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Collaborative Arrangements (Details) (USD $)
In Thousands, unless otherwise specified
12 Months Ended
Dec. 31, 2013
Dec. 31, 2012
Dec. 31, 2011
Research and development, net $ 52,310 $ 19,659 $ 14,360
Collaborative Arrangement [Member]
     
Research and development, net $ 3,600 $ 3,200 $ 700