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Income Taxes - Schedule of Reconciliation of Federal Statutory Income Tax Rate to Effective Income Tax Rate (Detail)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Income Taxes [Abstract]    
Federal statutory income tax rate 21.00% 21.00%
State income taxes, net of federal benefit (2.50%) 0.60%
Research and development tax credits 1.70% 1.40%
Other (5.30%) (0.40%)
Change in valuation allowance (14.90%) (22.60%)