Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Product revenue allowances	$ 25,222	$ 26,624
Accrued clinical	8,652	14,036
Amounts due to collaboration partners	19,550	22,654
Accrued payroll and related	9,140	15,863
Lease liability	$ 4,260	$ 4,802
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Total accrued expenses	Total accrued expenses
Royalties	$ 2,916	$ 3,472
Professional fees	1,725	1,899
Accrued commercial manufacturing	3,167	3,843
Accrued restructuring	4,238	0
Accrued other	8,494	11,263
Total accrued expenses	$ 87,364	$ 104,456