Capital Raises (Details) - USD ($) $ / shares in Units, $ in Thousands									3 Months Ended		12 Months Ended
	Sep. 13, 2021	Feb. 16, 2021	Feb. 12, 2021	Feb. 11, 2021	Jan. 24, 2021	Nov. 25, 2020	Jun. 19, 2020	Mar. 03, 2020	Mar. 31, 2021	Dec. 31, 2020	Dec. 31, 2021	Dec. 31, 2020
Capital Raises (Textual)
Aggregate offering amount							$ 150,000
Common stock issued in direct offering (in shares)										5,000,000
Proceeds from warrant exercises		$ 18,500	$ 27,800		$ 27,800	$ 9,200
Number of common shares sold under offering (in shares)		15,800,000		3,000,000
Exercisable, weighted average exercise price (in usd per share)										$ 70.84	$ 15.19	$ 70.84
Preferred stock, shares authorized (in shares)										5,000,000	5,000,000	5,000,000
Net proceeds from issuance of preferred stock and warrants	$ 50,600										$ 50,585	$ 0
Series 7 Preferred Stock
Capital Raises (Textual)
Preferred stock, shares issued (in shares)											49,250
Preferred stock, shares outstanding (in shares)											49,250
Mezzanine equity, convertible preferred shares, par value per share (in usd per share)	$ 0.001
Mezzanine equity, convertible preferred shares, stated value per share (in usd per share)	1,000
Mezzanine equity, convertible preferred shares, conversion price (in usd per share)	1.25
Common Stock
Capital Raises (Textual)
Mezzanine equity, convertible preferred shares, conversion price (in usd per share)	1.25
Purchase Warrants
Capital Raises (Textual)
Exercisable warrants per common share (in shares)		1	1
Registered Direct Offering
Capital Raises (Textual)
Common stock issued in direct offering (in shares)		3,000,000	7,000,000		5,800,000	5,000,000			15,800,000
Subscription price (in usd per share)	$ 920
Original issuance discount percentage	8.00%
Aggregate subscription value	$ 54,100
Registered Direct Offering | Series 7 Preferred Stock
Capital Raises (Textual)
Number of common shares sold under offering (in shares)	58,750
Registered Direct Offering | Common Stock
Capital Raises (Textual)
Number of common shares sold under offering (in shares)	47,000,000
Registered Direct Offering | Purchase Warrants
Capital Raises (Textual)
Exercisable warrants per common share (in shares)					1	1
Maxim Warrant
Capital Raises (Textual)
Aggregate offering amount							$ 150,000	$ 50,000
Commission percentage rate							3.25%	4.00%
Warrant
Capital Raises (Textual)
Common stock issued in direct offering (in shares)										3,000,000
Warrants to purchase shares of common stock after adjustment		9,950,250	15,000,000		19,354,838
Exercise price of warrants (in usd per share)										$ 0.001	$ 0.001	$ 0.001
Exercisable, weighted average exercise price (in usd per share)										6.70	$ 1.97	$ 6.70
Percent of warrants forfeited upon redemption	75.00%
Warrant | Purchase Warrants
Capital Raises (Textual)
Exercise price of warrants (in usd per share)		$ 2.01	$ 2.00		$ 1.55	$ 1.25
Offering price (in usd per share)		$ 2.01	$ 2.00		$ 1.55	$ 1.25
Warrant | Registered Direct Offering
Capital Raises (Textual)
Common stock issued in direct offering (in shares)		3,000,000	7,000,000		5,800,000	5,000,000
Warrants to purchase shares of common stock after adjustment					19,354,838	8,000,000
Number of common shares sold under offering (in shares)	47,000,000
Warrants classified as equity, discount	$ 4,700
Warrant | Registered Direct Offering | Purchase Warrants
Capital Raises (Textual)
Exercise price of warrants (in usd per share)					$ 1.55	$ 1.25
Offering price (in usd per share)					$ 1.55	$ 1.25
January 2021 Pre-Funded Warrants
Capital Raises (Textual)
Warrants to purchase shares of common stock after adjustment					13,554,838
Exercise price of warrants (in usd per share)					$ 0.001
Offering price (in usd per share)					$ 1.549
Exercisable warrants per common share (in shares)					1
Warrants exercisable period					5 years
February 2021 Pre-Funded Warrants
Capital Raises (Textual)
Warrants to purchase shares of common stock after adjustment			8,000,000
Exercise price of warrants (in usd per share)			$ 0.001
Offering price (in usd per share)			$ 1.999
Exercisable warrants per common share (in shares)			1
Warrants exercisable period			5 years
Second February 2021 Pre-Funded Warrants
Capital Raises (Textual)
Warrants to purchase shares of common stock after adjustment		6,950,250
Exercise price of warrants (in usd per share)		$ 0.001
Offering price (in usd per share)		$ 2.009
Exercisable warrants per common share (in shares)		1
Warrants exercisable period		5 years
2020 Pre-Funded Warrant
Capital Raises (Textual)
Warrants to purchase shares of common stock after adjustment						3,000,000
Offering price (in usd per share)						$ 1.249
Exercisable, weighted average exercise price (in usd per share)						$ 0.001
ATM
Capital Raises (Textual)
Commission percentage rate												4.00%
Number of common shares sold under offering (in shares)												33,416,830
Share price (in usd per share)										$ 1.45		$ 1.45
Net proceeds from ATM public offering												$ 46,100