License, Collaboration and Other Significant Agreements - Revenues Recognized From License, Collaboration and Other Significant Agreements (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
License, Collaboration and Other Revenue:
Total revenues	$ 48,964	$ 48,756	$ 237,422	$ 153,973
Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues			2,400
License, collaboration and other revenue
License, Collaboration and Other Revenue:
Total revenues	6,725	12,003	110,032	53,853
License, collaboration and other revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	5,487	2,555	13,885	7,167
License, collaboration and other revenue | Otsuka Pharmaceutical Company. Ltd. | Otsuka U.S. Agreement
License, Collaboration and Other Revenue:
Total revenues	0	6,144	86,773	28,988
License, collaboration and other revenue | Otsuka Pharmaceutical Company. Ltd. | Otsuka International Agreement
License, Collaboration and Other Revenue:
Total revenues	0	1,860	5,503	13,532
License, collaboration and other revenue | Total Proportional Performance Revenue
License, Collaboration and Other Revenue:
Total revenues	5,487	10,559	106,161	49,687
License, collaboration and other revenue | JT and Torii
License, Collaboration and Other Revenue:
Total revenues	1,238	1,444	3,871	4,093
License, collaboration and other revenue | MTPC Other Revenue | Mitsubishi Tanabe Pharma Corporation
License, Collaboration and Other Revenue:
Total revenues	$ 0	$ 0	$ 0	$ 73