Income Taxes - Significant Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Accrued expenses	$ 3,306	$ 3,079
Deferred revenue	9,725	9,091
Sale of Royalty	12,037	0
Stock based compensation	9,194	10,014
Research and development credits	5,034	4,620
Other non-current liabilities	20,424	17,015
Net operating loss carryforward	286,908	262,532
ASC 842 lease liability	9,096	6,776
Fixed assets	799	700
UNICAP	3,190	2,132
Inventory Reserve	10,281	8,260
Derivative Liability	413	542
Other	6,081	2,535
Total deferred tax assets	376,488	327,296
Less valuation allowance	(342,122)	(277,941)
Total deferred tax assets, net of valuation allowance	34,366	49,355
Deferred tax liabilities:
Fixed assets	0	0
Intangible assets	(25,598)	(34,178)
Inventory	0	(8,479)
ASC 842 ROU asset	(8,486)	(6,101)
Other	(282)	(597)
Total deferred tax liabilities	(34,366)	(49,355)
Net deferred tax liability	$ 0	$ 0