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Fair Value Measurements - Recurring Fair Value Measurements (Details) - USD ($)
$ in Thousands
Mar. 31, 2022
Dec. 31, 2021
Assets    
Marketable securities $ 447,046 $ 452,875
Fair Value, Measurements, Recurring    
Assets    
Total assets 1,602,658 1,666,418
Fair Value, Measurements, Recurring | Money market funds    
Assets    
Money market funds 1,155,612 1,213,543
Fair Value, Measurements, Recurring | U.S. government securities    
Assets    
Marketable securities 412,453 418,284
Fair Value, Measurements, Recurring | Commercial paper    
Assets    
Marketable securities 15,972 13,878
Fair Value, Measurements, Recurring | Asset-backed securities    
Assets    
Marketable securities 0 2,002
Fair Value, Measurements, Recurring | Corporate debt securities    
Assets    
Marketable securities 18,621 18,711
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 1    
Assets    
Total assets 1,568,065 1,631,827
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 1 | Money market funds    
Assets    
Money market funds 1,155,612 1,213,543
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 1 | U.S. government securities    
Assets    
Marketable securities 412,453 418,284
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 1 | Commercial paper    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 1 | Asset-backed securities    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 1 | Corporate debt securities    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2    
Assets    
Total assets 34,593 34,591
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 | Money market funds    
Assets    
Money market funds 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 | U.S. government securities    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 | Commercial paper    
Assets    
Marketable securities 15,972 13,878
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 | Asset-backed securities    
Assets    
Marketable securities 0 2,002
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 2 | Corporate debt securities    
Assets    
Marketable securities 18,621 18,711
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3    
Assets    
Total assets 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3 | Money market funds    
Assets    
Money market funds 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3 | U.S. government securities    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3 | Commercial paper    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3 | Asset-backed securities    
Assets    
Marketable securities 0 0
Fair Value, Measurements, Recurring | Fair Value, Inputs, Level 3 | Corporate debt securities    
Assets    
Marketable securities $ 0 $ 0