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Stock-based Compensation - Schedule of Assumptions Used to Determine Fair Value of Option Grants (Detail)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Risk-free interest rate, Minimum 1.18% 1.47%
Risk-free interest rate, Maximum 2.02% 2.43%
Expected volatility, Minimum 79.42% 84.93%
Expected volatility, Maximum 116.88% 116.81%
Weighted average expected volatility 89.12% 89.26%
Expected dividend yield 0.00% 0.00%
Minimum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected lives (in years) 5 years 2 months 12 days 5 years 2 months 12 days
Maximum [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected lives (in years) 10 years 10 years