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Stock-based Compensation - Schedule of Assumptions Used to Determine Fair Value of Option Grants (Detail)
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Risk-free interest rate, Minimum 2.70% 1.96%
Risk-free interest rate, Maximum 2.84% 2.49%
Expected volatility, Minimum 91.28% 83.32%
Expected volatility, Maximum 91.48% 123.01%
Weighted average expected volatility 91.38% 84.23%
Expected lives (in years) 10 years  
Expected dividend yield 0.00% 0.00%
Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected lives (in years)   5 years 2 months 12 days
Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected lives (in years)   10 years