Condensed Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Total revenues	$ 126,759	$ 52,913	$ 188,458	$ 105,217
Cost of goods sold:
Product	9,589	43,484	31,923	69,079
Amortization of intangibles	9,011	9,011	18,021	18,021
Total cost of goods sold	18,600	52,495	49,944	87,100
Operating expenses:
Research and development	26,027	37,214	69,860	77,825
Selling, general and administrative	32,807	41,651	77,134	82,979
License expense	892	894	1,580	1,590
Restructuring	14,531	0	14,531	0
Total operating expenses	74,257	79,759	163,105	162,394
Operating income (loss)	33,902	(79,341)	(24,591)	(144,277)
Other income (expense):
Interest expense	(5,037)	(4,962)	(10,099)	(9,768)
Other income	411	1,265	1,545	1,427
Net loss, basic	29,276	(83,038)	(33,145)	(152,618)
Net loss, diluted	$ 29,276	$ (83,038)	$ (33,145)	$ (152,618)
Net loss per share - basic (in dollars per share)	$ 0.16	$ (0.51)	$ (0.18)	$ (0.97)
Weighted-average number of common shares - basic (in shares)	183,597,766	161,329,990	181,609,452	157,596,143
Net loss per share - diluted (in dollars per share)	$ 0.15	$ (0.51)	$ (0.18)	$ (0.97)
Weighted-average number of common shares - diluted (in shares)	190,375,317	161,329,990	181,609,452	157,596,143
Comprehensive income (loss):
Net income (loss)	$ 29,276	$ (83,038)	$ (33,145)	$ (152,618)
Other comprehensive loss - unrealized loss on debt securities	0	(3)	0	(7)
Total comprehensive income (loss)	29,276	(83,041)	(33,145)	(152,625)
Product revenue, net
Revenues:
Total revenues	43,703	32,959	85,151	63,367
License, collaboration and other revenue
Revenues:
Total revenues	$ 83,056	$ 19,954	$ 103,307	$ 41,850