Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Product revenue allowances	$ 29,005	$ 26,624
Accrued clinical	5,755	14,036
Amounts due to collaboration partners	0	22,654
Accrued payroll and related	11,481	15,863
Lease liability	$ 4,744	$ 4,802
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Total accrued expenses	Total accrued expenses
Royalties	$ 3,804	$ 3,472
Professional fees	1,734	1,899
Accrued commercial manufacturing	4,310	3,843
Accrued restructuring	2,751	0
Accrued other	7,413	11,263
Total accrued expenses	$ 70,997	$ 104,456