License, Collaboration and Other Significant Agreements - Sublicense Agreement with Japan Tobacco, Inc. and its subsidiary, Torii Pharmaceutical Co., Ltd. Narrative (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($) performance_obligation	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues	$ 213,578	$ 295,307	$ 335,001
JT and Torii | Sublicense Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Potential payment for achievement of annual net sales milestones	$ 55,000
License agreement, notice period for termination	6 months
Prior written notice for termination on the breach of agreement period	60 days
Number of performance obligations | performance_obligation	2
Total revenues	$ 5,800	$ 5,700	$ 5,900