XML 25 R4.htm IDEA: XBRL DOCUMENT v3.22.4
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
REVENUES:      
Total revenues $ 1,111,795 $ 1,173,751 $ 1,038,756
EXPENSES:      
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 218,108 197,387 178,316
Research and development 393,842 406,526 394,588
Selling, general and administrative 605,747 560,977 538,827
Amortization of acquired intangible assets 36,363 38,148 39,452
Total expenses 1,254,060 1,203,038 1,151,183
OPERATING LOSS (142,265) (29,287) (112,427)
OTHER (EXPENSE) INCOME, NET:      
Interest income 7,629 2,408 6,960
Interest expense (13,040) (11,219) (8,659)
Change in the fair value of contingent consideration (21,750) (1,427) 3,945
Other income, net 2,122 219 13,644
Total other (expense) income, net (25,039) (10,019) 15,890
LOSS BEFORE INCOME TAXES (167,304) (39,306) (96,537)
INCOME TAX (BENEFIT) PROVISION (9,037) 8,863 14,324
NET LOSS $ (158,267) $ (48,169) $ (110,861)
LOSS PER ORDINARY SHARE:      
Basic $ (0.97) $ (0.30) $ (0.70)
Diluted $ (0.97) $ (0.30) $ (0.70)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:      
Basic 163,541 160,942 158,803
Diluted 163,541 160,942 158,803
COMPREHENSIVE LOSS:      
Net loss $ (158,267) $ (48,169) $ (110,861)
Holding loss, net of a tax (benefit) provision of $(973), $(706) and $130, respectively (7,166) (2,374) 467
COMPREHENSIVE LOSS (165,433) (50,543) (110,394)
Product sales, net      
REVENUES:      
Total revenues 777,552 627,424 551,760
Manufacturing and royalty revenues      
REVENUES:      
Total revenues 331,983 541,807 484,000
License revenue      
REVENUES:      
Total revenues 2,000 3,500 1,050
Research and development revenue      
REVENUES:      
Total revenues $ 260 $ 1,020 $ 1,946