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Income Taxes - Effective Income Tax Rate Differs From Statutory Federal Income Tax Rate (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Disclosure [Abstract]      
Federal tax at statutory rate 21.00% 21.00% 21.00%
State and local tax at statutory rate 3.00% 3.00% 5.50%
Research and development tax credits 0.00% 0.10% 2.00%
Change in valuation allowance (22.70%) (21.50%) (22.40%)
Other permanent differences (1.00%) (0.40%) (0.30%)
Reduction in deferred tax assets for change in ownership 0.00% 0.00% (1.60%)
Effect of rate changes 0.30% 0.80% (1.40%)
Provision to Return Adjustment 0.30% (1.50%) 0.00%
Prior Period Adjustment to State NOL DTA 0.00% (1.50%) 0.00%
Other (0.90%) 0.00% (0.50%)
Effective tax rate 0.00% 0.00% 2.30%