EX-32.1 9 a2228030zex-32_1.htm EX-32.1
QuickLinks -- Click here to rapidly navigate through this document


EXHIBIT 32.1

CERTIFICATION

        Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, Frederic F. Brace, Interim President and Chief Executive Officer of Midstates Petroleum Company, Inc. (the "Company"), certifies that, to his knowledge:

    1.
    the Annual Report on Form 10-K of the Company for the period ending December 31, 2015, as filed with the Securities and Exchange Commission on the date hereof (the "Report"), fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and

    2.
    the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: March 30, 2016   /s/ FREDERIC F. BRACE
 Frederic F. Brace
 Interim President and Chief Executive Officer
(Principal Executive Officer)



QuickLinks

CERTIFICATION