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Marketable Securities (Tables)
3 Months Ended
Mar. 31, 2022
Investments [Abstract]  
Marketable Securities
The amortized cost, unrealized gain (loss), and estimated fair value of the Company's investments in securities available for sale consisted of the following:
March 31, 2022
Amortized CostUnrealized GainUnrealized LossEstimated Fair Value
Marketable securities
U.S. government securities$420,277 $— $(7,824)$412,453 
Commercial paper15,972— 15,972
Asset-backed securities— 
Corporate debt securities18,793(172)18,621
Total marketable securities$455,042 $— $(7,996)$447,046 

December 31, 2021
Amortized CostUnrealized GainUnrealized LossEstimated Fair Value
Marketable securities
U.S. government securities$420,392 $— $(2,107)$418,285 
Commercial paper13,878— 13,878
Asset-backed securities2,003(1)2,002
Corporate debt securities18,7313(24)18,710
Total marketable securities$455,004 $$(2,132)$452,875 
Schedule of Available-for-sale Securities Reconciliation
The following table summarizes the stated maturities of the Company’s marketable securities:
March 31, 2022December 31, 2021
Amortized CostEstimated Fair ValueAmortized CostEstimated Fair Value
Due within one year$167,575 $165,767 $64,914 $64,879 
Due after one year through two years287,467281,279390,090387,996
Total$455,042 $447,046 $455,004 $452,875