License, collaboration and commercial agreements - Sanofi (Details) $ in Thousands		1 Months Ended	12 Months Ended
	Jul. 25, 2019 USD ($)	Aug. 31, 2019 USD ($)	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($) Milestone	Dec. 31, 2019 USD ($)
License and collaboration agreements
Total revenue			$ 2,053	$ 88,516	$ 17,456
License and collaboration revenue
License and collaboration agreements
Total revenue				$ 2,912	5,117
License and Collaboration Agreement | Sanofi
License and collaboration agreements
Proceeds received		$ 5,000
Maximum aggregate payments entitled to receive if all milestones successfully achieved	$ 42,000
Number of additional milestones achieved | Milestone				2
License revenue				$ 2,500
Percentage of future milestone payments and royalties entitled			50.00%
License and Collaboration Agreement | Sanofi | License and collaboration revenue
License and collaboration agreements
Total revenue					$ 5,000