Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenues:
Total revenues	$ 292,602	$ 213,578	$ 295,307
Cost of goods sold:
Product	48,754	117,352	148,866
Amortization of intangibles	36,042	36,042	31,515
Impairment of intangible asset	0	0	115,527
Total cost of goods sold	84,796	153,394	295,908
Operating expenses:
Research and development	129,114	147,852	218,485
Selling, general and administrative	138,699	174,161	153,947
License expense	3,175	3,489	3,409
Restructuring	15,933	0	0
Total operating expenses	286,921	325,502	375,841
Operating loss	(79,115)	(265,318)	(376,442)
Other income (expense):
Interest income (expense)	(15,687)	(19,936)	(8,871)
Other income (expense)	3,146	2,414	1,856
Loss on extinguishment of debt	(906)	0	0
Net loss before income taxes	(92,562)	(282,840)	(383,457)
Benefit from income taxes	0	0	0
Net loss	$ (92,562)	$ (282,840)	$ (383,457)
Net loss per share - basic (in dollars per share)	$ (0.51)	$ (1.70)	$ (2.77)
Net loss per share - diluted (in dollars per share)	$ (0.51)	$ (1.70)	$ (2.77)
Weighted-average number of common shares - basic (in shares)	182,782,680	165,949,695	138,463,152
Weighted-average number of common shares - diluted (in shares)	182,782,680	165,949,695	138,463,152
Comprehensive loss:
Net loss	$ (92,562)	$ (282,840)	$ (383,457)
Other comprehensive (loss) gain - unrealized (loss) gain on securities	0	(7)	13
Total comprehensive loss	(92,562)	(282,847)	(383,444)
Product revenue, net
Revenues:
Total revenues	177,067	142,216	128,901
License, collaboration and other revenue
Revenues:
Total revenues	$ 115,535	$ 71,362	$ 166,406