/kg SC  Liver Stiffness Relative change from baseline (%)  Nordic Biosciences , Denmark   Fibrotic Biomarkers Improved*  FibroScan™  ProC4  *Concordant results across 6 relevant fibrotic markers  TIMP1  ElastographyDecreased  Relative change from baseline (%)  EOT  EOT 

 CM-101 for the Treatment of Primary Sclerosing Cholangitis 

   Source: Johns Hopkins Medicine   Primary Sclerosing Cholangitis (PSC)   PSC is a rare, chronic liver disease characterized by progressive course of cholestasis with inflammation and fibrosis of the intrahepatic and extrahepatic bile ducts leading to end-stage liver disease and cirrhosisDiagnosis is most often between the age of 30 and 40 years; Predominantly affect men (2:1 male:female ratio)No FDA approved drug; Liver transplant is the only therapy with curative potentialMedian Survival of 10-12 years with no intervention~77K patients in 7 major markets  Lazaridis et al. Primary Sclerosing Cholangitis., N Engl J Med. 2016 James H et al.Primary Sclerosing Cholangitis, Part 1: Epidemiology, Etiopathogenesis, Clinical Features, and Treatment Gastroenterology & Hepatology 20187 Major Markets – USA, 5EU (UK, Germany, France, Italy, Spain), Japan   Potentiating High Morbidity and Mortality 

     CCL24 serum level in PSC patients    Healthy Liver  Collaboration with RFH, UK      PSC Liver  CCL24 STAINING  CCL24 expression is significantly and selectively elevated in PSC livers  CCL24 level in healthy vs PSC patients' livers tissues   CCL24 correlates with ELF in PSC patients with elevated ALP  CCL24 Plays a Key Role in PSC  Clinical Relevance of CCL24 in PSC Pathophysiology is Supported by Patient Samples  ELF – Enhanced Liver Fibrosis; ALP – Alkaline Phosphatase  CCL24 overexpressed in bile epithelial cells  Enhanced Liver Fibrosis (ELF) test reflects fibrosis and predicts clinical outcomes in PSC1  1. M. Vesterhus et al. Hepatology, 62 (1) (2015), pp. 188-197  CM-101 MoA guided the selection of ELF and ALP as Primary endpoints in Phase II 

 % Fibrosis (sirius red staining)  82% reduction      Col1A1Col3A1TIMP1ACTA2TGF-β  ALTASTALP    Liver enzymes  Pro-fibrotic genes    CM-101 Reduces Liver Fibrosis by 82%  Segal-Salto et al, JHEP reports 2020TAA- Thioacetamide  Reduced Liver Collagen in TAA Liver Fibrosis Rat Model Using Therapeutic Design  HEALTHY   TAA  SIRIUS RED (COLLAGEN)  TAA+ CM-101   

   CM-101 Ameliorates Liver Injury and Fibrosis in PSC   Cholestasis, Inflammation and Fibrosis are Reduced in the MDR2 Knockout Model in Mice    Macrophages (IBA1)  Mdr2 -/- + CM-101    Cholangiocytes (panck)    Sirius Red  Mdr2 -/-  Mdr2 -/-  Reduced Macrophages Number  Mdr2 -/- + CM-101  Mdr2 -/-  Mdr2 -/- + CM-101  CM-101 interferes with the core pathways that drive PSC  Decreased Bile Epithelial Cell Proliferation  Attenuated Liver Collagen Deposition   

       IV Administrations of CM-101 vs. Placebo; Q3W  Week 12Last Dose  CM-101 (10mg/kg)  Placebo  Day 0Randomization    n=30  n=30    n=15  Primary endpoints: Serum alkaline phosphatase Change from baseline to W15 ELF score Change from baseline to W15 Secondary endpoints: Fibrotic biomarkers and liver enzymes (e.g. AST, ALT, Pro-C3, Pro-C5) Change from baseline to W15 PK, Anti Drug AntibodyPD parameters  Key inclusion/exclusion criteriaAdults with large duct PSC of more than 24 weeks duration, diagnosed via MRCP/ERCPALP > 1.5 ULNStable IBD is allowed Stable Ursodeoxycholic Acid (UDCA) treatment is allowed   Week 15End of Treatment  Clinicaltrials.gov: NCT04595825  Phase II PSC Study Enrolling PatientsOrphan Drug Designation Granted by FDA and EMA  Trial Design  Topline data expected in 2H2022  IV - Intravenous 

 CM-101 for the Treatment of Systemic Sclerosis 

     Systemic Sclerosis (SSc)   Rare autoimmune rheumatic disease characterized by inflammation and fibrosis of the internal organs as well as vasculopathyAge of diagnosis 30-50 years, Predominantly affect women (3:1 female:male ratio)There is no approved disease modifying drug; Treatments focus on managing disease symptoms (Nintedanib, Tocilizumab)Median Survival of 10 years - the highest mortality rate among the systemic rheumatic diseasesPulmonary involvement is the leading cause of death~170K patients in 7 major markets  Global data; Bergamasco et al., Clin Epidemiol. 2019; 11: 257–2737 Major Markets – USA, 5EU (UK, Germany, France, Italy, Spain), Japan   Most Lethal Among Systemic Rheumatic Diseases  Source: 

       CCL24: A Critical Node Potentiating Systemic Sclerosis (SSc)  Clinical Relevance of CCL24 in SSc Pathophysiology is Supported by Patient Samples  dSSc – diffuse systemic sclerosisMor A et al., Annals of Rheumatic Diseases, 2019***p ≤0.001     CCL24 overexpressed in skin and serum samples of dSSc Patients compared to healthyCCL24 correlates with disease progression and fibrotic biomarkers  ***  SSc Skin  Collaboration with University of Florence  Healthy Skin  CCL24 serum level correlates with worsening of lung functions  CCL24 is highly elevated in dSSc population  Patient samples support the targeted patient population and clinical trial endpoints 

     CCL24 Blockade is Singularly Sufficient to Attenuate Fibrosis  Knocking Out the CCL24 Gene Attenuates Inflammation and Fibrosis in SSc Bleomycin Experimental Model  Mor A et al., Annals of Rheumatic Diseases, 2019BLM – Bleomycin; WT - Wild type; KO – Knockout, BAL- Bronchoalveolar lavage, PBS- Phosphate-buffered saline *p ≤0.05   WT-PBS  CCL24 KO-PBS  WT-BLM  CCL24 KO-BLM  Fold increase expression   α SMA expression in skin lesions  Dermal thickness  Dermal thickness compared to average control groups  *  *  # cells infiltrating to BAL  Immune cell lung infiltration   *  WT-BLM  CCL24KO-BLM   

     CM-101 Profoundly Reduces Skin and Lung Fibrosis in SSc  Experimental Models Relevant to Systemic Sclerosis Using Prevention and Therapeutic Designs  Mor et al, Annals of Rheumatoid Diseases, 2019**p ≤0.01; *p ≤0.05. BLM - bleomycin; IT - Intratracheal; SC – SubcutaneousIgG - Immunoglobulin G   Attenuates skin and lung fibrosis levels in bleomycin induced models using treatment modeDemonstrates a dose dependent attenuation of fibrosisReduces lung collagen and inflammation as compared to approved drugs for lung fibrosis  Collagen concentration (µg/gr tissue)  Vehicle  BLM  BLM+CM-101 0.5mg/kg  BLM+CM-101 1mg/kg  BLM+CM-101 2.5mg/kg  BLM+lgG  *  *  **  Bleomycin (SC) induced dermal fibrosis    Bleomycin (IT) induced lung fibrosis 

   CM-101 Clinical Development Plan and Key Catalysts   SC – Subcutaneous, MoA- Mechanism of Action *NCT04595825  Advancing in Parallel Three Phase II Clinical Programs          Status  2021  2022  2023  Primary Sclerosing Cholangitis   EnrollingTop line data expected in 2H2022        Systemic Sclerosis  Initiation expected in 1Q2022        Liver FibrosisProof of MoA using SC formulation  EnrollingTop line data expected in 1H2022        Phase II: 15wk treatment*Randomized placebo-controlled;Europe and Israel study sites  Phase II 24-48wkRandomized placebo-controlled;US & Europe study sites  Phase IIa: 16 wk treatmentRandomized placebo-controlled;Israel study sites   

     Investment Summary  Pioneering Innovative Treatment for Fibrosis-Related Diseases with High Unmet Need  IV – Intravenous; SC - Subcutaneous   Chemomab Clinical stage company advancing PhII trials in multiple fibrotic indications with high unmet need Substantial near term value inflection pointsStrong leadership with proven track record  PK & Mode of AdministrationOptimal PK for both SC and IV formulationsComparable exposure levels and target engagement using both formulations  EfficacyFirst anti-fibrotic evidence in patientsSignificant anti-fibrotic effects across multiple in vivo, ex vivo and in vitro models  CM-101First-in-class mAb blocking CCL24Novel and differentiated dual anti-fibrotic and anti-inflammatory MoA SC and IV formulations available; well established manufacturing processStrong IP protection  SafetyFavorable safety and tolerability that support chronic treatment based on toxicology, Phase Ia and Phase Ib clinical trials   

 Presentation name  Thank You 

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Document and Entity Information	Sep. 02, 2021
Entity Listings [Line Items]
Document Type	8-K
Amendment Flag	false
Document Period End Date	Sep. 02, 2021
Entity Registrant Name	Chemomab Therapeutics Ltd.
Entity Incorporation, State or Country Code	L3
Entity File Number	001-38807
Entity Tax Identification Number	00-0000000
Entity Address, Address Line One	Kiryat Atidim, Building 7
Entity Address, City or Town	Tel Aviv
Entity Address, Country	IL
Entity Address, Postal Zip Code	6158002
City Area Code	972
Local Phone Number	77-331-0156
Written Communications	false
Soliciting Material	false
Pre-commencement Tender Offer	false
Pre-commencement Issuer Tender Offer	false
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Central Index Key	0001534248
American Depositary Shares, each representing twenty (20) ordinary shares, no par value per share [Member]
Entity Listings [Line Items]
Title of 12(b) Security	American Depositary Shares, each representing twenty (20) ordinary shares, no par value per share
Trading Symbol	CMMB
Security Exchange Name	NASDAQ
Ordinary shares, no par value per share [Member]
Entity Listings [Line Items]
Title of 12(b) Security	Ordinary shares, no par value per share
Trading Symbol	N/A
Security Exchange Name	NASDAQ