Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Payables and Accruals [Abstract]
Product revenue allowances	$ 26,624	$ 38,049
Accrued clinical	14,036	28,986
Collaborative arrangement accrued liability	22,654	17,977
Otsuka PRV contribution	0	10,000
Accrued payroll and related	15,863	14,899
Lease liability	$ 4,802	$ 5,286
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Total accrued expenses	Total accrued expenses
Royalties	$ 3,472	$ 2,998
Professional fees	1,899	3,271
Accrued commercial manufacturing	3,843	514
Accrued other	11,263	8,644
Total accrued expenses	$ 104,456	$ 130,624