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Accrued Expenses
 9 Months Ended
Sep. 30, 2022
Payables and Accruals [Abstract]  
Accrued Expenses Accrued Expenses
Accrued expenses as of September 30, 2022 and December 31, 2021 are as follows:
 
 September 30, 2022December 31, 2021
 (in thousands)
Product revenue allowances$25,222 $26,624 
Accrued clinical8,652 14,036 
Amounts due to collaboration partners19,550 22,654 
Accrued payroll and related9,140 15,863 
Lease liability4,260 4,802 
Royalties2,916 3,472 
Professional fees1,725 1,899 
Accrued commercial manufacturing3,167 3,843 
Accrued restructuring4,238 — 
Accrued other8,494 11,263 
Total accrued expenses$87,364 $104,456