Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities:
Net loss	$ (85,010)	$ (212,162)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,246	1,485
Amortization of intangibles	27,032	27,032
Amortization of premium/discount on investments	0	(15)
Non-cash interest expense related to sale of future royalties	6,352	6,779
Non-cash royalty revenue related to sale of future royalties	(1,195)	(425)
Non-cash collaboration revenue	(9,550)	0
Non-cash R&D expense	3,941	0
Non-cash interest expense	1,467	852
Non-cash operating lease expense	(1,818)	(1,415)
Loss on extinguishment of debt	406	0
Fair value step-up of inventory sold or written off	0	21,575
Write-down of inventory	10,002	7,126
Change in excess inventory purchase commitments	12,422	15,376
Stock-based compensation	14,808	18,099
Change in fair value of derivative liability	(1,060)	(490)
Changes in operating assets and liabilities:
Accounts receivable	27,781	(22,837)
Inventory	1,405	(35,282)
Prepaid expenses and other current assets	9,131	(25,020)
Other long-term assets	14,817	4,728
Accounts payable	(17,420)	(14,933)
Accrued expense	(22,364)	15,099
Operating lease liabilities	1,771	1,173
Deferred revenue	2,181	3,098
Other non-current liabilities	(14,820)	0
Net cash used in operating activities	(18,475)	(190,157)
Investing activities:
Purchase of equipment	(114)	(59)
Proceeds from the maturities of available for sale securities	0	40,000
Net cash (used in) provided by investing activities	(114)	39,941
Financing activities:
Proceeds from sale of future royalties, net	0	44,783
Proceeds from refund liabilities to customers	40,000	0
Proceeds from the issuance of common stock, net of issuance costs	7,122	82,799
Proceeds from the sale of stock under employee stock purchase plan	410	746
Proceeds from the exercise of stock options	67	0
Payments on debt	(33,000)	0
Net cash provided by financing activities	14,599	128,328
(Decrease) in cash, cash equivalents, and restricted cash	(3,990)	(21,888)
Cash, cash equivalents, and restricted cash at beginning of the period	151,839	231,132
Cash, cash equivalents, and restricted cash at end of the period	147,849	209,244
Non-cash financing activities
Unpaid offering costs	$ 0	$ 57