Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues:
Total revenues	$ 48,964	$ 48,756	$ 237,422	$ 153,973
Cost of goods sold:
Product	28,936	6,933	60,859	76,012
Amortization of intangibles	9,011	9,011	27,032	27,032
Total cost of goods sold	37,947	15,944	87,891	103,044
Operating expenses:
Research and development	27,350	40,471	97,210	118,296
Selling, general and administrative	30,918	46,357	108,052	129,336
License expense	743	870	2,323	2,460
Restructuring	180	0	14,711	0
Total operating expenses	59,191	87,698	222,296	250,092
Operating loss	(48,174)	(54,886)	(72,765)	(199,163)
Other income (expense):
Interest expense	(3,952)	(5,085)	(14,051)	(14,853)
Other income	1,167	427	2,712	1,854
Loss on extinguishment of debt	(906)	0	(906)	0
Net loss, basic	(51,865)	(59,544)	(85,010)	(212,162)
Net loss, diluted	$ (51,865)	$ (59,544)	$ (85,010)	$ (212,162)
Net loss per share - basic (in dollars per share)	$ (0.28)	$ (0.34)	$ (0.47)	$ (1.30)
Net loss per share - diluted (in dollars per share)	$ (0.28)	$ (0.34)	$ (0.47)	$ (1.30)
Weighted-average number of common shares - basic (in shares)	183,882,446	173,782,151	182,375,443	163,050,769
Weighted-average number of common shares - diluted (in shares)	183,882,446	173,782,151	182,375,443	163,050,769
Comprehensive loss:
Net income (loss)	$ (51,865)	$ (59,544)	$ (85,010)	$ (212,162)
Other comprehensive loss - unrealized loss on debt securities	0	0	0	(7)
Total comprehensive loss	(51,865)	(59,544)	(85,010)	(212,169)
Product revenue, net
Revenues:
Total revenues	42,239	36,753	127,390	100,120
License, collaboration and other revenue
Revenues:
Total revenues	$ 6,725	$ 12,003	$ 110,032	$ 53,853